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Báo cáo khoa học: Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrinexpressing cells is influenced by gp120 envelope modifications associated with disease progression

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:15

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Dendritic cells can enhance the replication of HIV-1 in CD4 + lymphocytes through the interaction of the gp120 envelope protein with such molecules as dendritic cell-specific intercellular adhesion molecule-3-grabbing noninte-grin. The variable loops of gp120 have previously been shown to modulate the interaction of HIV-1 with its principal receptor CD4 and its various coreceptors, namely CCR5 and CXCR4.

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Nội dung Text: Báo cáo khoa học: Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrinexpressing cells is influenced by gp120 envelope modifications associated with disease progression

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