Diagnostic markers

Precision oncology involves analysis of individual cancer samples to understand the genes and pathways involved in the development and progression of a cancer. To improve patient care, knowledge of diagnostic, prognostic, predisposing, and drug response markers is essential.

16p vibransone 28-03-2024 2 2   Download

Ebook "Diagnostics in plant breeding" is systematically organizing cutting-edge research reviews on the development and application of molecular tools for the prediction of plant performance. Given its significance for mankind and the available research resources, medical sciences are leading the area of molecular diagnostics, where DNA-based risk assessments for various diseases and biomarkers to determine their onset become increasingly available.

517p lucchinguyen 28-12-2023 4 2   Download

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) and T cell/histiocyte-rich large B-cell lymphoma (THRLBCL) have overlapping histological features that make their diagnosis challenging. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is a recently proposed diagnostic marker for Hodgkin’s lymphoma.

10p vileonardodavinci 23-12-2023 3 2   Download

Histological grade has been demonstrated to be an important factor of breast cancer outcome and is associated with cell differentiation and is currently being evaluated via H&E-stained sections. Molecular biomarkers are essential to improve the accuracy of histological grading.

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This study aims to explore the diagnostic efficiency of quantitative computed tomography (CT) parameters combined with preoperative systemic inflammatory markers in differentiating low-risk thymic epithelial tumors (LTETs) from high-risk thymic epithelial tumors (HTETs).

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Several studies have reported that circulating tumor cells (CTCs) are a promising marker for the diagnosis of thyroid cancer (TC) with recurrence or distant metastasis (DMs). However, some studies emerged with conflicting results.

9p vialfrednobel 23-12-2023 5 4   Download

CircN4BP2L2 was previously identified to be significantly decreased in epithelial ovarian cancer (EOC) and was associated with disease progression. The aim of this study was to evaluate the diagnostic value of plasma circN4BP2L2 using the unifying model of type I and type II EOC.

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The purpose of this study was to compare the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP) and aspartic aminotransferase to alanine aminotransferase ratios (AAR), both alone and in combination, for predicting hepatocellular carcinoma (HCC) onset.

11p vialfrednobel 23-12-2023 3 3   Download

Previous studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical evaluation of different IHC markers, so this study aimed to evaluate characteristics of CUP and recommend a diagnostic strategy from a single center in China.

10p vialfrednobel 23-12-2023 2 2   Download

Part 1 book "Protocols for the diagnosis of pig viral diseases" includes content: Requirements and preparedness for attending a viral disease outbreak in pig farms; collection of samples, their preservation and transportation; methods for quantification of viruses; protocols for isolation of genetic materials from RNA viruses; multiplex pcr for diagnosis of porcine diseases; protocols for isolation of plasmid DNA,... and other contents.

203p muasambanhan02 18-12-2023 4 3   Download

Part 1 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery, the bittersweet promise of glycobiology; biomarkers of Alzheimer's and Parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.

336p oursky07 23-10-2023 1 1   Download

Part 2 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer; biomarkers of HIV; biomarkers of in vitro drug induced mitochondrial dysfunction; immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research; nanoscale techniques for biomarker quantification; immunodiagnostics with a focus on lateral flow point of care devices,... and other contents.

312p oursky07 23-10-2023 7 1   Download

To investigate the expression of carcinoembryonic antigen (CEA), cancer antigen 199 (CA199) and CA125 in serum and ascites of appendiceal pseudomyxoma peritonei (PMP) patients relative to their diagnostic and predictive value.

8p vischultz 20-10-2023 3 1   Download

Glioma is characterized by high morbidity, high mortality, and poor prognosis. Despite tremendous advances in the treatment of glioma, the prognosis of patients with glioma is still unsatisfactory. There is an urgent need to discover novel molecular markers that effectively predict prognosis in patients with glioma.

16p vischultz 20-10-2023 1 1   Download

An early diagnosis of pancreatic cancer (PC) is extremely difficult because of the lack of sensitive liquid biopsy methods and effective biomarkers. We attempted to evaluate whether circulating inflammatory marker could complement CA199 for the detection of early-stage PC.

18p vischultz 20-10-2023 1 1   Download

Liver cancer is the third most deadly malignant tumor in the world with poor prognosis and lacks early diagnostic markers. It is urgent need to explore new biomarkers and prognostic factors. The oxysterol-binding protein-like family proteins (OSBPLs) are essential mediators of lipid transportation and cholesterol balancing which has been reported to participate in cancer progression.

11p vischultz 20-10-2023 3 1   Download

To unravel how the integrity of nuclear and mitochondrial circulating cell-free DNA (cfDNA) contributes to its plasma quantity in colorectal cancer (CRC) patients. Methods CfDNA from plasma samples of 80 CRC patients stratified by tumour stage and 50 healthy individuals were extracted. Total cfDNA concentration was determined and equal template concentrations (ETC) were analyzed by quantitative real-time PCR (qPCR) resulting in small and long fragments of KRAS, Alu and MTCO3.

14p vischultz 20-10-2023 4 1   Download

Most cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic mark‑ ers in cell-free DNA (cfDNA) is a promising tool for the diagnosis of lung cancer at an early stage. The aim of this study was to identify non-invasive diagnostic markers in cell free DNA (cfDNA) for non-small cell lung cancer (NSCLC) as it is the most common type of lung cancer.

9p vischultz 20-10-2023 1 1   Download

This study surveyed circular RNA CCT3 in bladder cancer (BCa). We recruited 85 BCa patients and 40 normal controls (Normal) and collected clinical specimens for analysis. circRNA CCT3 expression was analyzed by RT-qPCR, diagnostic accuracy was calculated by ROC curves, and survival outcomes were evaluated by survival curves.

11p visharma 20-10-2023 5 2   Download

The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marker of plexiform fibromyxoma and gastroblastoma; however, the function of this fusion gene remains unexplored.

12p visharma 20-10-2023 2 2   Download