Disease progression

In patients with end-stage chronic kidney failure, there are a number of disorders that cause bone damage. In particular, secondary hyperparathyroidism (SHPT) is related to chronic kidney failure, a calcium-phosphorus metabolism disorder that causes bone disorder.

6p viengfa 23-10-2024 1 0   Download

This issue would be a considerable cost burden for these subjects if they do not receive early and timely intervention. Therefore, we conducted this study to evaluate the prevalence of dementia and related factors in the elderly in this location.

8p vibecca 01-10-2024 4 0   Download

The hereditary spastic paraplegias (HSPs) are a group of disorders characterised by progressive lower limb weakness and spasticity. This case highlights the challenge of distinguishing HSP from other chronic spinal cord diseases and emphasizes the role of genetic analysis in rare cases of spastic paraplegia.

4p viling 27-09-2024 2 2   Download

Early detection and correction of calcium-phosphate imbalances to improve symptoms of hyperuremia, slow the progression of chronic kidney disease and reduce the risk of death from cardiovascular complications and renal osteodystrophy dues to secondary hyperparathyroidism.

7p viormkorn 27-09-2024 2 2   Download

Multiple system atrophy (MSA) is a fatally progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia and autonomic dysfunction. The study aimed to describe lower urinary tract symptoms and residual urine volume in early MSA.

7p viormkorn 27-09-2024 5 2   Download

Hepatitis B infection remains a global health problem, with progression to acute-chronic hepatitis, severe liver failure, and death making hepatitis B one of the most serious infections worldwide. The disease is most widely transmitted from an infected mother to her baby, after exposure to infected blood or body fluids or unsafe sexual contact.

6p vifaye 20-09-2024 2 1   Download

Dental caries is the most prevalent chronic childhood disease with numerous predisposing factors. Salivary properties have been linked to progressive dental caries in previous studies. To assess the salivary characteristics among school-going children aged 12 years from two urban and suburban schools in Can Tho city.

7p vinatisu 29-08-2024 3 1   Download

Acute kidney injury is one of the severe conditions in hospitalized patients. Acute kidney injury can develop early from admission, usually within the first 24 hours of ICU admission. This study aims to investigate the incidence, severity, clinical, laboratory characteristics, and progression of acute kidney injury in patients with sepsis and septic shock within the first 48 hours.

7p vinatisu 29-08-2024 7 2   Download

Chronic pancreatitis (CP) is a benign inflammatory disease involving the progressive and irreversible destruction of the pancreatic tissue, fibrosis and loss of exocrine and endocrine function. Clinical management of CP is also challenging because of the incomplete understanding of disease and pain pathogenesis. In Hue Central Hospital, CP is primarily treated with open drainage procedures.

7p vinatisu 29-08-2024 2 1   Download

There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development.

16p vibransone 28-03-2024 7 3   Download

Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to high diagnosis rates at late stages and disease relapses. New avenues of therapy are needed that target key processes in ovarian cancer progression.

20p vimichaelfaraday 25-03-2022 16 1   Download

Chromatin state provides a clear decipherable blueprint for maintenance of transcriptional patterns, exemplifying a mitotically stable form of cellular programming in dividing cells. In this regard, genomic studies of chromatin states within cancerous tissues have the potential to uncover novel aspects of tumor biology and unique mechanisms associated with disease phenotypes and outcomes.

15p vielonmusk 21-01-2022 14 1   Download

Circular RNAs (circRNAs) are more stable than linear RNA molecules, which makes them promising diagnostic biomarkers for diseases. By circRNA-sequencing analysis, we previously found that circN4BP2L2 was significantly decreased in epithelial ovarian cancer (EOC) tissues, and was predictive of disease progression.

15p vielonmusk 21-01-2022 25 0   Download

We sought to understand the clinical course and molecular phenotype of patients who showed disease progression after programmed cell death ligand 1 (PD-L1) inhibitor treatment but subsequently responded to PD-1 inhibitor treatment. We also explored the response to PD-1-axis targeted therapy of classical Hodgkin lymphoma (cHL) according to genetically driven PD-L1 and programmed cell death ligand 2 (PD-L2) expression.

8p vielonmusk 21-01-2022 15 1   Download

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

8p kethamoi1 17-11-2019 29 2   Download

Dystrobrevin is one of the intracellular components of the transmembrane dystrophin–glycoprotein complex (DGC). The functional role of this complex in normal and pathological situations has not yet been clearly established. Dystrobrevin disappears from the muscle membrane in Duchenne muscular dystrophy (DMD), which results from dystrophin mutations, as well as in limb girdle muscular dystrophies (LGMD), which results from mutations affecting other members of the DGC complex.

6p system191 01-06-2013 34 5   Download

Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.

11p fptmusic 12-04-2013 30 1   Download

Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by multifarious dysfunctional alterations including mitochon-drial impairment. In the present study, the formation of inclusions caused by the mutation of huntingtin protein and its relationship with changes in energy metabolism and with pathological alterations were investigated both in transgenic and 3-nitropropionic acid-treated mouse models for HD.

16p inspiron33 23-03-2013 38 6   Download

Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease that usually manifests itself within the fifth decade. The most prom-inent symptoms are progressive ptosis, dysphagia, and proximal limb mus-cle weakness. The disorder is caused by trinucleotide (GCG) expansions in the N-terminal part of the poly(A)-binding protein 1 (PABPN1) that result in the extension of a 10-alanine segment by up to seven more alanines.

10p inspiron33 23-03-2013 49 4   Download

Exposure to quartz particles induces a pathological process named silicosis. Alveolar macrophages initiate the disease through their activation, which is the origin of the later dysfunctions. Ascorbic acid is known to selectively dissolve the quartz surface. During the reaction, ascorbic acid progressively disappears and hydroxyl radicals are generated from the quartz surface. These observations may be relevant to mammalian quartz toxicity, as sub-stantial amounts of ascorbic acid are present in the lung epithelium. ...

14p inspiron33 23-03-2013 41 4   Download