Disease relapse
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The present study aims to investigate the dynamic of plasma EVs in meningioma patients during radiotherapy and subsequent follow-up, which may serve as biomarker in treatment response and disease monitoring (e.g. early detection of relapse).
6p vishanshan 27-06-2024 2 1 Download
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Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined.
13p vishanshan 27-06-2024 1 1 Download
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The book is organized on the basis of concepts that have guided our research in the field for some time, but particularly the concept that addiction is a chronically relapsing disorder characterized by: A compulsion to seek and take drugs; Loss of control over drug intake; Emergence of a negative emotional state (e.g., dysphoria, anxiety, and irritability) that defines a motivational withdrawal syndrome when access to the drug is prevented.
339p vimeyers 29-05-2024 3 2 Download
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Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.
4p vibransone 28-03-2024 4 2 Download
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Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell typespecific transcriptomic changes over the clinical course of the disease using single-cell RNA sequencing (scRNA-seq).
21p vibransone 28-03-2024 3 2 Download
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Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disease of the gastrointestinal tract which includes ulcerative colitis and Crohn's disease. Genetic risk factors for IBD are not well understood.
11p vioraclene 31-03-2024 3 2 Download
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Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.
18p vicwell 29-02-2024 5 1 Download
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Extranodal, natural-killer/T-cell lymphoma of nasal type is a rare but aggressive disease usually presenting as progressive necrotic lesions in the nasal cavity that responds poorly to chemotherapy. In this paper, we report a relapsing, chemorefractory case of extranodal natural-killer/T-cell lymphoma responding to checkpoint inhibitor immunotherapy with pembrolizumab.
7p vilazada 31-01-2024 2 2 Download
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Granulomatosis with polyangiitis and relapsing polychondritis are rare, multisystemic and potentially life-threatening connective tissue diseases. We present two cases of severe endobronchial obstruction in the aforementioned conditions and discuss difficulties with detection and treatment.
4p vitiki 30-01-2024 4 2 Download
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This study was designed to investigate the frequency and clinicopathological characteristics of POLEmutated/ultramutated (POLEmut) in endometrial carcinoma (EC) and assess the prognostic values of POLE status.
15p vileonardodavinci 23-12-2023 2 2 Download
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For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients will relapse and die. Many UK patients present with advanced disease which is already inoperable or metastatic at diagnosis.
13p vileonardodavinci 23-12-2023 5 3 Download
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Severe graft versus host disease (GVHD) is the main reason for non-relapse mortality following allogeneic hematopoietic cell transplantation (HCT). We investigated the serum protein profles of patients who had undergone HCT to identify predictive biomarkers of severe acute GVHD (aGVHD).
12p vialfrednobel 23-12-2023 5 3 Download
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Venetoclax is clinically active in treating relapsed/refractory multiple myeloma (RRMM). This study evaluated the efficacy and safety of venetoclax or venetoclax with other agents in treating RRMM.
9p vialfrednobel 23-12-2023 3 2 Download
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The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, we examined whether the time interval between surgery and the first disease relapse may affect survival outcomes in Taiwanese patients with OCSCC.
17p vischultz 20-10-2023 5 1 Download
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Part 2 book "Human diseases from wildlife" includes content: Tick borne relapsing fever, rocky mountain spotted fever and other spotted fevers, Q-fever and coxiellosis, epidemic typhus and murine typhus, ehrlichiosis and anaplasmosis, rabies, equine encephalitis - eastern, western, and venezuelan, west nile virus and other diseases caused by flaviviruses: yellow fever, dengue, ST. Louis encephalitis, japanese encephalitis, powassan encephalitis, and deer tick virus,... and other contents.
288p oursky06 17-10-2023 3 2 Download
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Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced urothelial carcinoma (UC) in the frontline and relapsed settings. Lebanon has one of the highest incidence of UC worldwide, yet no data exists regarding the expression of PD-L1 by Combined Positive Score (CPS) in advanced disease.
6p vioracle 29-09-2023 5 3 Download
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Two thirds of patients with germ-cell cancer (GCC) present as clinical stage I (CSI). Following orchiectomy, active surveillance (AS) has become their standard management. However, 15–50% of patients eventually relapse with metastatic disease after AS. Relapses need to be detected early in order to achieve cure and avoid overtreatment.
8p vioracle 29-09-2023 5 2 Download
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Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells. The diagnosis of this disease is often suspected through a constellation of clinical signs and symptoms of hypercalcemia, renal failure, anemia, and M-spike proteins.
4p viintuit 26-09-2023 3 0 Download
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Atypical hemolytic uremic syndrome is a thrombotic microangiopathy that can cause life-threatening anemia, thrombocytopenia, and acute renal failure. When triggered during pregnancy or the acute postpartum period, the disease is referred to as pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS).
2p viintuit 26-09-2023 0 0 Download
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Lung involvement in inflammatory bowel diseases usually follows colitis. However, the time to lung involvement onset varies depending on the case, and pulmonary lesions are usually not parallel to exacerbations of the colitis.
6p vigamora 23-05-2023 4 2 Download