Dinucleoside

Novel properties of the primer independent synthesis of poly(A), catalyzed by the yeast poly(A) polymerase are presented.The commercial enzyme fromyeast, incontrast to theenzymefromEscherichia coli, is unable to adenylate the 3¢-OH end of nucleosides, nucleotides or dinucleoside poly-phosphates (NpnN).

7p tumor12 22-04-2013 33 3   Download

Adenosine 5¢-polyphosphates have been identified in vitro, as products of certain enzymatic reactions, andin vivo. Although the biological role of these compounds is not known, there exist highly specific hydrolases that degrade nucleoside 5¢-polyphosphates into the corresponding nucleoside 5¢-triphos-phates.

10p dell39 27-03-2013 45 3   Download

Dinucleoside polyphosphates (NpnN¢s; where N and N¢ are nucleosides andn= 3–6 phosphate residues) are naturally occurring compounds that may act as signaling molecules. One of the most successful approaches to understand their biological functions has been through the use of NpnN¢ analogs.

11p vinaphone15 27-02-2013 42 3   Download