Diverse biological activity

The main components of black ginger (Kaempferia parviflora Wall ex Baker.) show diverse biological effects, especially potential ancancer activity. Thirty-five bioactive compounds were screened for ancancer activity by molecular docking with AutoDock Vina software on VEGFR2 kinase.

10p viling 11-10-2024 0 0   Download

Flavonoids are a diverse group of natural compounds extensively studied in various research articles. They are widely distributed in the plant kingdom and exhibit various biological activities, including antioxidant, antiinflammatory, anticancer, antiviral, and antimicrobial effects. The genus Knema Lour., which contains many species in Southeast Asia, has been traditionally used to treat various ailments. The current review aims to provide a comprehensive update on the isolation of flavonoids and other secondary metabolites from the genus Knema Lour. between 1978 and 2022.

15p dianmotminh02 03-05-2024 10 4   Download

An understanding of soil microorganisms as part of soil system and interactions between the diversity of producers and of decomposers, have major consequences on the functioning of agricultural ecosystems. Soil microorganisms control the transformation and mineralization of natural compounds and xenobiotics. The soil micro biota, existing in high density and diversity, rapidly modify the energetic performance and activity rates to changing environmental conditions.

9p nguaconbaynhay6 24-06-2020 20 1   Download

The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated.

8p tocectocec 25-05-2020 9 0   Download

Murine double minute 2 (MDM2) protein exhibits many diverse biochemi-cal functions on the tumour suppressor protein p53, including transcrip-tional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit ATP-dependent molecular chap-erone activity and directly mediate folding of the p53 tetramer. Analysing the ATP-dependent function of MDM2 will provide novel insights into the evolution and function of the protein.

12p research12 29-04-2013 61 4   Download

Multi-protein complexes are emerging as important entities of biological activity inside cells that serve to create func-tional diversity by contextual combination of gene products and, at the same time, organize the large number of different proteins into functional units. Many a time, when studying protein complexes rather than individual proteins, the bio-logical insight gained has been fundamental, particularly in cases in which proteins with no previous functional anno-tation couldbe placed intoa functional context derived from their
molecular environment. ...

9p tumor12 20-04-2013 37 2   Download

Structural elucidation of the lipopolysaccharide (LPS) from three nontypeable Haemophilus influenzaeclinical isolates, 1209, 1207 and 1233 was achieved using NMR spectro-scopy and ESI-MS on O-deacylated LPS and core oligo-saccharide (OS) material as well as ESI-MS n on permethylated dephosphorylated OS. It was found that the organisms expressed a tremendous heterogeneous glyco-form mixture resulting from the variable length of the OS chains attached to the common structural element of H.

15p tumor12 20-04-2013 35 2   Download

The protein tyrosine phosphatase PTP-Basophil (PTP-Bas) and itsmouse homologue, PTP-Basophil-like (PTP-BL), are high molecular mass protein phosphatases consisting of a number of diverse protein–protein interaction modules. Several splicing variants of these phosphatases are known to exist thus demonstrating the complexity of these molecules. PTP-Bas/BL serves as a central scaffolding protein facilita-ting the assembly of a multiplicity of different proteins mainly via five different PDZ domains. ...

10p fptmusic 12-04-2013 36 2   Download

Tobacco pathogenesis-related protein 1a (PR-1a) is induced in plants during the hypersensitive response (HR) after exposure of plants to salicylic acid (SA) and by develop-mental cues.Gene activation by these diverse stimuli is mediated via anas-1-like element in the PR-1aupstream region.To further analyze the significance of thiscis-acting sequence, an authentic as-1element from the cauliflower mosaic virus 35S RNA promoter was inserted into the PR-1apromoter in place of theas-1-like motif.

11p fptmusic 12-04-2013 35 3   Download

The (ba)8-barrel is the most common enzyme fold and it is capable of cata-lyzing an enormous diversity of reactions. It follows that this scaffold should be an ideal starting point for engineering novel enzymes by directed evolution. However, experiments to date have utilized in vivo screens or selections and the compatibility of (ba)8-barrels with in vitro selection methods remains largely untested.

14p fptmusic 11-04-2013 41 3   Download

To explore the venom diversity of Asian pit vipers, we investigated the structure and function of venom phospholipase A2 (PLA2) derived from two primitive tree vipers Trimeresurus puniceusandTrimeresurus borneen-sis. We purified six novel PLA2s fromT. puniceusvenom and another three from T. borneensisvenom. All cDNAs encoding these PLA2s except one were cloned, and the molecular masses and N-terminal sequences of the purified enzymes closely matched those predicted from the cDNA.

0p awards 06-04-2013 47 2   Download

Enzyme catalysis in low water containing organic solvents is finding an increasing number of applications in diverse areas.This review focuses on some aspects which have not been reviewed elsewhere.Different strategies for obtaining higher activity and stability in such media are described.In this context, the damaging role of lyophilization and the means of overcoming such effects are discussed.Ultrasoni-cation and microwave assistance are two emerging approa-ches for enhancing reaction rates in low water media.

9p dell39 03-04-2013 62 4   Download

Cone snails comprise
500 species of venomous molluscs, which have evolved the ability to generate multiple toxins with varied and often exquisite selectivity. One class, the a-conotoxins, is proving to be a powerful tool for the differentiation of nicotinic acetylcholine receptors (nAChRs). These comprise a large family of complex subtypes, whose significance in physiological functions and pathological conditions is increasingly becoming apparent.

15p dell39 03-04-2013 47 4   Download

Nitric oxide (NO • ) has been proposed to be a physiological modulator of cell proliferation, able to promote in most cases cell cycle arrest. In this review I explore the molecular basis of this mechanism of action. The mod-ulatory action of NO • on the intracellular concentration of cGMP and the machinery directly involved in the control of cell cycle progression, inclu-ding the expression and activity of diverse cyclins and cyclin-dependent kinases,

16p inspiron33 26-03-2013 49 4   Download

U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF 65 and U2AF 35 . During the past few years, a number of proteins related to both U2AF 65 and U2AF 35 have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence.

10p inspiron33 23-03-2013 46 4   Download

Actin is one of the most abundant proteins in nature. It is found in all eukaryotes and plays a fundamental role in many diverse and dynamic cellular processes. Also, actin is one of the most ubiquitous proteins because actin-like proteins have recently been identified in bacteria.

16p galaxyss3 07-03-2013 52 4   Download

Prokineticins are a novel family of secreted peptides with diverse regulatory roles, one of which is their capacity to modulate immunity in humans and in other species. Prokineticins are small peptides of 8 kDa that mediate their biological activities by signaling through two homologous G-protein-coupled receptors (prokineticin receptor 1 and prokineticin receptor 2).

8p galaxyss3 07-03-2013 41 3   Download

The small G protein Rap1 regulates diverse cellular processes such as inte-grin activation, cell adhesion, cell–cell junction formation and cell polarity. It is crucial to identify Rap1 effectors to better understand the signalling pathways controlling these processes.

15p media19 04-03-2013 32 1   Download

Host-derived anti-infective proteins represent an important source of sequences for designing antimicrobial peptides (AMPs). However such sequences are often long and comprise diverse amino acids with uncertain contribution to biological effects. Previously, we identified a simple highly cationic peptide derivative of human apolipoprotein E (apoEdp) that inhib-ited a range of microorganisms.

15p media19 04-03-2013 30 3   Download

The prokaryotic genomes, for which complete nucleotide sequences are available, always contain at least one RNase H gene, indicating that RNase H is ubiquitous in all prokaryotic cells. Coupled with its unique substrate specificity, the enzyme has been expected to play crucial roles in the biochemical processes associated with DNA replication, gene expression and DNA repair.

12p vinaphone15 27-02-2013 26 4   Download