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Digital sequencing
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Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a systematic review and meta-analysis to summarize the clinical applicability of the next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) technology on the ctDNA detection of the EC and listed the current challenges.
12p
vikoch
27-06-2024
1
1
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The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation Cloud (HRIC) within this environment should enable data sharing and analysis for health research across the EU.
14p
vibransone
28-03-2024
6
2
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Infectious disease control is experiencing a paradigm shift, as pathogen sequencing technologies and digital applications are increasingly implemented for control of diseases such as tuberculosis, Ebola.
3p
vibransone
28-03-2024
3
2
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Ebook "Digital design and computer architecture" is suitable for a rapid-paced, single-semester introduction to digital design and computer architecture or for a two-quarter or two-semester sequence giving more time to digest the material and experiment in the lab. The only prerequisite is basic familiarity with a high-level programming language such as C, C++, or Java.
561p
tichhythan
17-08-2023
7
4
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Continued part 1, part 2 of ebook "Creative sequencing techniques for music production: A practical guide for logic, digital performer, cubase and pro tools" has presents the following content: advanced sequencing techniques; advanced quantization techniques; advanced editing techniques; MIDI system exclusive messages - the "MIDI dump" function; elements of MIDI orchestration; the final mix; reverberation and ambience effects; list of examples contained on the CD-ROM;...
166p
dieptieuung
20-07-2023
4
4
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Part 1 of ebook "Creative sequencing techniques for music production: A practical guide for logic, digital performer, cubase and pro tools" has presents the following content: studio setup; the MIDI devices - controllers, synthesizers, sound modules, and sequencers; connecting the MIDI devices - daisy chain and star network setups; basic sequencing techniques; basic MIDI editing techniques; basic principles of MIDI note quantization; audio track basics; basic automation; intermediate sequencing techniques;...
158p
dieptieuung
20-07-2023
4
3
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3D animation software is extensively used to create graphics for special effects sequences in live-action films, in animated feature film production and for the generation of computer games and virtual reality content. It is a commonly held view within the computer graphics community that 3D animation software is ―just another tool‖ for self-expression. This research questions that view by examining the inherent nature of the tool itself. In doing so, some of the philosophical assumptions embedded in the design of the new digital tool are revealed.
99p
runthenight05
01-03-2023
6
2
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Lecture Digital Logic & Design: Lesson 18 provide students with knowledge about combinational functional devices; MUX applications: 2-digit decimal display circuit (fig 5), common cathode/anode displays (fig 6), 2-digit mux based display circuit (fig 7);...
5p
hanthienngao
15-04-2022
9
1
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Lecture Digital Logic & Design: Lesson 27 provide students with knowledge about sequential logic; asynchronous counters: down counters (fig 1), down counter with truncated sequence (fig 2); synchronous counters: synchronous counter (fig 3), synchronous decade counter (tab 1 fig 6);...
5p
hanthienngao
15-04-2022
14
1
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Lecture Digital Logic & Design: Lesson 28 provide students with knowledge about synchronous decade counter; timing diagram of a synchronous decade counter; 74HC163 4-bit synchronous counter; timing diagram of the 74HC163 synchronous counter; cascaded decade counters;...
18p
hanthienngao
15-04-2022
12
1
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Immune checkpoint inhibitors (ICIs) are currently one of the most promising therapy options in the field of oncology. Although the first pivotal ICI trial results were published in 2011, few biomarkers exist to predict their therapy outcome. PD-L1 expression and tumor mutational burden (TMB) were proven to be sometimes-unre‑ liable biomarkers.
13p
vielonmusk
21-01-2022
12
1
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Although software tools abound for the comparison, analysis, identification, and classification of genomic sequences, taxonomic classification remains challenging due to the magnitude of the datasets and the intrinsic problems associated with classification.
21p
visilicon2711
20-08-2021
4
1
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"Handbook of applied cryptography" present overview of cryptography; mathematical background; number-theoretic reference problems; public-key parameters; pseudorandom bits and sequences; stream ciphers; block ciphers; public-key encryption; hash functions and data integrity; digital signatures; key establishment protocols; key management techniques; efficient implementation; patents and standards; bibliography of papers from selected cryptographic forums....
794p
haphuonglan2021
25-04-2021
41
14
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RNA-seq, a massive parallel-sequencing-based transcriptome profiling method, provides digital data in the form of aligned sequence read counts. The comparative analyses of the data require appropriate statistical methods to estimate the differential expression of transcript variants across different cell/tissue types and disease conditions.
12p
viwyoming2711
16-12-2020
13
0
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The widespread adoption of high throughput technologies has democ‑ ratized data generation. However, data processing in accordance with best practices remains challenging and the data capital often becomes siloed.
18p
viwyoming2711
16-12-2020
5
0
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Recent advances in deep digital sequencing have unveiled an unprecedented degree of clonal heterogeneity within a single tumor DNA sample. Resolving such heterogeneity depends on accurate estimation of fractions of alleles that harbor somatic mutations.
12p
vikentucky2711
26-11-2020
9
1
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In the last years, applications based on massively parallelized RNA sequencing (RNA-seq) have become valuable approaches for studying non-model species, e.g., without a fully sequenced genome. RNA-seq is a useful tool for detecting novel transcripts and genetic variations and for evaluating differential gene expression by digital measurements.
9p
vioklahoma2711
19-11-2020
11
0
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Single cell RNA sequencing (scRNA-seq) brings unprecedented opportunities for mapping the heterogeneity of complex cellular environments such as bone marrow, and provides insight into many cellular processes.
16p
vijisoo2711
27-10-2020
12
0
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Chapter 11 introduces the register transfer methodology, which describes system operation by a sequence of data transfers and manipulations among registers, and demonstrates the construction of the data path (a regular sequential circuit) and the control path (an FSM) used in this methodology.
66p
nanhankhuoctai8
23-06-2020
11
1
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After studying this chapter you will be able to understand: described how memory stores data, instructions, and information, and discussed the sequence of operations that occur when a computer executes an instruction. The chapter included a comparison of various microprocessors on the market today.
27p
nanhankhuoctai8
23-06-2020
12
2
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