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Discovering novel interactions
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Ebook "Aminoacyl-tRNA synthetases in biology and medicine" will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
355p
nhanphanguyet
28-01-2024
6
2
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In cancer, mutually exclusive or co-occurring somatic alterations across genes can suggest functional interactions. Existing tests for such patterns make the unrealistic assumption of identical gene alteration probabilities across tumors. We present Discrete Independence Statistic Controlling for Observations with Varying Event Rates (DISCOVER), a novel test that is more sensitive than other methods and controls its false positive rate.
17p
vialfrednobel
29-01-2022
11
0
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Elucidation of interactive relation between chemicals and genes is of key relevance not only for discovering new drug leads in drug development but also for repositioning existing drugs to novel therapeutic targets.
17p
viwyoming2711
16-12-2020
12
1
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Discovering novel interactions between HIV-1 and human proteins would greatly contribute to different areas of HIV research. Identification of such interactions leads to a greater insight into drug target prediction. Some recent studies have been conducted for computational prediction of new interactions based on the experimentally validated information stored in a HIV-1-human protein-protein interaction database.
22p
vikentucky2711
26-11-2020
13
1
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A large body of evidence shows that miRNA regulates the expression of its target genes at posttranscriptional level and the dysregulation of miRNA is related to many complex human diseases. Accurately discovering disease-related miRNAs is conductive to the exploring of the pathogenesis and treatment of diseases.
14p
vicolorado2711
23-10-2020
10
0
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Aiming to discover novel molecules with highly-efficient agricultural activities, a series of penta-1,4-diene3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffolds were synthesized and evaluated for their antiviral activities.
12p
vijiraiya2711
27-05-2020
12
1
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The molecular mechanism of the presynaptic neurotoxicity of snake venom phospholipases A2(PLA2s) is not yet fully elucidated. Recently, newhigh-affinity binding proteins for PLA2 toxins have been discovered, including the important intracellular Ca 2+ sensor, calmodulin (CaM). In the present study, the mode of interaction of group IIAPLA2swiththe Ca 2+ -bound form of CaM was investigated by mutational analysis of ammodytoxin A (AtxA) from the long-nosed viper (Vipera ammodytes ammodytes).
8p
fptmusic
16-04-2013
31
2
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