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Different metalloproteinases
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It is widely accepted that chronic inflammatory bowel diseases significantly higher a risk for colorectal cancer development. Among different types of treatments for patients with colon cancer, novel protein-based thera‑ peutic strategies are considered. AIM To explore the effect of human plasma alpha-1 antitrypsin (AAT) protein in the chemically induced mouse model of colorectal cancer.
14p
vioracle
29-09-2023
5
2
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The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metalloproteinases, metalloproteinase inhibitors, and cytokines affecting them may contribute to this imbalance and destruction of the lung parenchyma.
10p
vimontana2711
05-04-2021
7
2
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The objective of this study was to evaluate the extent of stromal cell-derived factor-1’s (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations.
10p
vitennessee2711
02-02-2021
12
2
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Cancer invasion and metastasis develops through a series of steps that involve the loss of cell to cell and cell to matrix adhesion, degradation of extracellular matrix and induction of angiogenesis. Different protease systems (e.g., matrix metalloproteinases, MMPs) are involved in these steps.
14p
virose2711
24-09-2020
10
0
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ADAM12-L and ADAM12-S represent two major splice variants of human metalloproteinase-disintegrin 12 mRNA, which differ in their 3′-untranslated regions (3′UTRs). ADAM12-L, but not ADAM12-S, has prognostic and chemopredictive values in breast cancer.
13p
vialabama2711
21-09-2020
4
0
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Metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs) are involved in several key pathways of tumor growth, invasion and metastasis, but little is known about their expression according to different molecular subtypes of breast cancer.
10p
vialabama2711
21-09-2020
13
1
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ADAMTS (A Disintegrin and Metalloproteinase with Thrombo-spondin Motifs) are zinc dependent proteases have a part in impor-tant physiologic processes such as development, homeostasis and fertility. To date, 19 different ADAMTS proteases have been iden-tified. ADAMTS-2 is a member of ADAMTS family. Together with ADAMTS-3 and ADAMTS-14, ADAMTS-2 has procollagen N-proteinase activity.
372p
cosis54
05-01-2013
53
4
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Using the CalSIM model, we predict changes in coverage in California as a result of the ACA. Take up of available coverage options in the model is based on a wide range of factors, including the pre-policy starting point, health status, household income, change in cost to purchase coverage, and English proficiency. For Medi-Cal, we assume that 61 percent of uninsured newly eligible individuals, and 10 percent of those who were previously eligible but not enrolled, enroll under our base scenario. is assumption is based on current Medi-Cal take up in the state.
8p
thankinhphanliet
01-01-2013
46
4
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