DNA adducts

Polycyclic aromatic hydrocarbons (PAHs) are common and persistent environmental pollutants produced during the incomplete combustion of fuels. They are known for their carcinogenic and mutagenic properties. Thus, their removal from water bodies is highly crucial and has become a critical issue globally. As a solution, here an electrospun polycaprolactone (PCL) membrane with a mean fiber diameter of 2.74 ± 1.3 μm was produced by electrospinning. Water contact angle (WCA) analysis confirmed the hydrophobic nature of the PCL membrane with a WCA of 124°, which remained stable over time.

10p lyhuyenthu 31-01-2023 4 1   Download

Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies. Personalized chemotherapy is dependent on the identification and validation of biomarkers that can predict treatment outcome and/or risk of toxicity.

16p vidarwin 22-02-2022 18 1   Download

Nucleotide excision repair is the primary DNA repair mechanism that removes bulky DNA adducts such as UV-induced pyrimidine dimers. Correspondingly, genome-wide mapping of nucleotide excision repair with eXcision Repair sequencing (XR-seq), provides comprehensive profiling of DNA damage repair.

13p vitzuyu2711 29-09-2021 6 1   Download

Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer.

8p vijennie2711 25-09-2020 32 1   Download

The risk of hepatocellular carcinoma (HCC) increases in chronic hepatitis B surface antigen (HBsAg) carriers who often have concomitant increase in the levels of benzo[alpha]pyrene-7,8-diol-9,10-epoxide(±) (BPDE)-DNA adduct in liver tissues, suggesting a possible co-carcinogenesis of Hepatitis B virus (HBV) and benzo [alpha]pyrene in HCC; however the exact mechanisms involved are unclear.

11p virose2711 24-09-2020 7 0   Download

The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively induce cancer cell death, however, there are a range of clinical side effects and drug resistance issues associated with its use.

17p vinaypyidaw2711 26-08-2020 16 1   Download

7, 12-Dimethylbenz[a]anthracene (DMBA) is acting as immunosuppressor and it serves as a tumor initiator. Tumor promotion can be induced with treatments of 12-Otetradecanoylphorbol-13-acetate (TPA) in some models of two-stage carcinogenesis. This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible. The DMBA damages many internal organs including liver, by inducing the production of reactive oxygen species, DNA-adduct formation and affecting the activities of phase I, II, antioxidant and serum enzymes.

15p nguaconbaynhay6 23-06-2020 13 1   Download

Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such as DNA replication and transcription.

16p viputrajaya2711 22-06-2020 10 2   Download

Transcription-coupled nucleotide excision repair (TC-NER) plays a prominent role in the removal of DNA adducts induced by platinum-based chemotherapy reagents.

13p vikuala271 13-06-2020 6 1   Download

Brassica vegetables contain a class of secondary metabolites, the glucosinolates (GS), whose specific degradation products determine the characteristic flavor and smell. While some of the respective degradation products of particular GS are recognized as health promoting substances for humans, recent studies also show evidence that namely the 1-methoxy-indol-3-ylmethyl GS might be deleterious by forming characteristic DNA adducts.

15p viminato2711 22-05-2020 9 0   Download

The benzoacronycine derivative, S23906-1, was character-ized recently as a novel potent antitumor agent through alkylation of theN2 positionof guanines inDNA.We show here that its reactivity towards DNA can be modulated by glutathione (GSH). The formation of covalent adducts between GSH and S23906-1 was evidenced by EI-MS, and the use of different GSH derivatives, amino acids and dipeptides revealed that the cysteine thiol group is absolutely required for complex formation because glutathione disul-fide (GSSG) and other S-blocked derivatives failed to react covalently with S23906-1. ...

12p fptmusic 16-04-2013 38 2   Download

trans-[PtCl2NH3(4-Hydroxymethylpyridine)] (trans-PtHMP) is an analogue of clinically ineffective transplatin, which is cytotoxic in the human leuke-mia cancer cell line. As DNA is a major pharmacological target of anti-tumor platinum compounds, modifications of DNA by trans-PtHMP and recognition of these modifications by active tumor suppressor protein p53 were studied in cell-free media using the methods of molecular biology and biophysics.

14p dell39 27-03-2013 44 2   Download

Benzo[a]pyrene (B[a]P) is a common food pollutant that causes DNA adduct formation and is carcinogenic. The report of a positive correlation between human plasma B[a]P levels and body mass index, together with B[a]P’s lipophilicity, led us to test for possible adverse effects of B[a]P on adipose tissue.

11p inspiron33 26-03-2013 46 4   Download

Deoxyribonuclease I (DNase I) footprinting methodology was used to analyze oligodeoxyribonucleotide duplexes containing unique and single, site-specific adducts of trinuclear bifunctional platinum compound, [{trans-PtCl(NH3 )2}2l-trans-Pt(NH3 )2{H2N(CH2 )6NH2}2 ] 4+ (BBR3464) and the results were compared with DNase I footprints of some adducts of con-ventional mononuclearcis-diamminedichloroplatinum(II) (cisplatin).

12p inspiron33 25-03-2013 43 2   Download

The biologically most significant genotoxic metabolite of the environmental pollutant benzo[a]pyrene (B[a]P), (+)-7R,8S-diol 9S,10R-epoxide, reacts chemically with guanine in DNA, resulting in the predominant formation of (+)-trans-B[a]P-N 2 -dG and, to a lesser extent, (+)-cis-B[a]P-N 2 -dG adducts.

14p galaxyss3 19-03-2013 29 2   Download

Hai chủ đề thường được khám phá trong triển lãm của các độc tố sinh hóa: bản chất của sự thay đổi sinh hóa và chế độ độc hại của hành động. So với bản chất của sự thay đổi, thay đổi sinh hóa chẳng hạn như những người liên quan đến monooxygenases cytochrome P450, metallothioneins, hoặc các protein căng thẳng được xem xét trong bối cảnh giải độc độc tố nói chung, hiện tượng hấp thụ. Các thay đổi khác như DNA adduct hình thành, sự ức chế enzyme, hoặc peroxy lipid có thể được xem như là bằng...

19p giangsinh_trang 03-01-2012 51 3   Download