![](images/graphics/blank.gif)
DNA microarrays
-
Profiles of DNA methylation of many tissues relevant in human disease have been obtained from microarrays and are publicly available. These can be used to generate maps of chromatin compartmentalization, demarcating open and closed chromatin across the genome. Additionally, large sets of genome-wide transcription factor binding profiles have been made available thanks to ChIP-seq technology.
11p
vioraclene
31-03-2024
3
2
Download
-
Molecular autopsy refers to DNA-based identification of the cause of death. Despite recent attempts to broaden its scope, the term remains typically reserved to sudden unexplained death in young adults. In this study, we aim to showcase the utility of molecular autopsy in defining lethal variants in humans.
11p
vibransone
28-03-2024
3
2
Download
-
Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.
26p
vibransone
28-03-2024
2
2
Download
-
The multiple de novo copy number variant (MdnCNV) phenotype is described by having four or more constitutional de novo CNVs (dnCNVs) arising independently throughout the human genome within one generation. It is a rare peri-zygotic mutational event, previously reported to be seen once in every 12,000 individuals referred for genome-wide chromosomal microarray analysis due to congenital abnormalities.
21p
viellison
28-03-2024
3
2
Download
-
Ebook "Analytics of Protein–DNA interactions (Advances in biochemical engineering/biotechnology, Volume 104)" focuses on the fascinating possibilities that emerged during the last years to study protein–DNA interactions in vitro. As an essential part of transcriptional activity during development and in tumorgenesis a separate chapter describing the analysis of DNA modification especially methylation of cytosines at their carbon-5 position was included.
212p
manmanthanhla0201
27-02-2024
4
2
Download
-
Ebook "Pattern recognition in bioinformatics: 5th IAPR international conference, PRIB 2010 Nijmegen, The Netherlands, September 22-24, 2010 proceedings" has two main objectives: the creation and maintenance of biological databases and the analysis of life sciences data in order to unravel the mysteries of biological function. Computer science methods such as pattern recognition, machine learning, and data mining have a great deal to offer the field of bioinformatics.
458p
tachieuhoa
28-01-2024
4
2
Download
-
Part 1 book "PCR mutation detection protocols" includes content: Conformation sensitive capillary electrophoresis, conformation sensitive gel electrophoresis, denaturing HPLC for mutation screening, in situ detection of human papillomavirus DNA after PCR-Amplification,.... and other contents.
153p
oursky06
17-10-2023
1
1
Download
-
Part 2 book "PCR mutation detection protocols" includes content: Mutation surveyor - software for DNA sequence analysis, non invasive prenatal diagnosis, phylogenetic microarrays for cultivation independent identification and metabolic characterization of microorganisms in complex samples,....and other contents.
153p
oursky06
17-10-2023
2
1
Download
-
Part 1 book "PCR Protocols" includes content: Long range PCR with a DNA polymerase fusion, isolation of genomic insertion sites of proviruses using splinkerette PCR based procedures, lariat dependent nested PCR for flanking sequence determination, a global single-Cell cDNA amplification method for quantitative microarray analysis,...and other contents.
171p
oursky06
17-10-2023
5
1
Download
-
We present a set of statistical methods for the analysis of DNA methylation microarray data, which account for tumor purity. These methods are an extension of our previously developed method for purity estimation; Our updated method is flexible, efficient, and does not require data from reference samples or matched normal controls.
14p
vialfrednobel
29-01-2022
4
0
Download
-
Changes in the quantity of genetic material, known as somatic copy number alterations (CNAs), can drive tumorigenesis. Many methods exist for assessing CNAs using microarrays, but considerable technical issues limit current CNA calling based upon DNA sequencing. We present SynthEx, a novel tool for detecting CNAs from whole exome and genome sequencing.
14p
vialfrednobel
29-01-2022
19
1
Download
-
In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements. Illumina have now released the MethylationEPIC (EPIC) BeadChip, with new content specifically designed to target these regions.
17p
viaristotle
29-01-2022
5
0
Download
-
Illumina DNA methylation microarrays enable epigenome-wide analysis vastly used for the discovery of novel DNA methylation variation in health and disease. However, the microarrays’ probe design cannot fully consider the vast human genetic diversity, leading to genetic artifacts.
29p
viarchimedes
26-01-2022
10
0
Download
-
Metastasis is the primary cause of cancer mortality accounting for 90% of cancer deaths. Our understanding of the molecular mechanisms driving metastasis is rudimentary. We perform whole exome sequencing (WES), RNA sequencing, methylation microarray, and immunohistochemistry (IHC) on 8 pairs of non-small cell lung cancer (NSCLC) primary tumors and matched distant metastases.
21p
viarchimedes
26-01-2022
12
0
Download
-
The recommended genomic DNA input requirements for whole genome single nucleotide polymorphism microarrays can limit the scope of molecular epidemiological studies. We performed a large-scale evaluation of whole genome amplified DNA as input into high-density, whole-genome Illumina® Infinium® SNP microarray.
10p
vibeauty
23-10-2021
9
1
Download
-
Microarray and DNA-sequencing based technologies continue to produce enormous amounts of data on gene expression. This data has great potential to illuminate our understanding of biology and medicine, but the data alone is of limited value without computational tools to allow human investigators to visualize and interpret it in the context of their problem of interest.
11p
vitzuyu2711
29-09-2021
10
1
Download
-
Varicella zoster virus (VZV) is a human pathogenic alphaherpesvirus harboring a relatively large DNA molecule. The VZV transcriptome has already been analyzed by microarray and short-read sequencing analyses.
20p
vitzuyu2711
29-09-2021
14
1
Download
-
Transcription factors (TFs) specifically bind to DNA sequences and control the expression of target genes. AoXlnR is a key TF involved in the expression of xylanolytic and cellulolytic enzymes in the filamentous fungi, Aspergillus oryzae. Genomic SELEX-Seq (gSELEX-Seq) can reveal the in vitro binding sites of a TF in a genome.
10p
viseulgi2711
31-08-2021
12
1
Download
-
Phương pháp phát hiện đồng thời các đột biến gen α và β thalassemia là cần thiết trong các chương trình ngăn ngừa và kiểm soát bệnh thalassemia. Mục đích chính của nghiên cứu là để đánh giá hiệu quả của DNA microarray này trong chẩn đoán các đột biến α và β thalassemia phổ biến tại Việt Nam.
8p
vikarina2711
24-08-2021
23
1
Download
-
Candida albicans is an opportunistic pathogen which is responsible for widespread nosocomial infections. It encompasses a fungus specific serine/threonine protein phosphatase gene, CaPPZ1 that is involved in cation transport, cell wall integrity, oxidative stress response, morphological transition, and virulence according to the phenotypes of the cappz1 deletion mutant.
17p
viansan2711
30-07-2021
5
1
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)