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DNA aneuploidy
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Hiện tượng lệch bội nhiễm sắc thể ở phôi là một trong những nguyên nhân chính gây thất bại làm tổ, sẩy thai liên tiếp, làm giảm hiệu quả điều trị thụ tinh trong ống nghiệm. Xét nghiệm di truyền phôi tiền làm tổ phát hiện phôi lệch bội (Preimplantation Genetic Testing for Aneuploidy) giúp sàng lọc, phát hiện các phôi mang bất thường về số lượng nhiễm sắc thể bằng cách thu nhận 5-10 tế bào lá nuôi phôi (Trophectoderm).
5p
vilouispasteur
10-03-2022
31
4
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Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. These data point to novel biological mechanisms in DS and have general implications for trans effects of chromosomal duplications and aneuploidies on epigenetic patterning.
26p
viaristotle
29-01-2022
8
0
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Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a subset of cells in a sample; this is known as “mosaic” aneuploidy. A cell that harbours an aneuploidy exhibits disrupted gene expression patterns which can alter its behaviour. However, detection of aneuploidies using conventional single-cell DNA-sequencing protocols is slow and expensive.
8p
vilarryellison
29-10-2021
15
1
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Detection of DNA copy number alterations (CNAs) is critical to understand genetic diversity, genome evolution and pathological conditions such as cancer. Cancer genomes are plagued with widespread multi-level structural aberrations of chromosomes that pose challenges to discover CNAs of different length scales, and distinct biological origins and functions.
22p
vicolorado2711
22-10-2020
8
0
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DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA ploidy status on the survival of gastric cancer patients.
8p
vikuala271
13-06-2020
6
1
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Genetic information is physically carried on large DNA strings that are organized into chromosomes. Each species is characterized by a chromosome set that carry the information necessary and sufficient for its development and survival. Eukaryotic organisms are mostly diploid, containing two sets of chromosomes with each pair carrying nearly identical genetic information. Occasionally, exceptions to this rule are found, such as haploid yeast (with only one set of chromosomes) or polyploid ferns and frogs (with multiple sets).
256p
wqwqwqwqwq
09-07-2012
60
11
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: DNA aneuploidy as a topographic malignant transformation pattern in a pleomorphic adenoma of long-term evolution: a case report
7p
toshiba24
06-12-2011
47
3
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