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DNA oligonucleotide design
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Part 1 book "PCR mutation detection protocols" includes content: Conformation sensitive capillary electrophoresis, conformation sensitive gel electrophoresis, denaturing HPLC for mutation screening, in situ detection of human papillomavirus DNA after PCR-Amplification,.... and other contents.
153p
oursky06
17-10-2023
1
1
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DNA microarrays have become ubiquitous in biological and medical research. The most difficult problem that needs to be solved is the design of DNA oligonucleotides that (i) are highly specific, that is, bind only to the intended target, (ii) cover the highest possible number of genes, that is, all genes that allow such unique regions, and (iii) are computed fast. None of the existing programs meet all these criteria.
8p
viwyoming2711
16-12-2020
14
1
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A clear difference in the enthalpy changes derived from spectroscopic and calorimetric measurements has recently been shown. The exact interpretation of this deviation varied from study to study, but it was generally attributed to the non-two-state transition and heat capacity change. Although the temperature-dependent thermodynamics of the duplex formation was often implied, systemic and extensive studies have been lacking in universally assigning the appropriate thermodynamic parameter sets.
10p
system191
01-06-2013
34
3
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Special oligonucleotides for targeted gene correction have attracted increasing attention recently, one of which is the chimericRNAÆDNAoligonucleotide (RDO) system. RDOs for targeted gene correction were first designed in 1996, and are typically 68 nucleotides in length including continuous RNA andDNA sequences (RNA is 2¢-O-methyl-modified).
6p
tumor12
22-04-2013
31
1
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