Direct toxic action

Oxaliplatin is a chemotherapeutic agent with direct toxic action on deoxyribonucleic acid (DNA), which is known to cause an arrest in its synthesis and inducing cell death. It is a crucial medication for colorectal carcinoma, and in combination with other medications has demonstrated to exhibit synergism, managing to increase patients’ survival, especially when compared to monotherapy with 5-fluoracil.

3p viintuit 26-09-2023 4 0   Download

Zinc phosphide is a highly effective rodenticide used widely to protect grain in stores and domestically to kill rodents. Acute poisoning may be direct by ingestion or indirect through accidental inhalation of phosphine gas generated during its use.

8p kethamoi1 20-11-2019 37 0   Download

Streptococcal Toxic Shock Syndrome: Treatment In light of the possible role of pyrogenic exotoxins or other streptococcal toxins in streptococcal TSS, treatment with clindamycin has been advocated by some authorities (Table 130-3), who argue that, through its direct action on protein synthesis, clindamycin is more effective in rapidly terminating toxin production than penicillin—a cell-wall agent. Support for this view comes from studies of an experimental model of streptococcal myositis, in which mice given clindamycin had a higher rate of survival than those given penicillin.

5p colgate_colgate 21-12-2010 85 3   Download

Introduction: Diazine and triazine herbicides are being widely used in the world. These herbicides inhibit the electron-transport system in the higher plants and thus suppress the photosynthesis, resulting in the herbicidal action. These compounds are also important as pollutants for crops, soil and groundwater [1, 2]. The attention is usually directed toward chronic toxicities of the herbicides [3].

8p bigbaby87 01-09-2010 78 8   Download