DNA-binding

DNA binding with one finger (Dof) transcription factors play important roles in plant growth and abiotic stress responses. Although genome-wide identification and analysis of the DOF transcription factor family has been reported in other species, no relevant studies have emerged in wheat.

18p vijeeni2711 24-07-2021 11 0   Download

Jurkat T lymphocytes were treated with daunorubicin and WP631, a daunorubicin-based DNAbinding agent, in experiments aimed to analyze cellular uptake of these drugs and their effect on cell viability. WP631 was taken up more slowly than daunorubicin, but laser confocal microscopy and spectrofluorometricquantificationshowed that thedrug accumulated in the cells. Despite the slow uptake rate, the antiproliferative capacity of WP631 (measured as IC50after a 72-h continuous treatment) was greater than that of daunorubicin.

7p tumor12 20-04-2013 38 5   Download

The HIVEP gene family encodes for very large sequence-specific DNAbinding proteins containing multiple zinc fingers. Three mammalian paralogous genes have been identified, HIVEP1,-2and -3, as well as the closely related Drosophilagene,Schnurri. These genes have been found to directly participate in the transcriptional regulation of a variety of genes. Mammalian HIVEP members have been implicated in signaling by TNF-aand in the positive selec-tion of thymocytes, whileSchnurrihas been shown to be an essential component of theTGF-bsignalingpathway. ...

10p dell39 03-04-2013 32 3   Download