Disease progression

Dental caries is the most prevalent chronic childhood disease with numerous predisposing factors. Salivary properties have been linked to progressive dental caries in previous studies. However, the role of these contributing factors in the management of dental caries in children remains insufficient. Thus, the investigation of salivary characteristics from different types of communities within a specific pediatric population is an obvious demand.

7p vinara 11-01-2025 0 0   Download

Anxiety disorder is one of the issue that affects the patient's physical and mental health and reduces the effectiveness of treatment. At the moment, patients with underlying conditions, particularly those with hypertension, are more likely to experience anxiety problems. This lessens quality of life, accelerates disease progression, exacerbates illness symptoms, and decreases treatment compliance rates.

7p vinara 11-01-2025 0 0   Download

Hepatitis B infection remains a global health problem, with progression to acute-chronic hepatitis, severe liver failure, and death making hepatitis B one of the most serious infections worldwide. The disease is most widely transmitted from an infected mother to her baby, after exposure to infected blood or body fluids or unsafe sexual contact.

6p viharuno 03-01-2025 1 1   Download

In patients with end-stage chronic kidney failure, there are a number of disorders that cause bone damage. In this article we present a case of secondary HPT causing facial and thoracic bone changes.

6p viharuno 03-01-2025 1 1   Download

Early prediction of ovarian cancer has not been given much attention, the application of combined models in clinical practice is not widespread, and the calculation of these models is still difficult due to the complexity and multiple variables.

8p viharuno 03-01-2025 1 1   Download

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

8p kethamoi1 17-11-2019 30 2   Download

Dystrobrevin is one of the intracellular components of the transmembrane dystrophin–glycoprotein complex (DGC). The functional role of this complex in normal and pathological situations has not yet been clearly established. Dystrobrevin disappears from the muscle membrane in Duchenne muscular dystrophy (DMD), which results from dystrophin mutations, as well as in limb girdle muscular dystrophies (LGMD), which results from mutations affecting other members of the DGC complex.

6p system191 01-06-2013 36 5   Download

Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.

11p fptmusic 12-04-2013 32 2   Download

Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by multifarious dysfunctional alterations including mitochon-drial impairment. In the present study, the formation of inclusions caused by the mutation of huntingtin protein and its relationship with changes in energy metabolism and with pathological alterations were investigated both in transgenic and 3-nitropropionic acid-treated mouse models for HD.

16p inspiron33 23-03-2013 38 6   Download

Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease that usually manifests itself within the fifth decade. The most prom-inent symptoms are progressive ptosis, dysphagia, and proximal limb mus-cle weakness. The disorder is caused by trinucleotide (GCG) expansions in the N-terminal part of the poly(A)-binding protein 1 (PABPN1) that result in the extension of a 10-alanine segment by up to seven more alanines.

10p inspiron33 23-03-2013 50 4   Download

Exposure to quartz particles induces a pathological process named silicosis. Alveolar macrophages initiate the disease through their activation, which is the origin of the later dysfunctions. Ascorbic acid is known to selectively dissolve the quartz surface. During the reaction, ascorbic acid progressively disappears and hydroxyl radicals are generated from the quartz surface. These observations may be relevant to mammalian quartz toxicity, as sub-stantial amounts of ascorbic acid are present in the lung epithelium. ...

14p inspiron33 23-03-2013 41 4   Download

Dendritic cells can enhance the replication of HIV-1 in CD4 + lymphocytes through the interaction of the gp120 envelope protein with such molecules as dendritic cell-specific intercellular adhesion molecule-3-grabbing noninte-grin. The variable loops of gp120 have previously been shown to modulate the interaction of HIV-1 with its principal receptor CD4 and its various coreceptors, namely CCR5 and CXCR4.

15p inspiron33 23-03-2013 42 3   Download

Familial amyloidotic polyneuropathy (FAP) is an inherited autosomal dominant disease that is commonly caused by accumulation of deposits of transthyretin (TTR) amyloid around peripheral nerves. The only effective treatment for FAP is liver transplantation.

14p galaxyss3 21-03-2013 50 2   Download

Parkinson’s disease (PD) is a heterogeneous movement disorder character-ized by progressive degeneration of dopamine neurons in substantia nigra. We have previously presented genetic evidence for the possible involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD.

12p galaxyss3 21-03-2013 36 4   Download

The LolCDE complex ofEscherichia colibelongs to the ATP-binding cas-sette transporter superfamily and mediates the detachment of lipoproteins from the inner membrane, thereby initiating lipoprotein sorting to the outer membrane. The complex is composed of one copy each of membrane subunits LolC and LolE, and two copies of ATPase subunit LolD.

17p galaxyss3 19-03-2013 32 3   Download

Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that affects 0.5–1% of the population. RA causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life.

7p galaxyss3 07-03-2013 34 3   Download

Parkinson’s disease (PD), a common progressive neurodegenerative disor-der, is characterized by degeneration of dopamine neurons in the substantia nigra and neuronal proteinaceous aggregates called Lewy bodies (LBs). The etiology of PD is probably a combination of environmental and genetic factors.

8p media19 06-03-2013 27 2   Download

Cells of the innate immune system play important roles in the progression of prion disease after peripheral infection. It has been foundin vivo and in vitro that the expression of the cellular prion protein (PrP c ) is up-regu-lated on stimulation of immune cells, also indicating the functional impor-tance of PrP c in the immune system.

11p media19 05-03-2013 25 3   Download

Since its discovery 10 years ago, Pin1, a prolylcis⁄trans isomerase essential for cell cycle progression, has been implicated in a large number of molecu-lar processes related to human diseases, including cancer and Alzheimer’s disease.

12p media19 04-03-2013 23 1   Download

Friedreich ataxia (FRDA) is a rare hereditary neurodegenerative disease characterized by progressive ataxia and cardiomyopathy. The cause of the disease is a defect in mitochondrial frataxin, an iron chaperone involved in the maturation of Fe–S cluster proteins.

12p vinaphone15 27-02-2013 32 2   Download