DNA repair genes
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Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leading to genome instability and high risk of diseases, in particular, cancer.
17p vishanshan 27-06-2024 2 1 Download
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The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably BRCA2, PALB2, ATM and BRCA1. Therefore, we hypothesized that additional shared genetic etiologies might be uncovered by studying families presenting with both breast and pancreatic cancer.
9p vikoch 27-06-2024 2 1 Download
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Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.
187p tracanhphuonghoa1007 22-04-2024 3 1 Download
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The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered.
3p vibransone 28-03-2024 5 2 Download
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Homologous recombination (HR) is the primary pathway for repairing double-strand DNA breaks implicating in the development of cancer. RNAi-based knockdowns of BRCA1 and RAD51 in this pathway have been performed to investigate the resulting transcriptomic profiles.
15p vioraclene 31-03-2024 3 2 Download
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Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or which modulate the tumour microenvironment or host immune system play significant roles in determining whether genetic mutations culminate in BCC development.
12p vibransone 28-03-2024 3 2 Download
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Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.
26p vibransone 28-03-2024 2 2 Download
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Part 1 book "Essential cell biology" includes content: Cells - The fundamental units of life, chemical components of cells energy, catalysis and biosynthesis, protein structure and function, DNA and chromosomes, DNA replication and repair, from DNA to protein - How cells read the genome, control of gene expression, how genes and genomes evolve, analyzing the structure and function of genes.
398p muasambanhan08 01-03-2024 2 1 Download
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Part 1 book "Textbook of biochemistry - With clinical correlations" includes content: Eukaryotic cell structure; DNA and RNA - Composition and structure; DNA and RNA - Composition and structure; DNA replication, recombination, and repair; RNA - Transcription and RNA processing; protein synthesis - Translation and posnranslational modifications; recombinant DNA and biotechnology; regulation of gene expression.
368p muasambanhan04 07-01-2024 3 1 Download
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Part 1 book "Cancer biology" includes content: What is cancer; natural history - the life of a cancer; pathology - Defining a neoplasm; epidemiology - identifying causes for human cancers; oncogenes, tumour suppressor genes and viruses, chemical and radiation carcinogenesis; mutations, DNA repair and genetic instability.
146p muasambanhan02 25-12-2023 4 3 Download
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Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer.
10p vileonardodavinci 23-12-2023 7 2 Download
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Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replication, DNA damage repair, genomic integrity, and telomere stability.
7p vileonardodavinci 23-12-2023 3 2 Download
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Lung squamous cell carcinoma (LUSC) is prone to metastasis and likely to develop resistance to chemotherapeutic drugs. DNA repair has been reported to be involved in the progression and chemoresistance of LUSC. However, the relationship between LUSC patient prognosis and DNA damage repair genes is still unclear.
14p vialfrednobel 23-12-2023 7 4 Download
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Part 1 book "Alberts - Essential cell biology" includes content: Cells - the fundamental units of life; chemical components of cells; energy, catalysis, and biosynthesis; protein structure and function; DNA and chromosomes; DNA replication, repair, and recombination; from DNA to protein - how cells read the genome; control of gene expression; how genes and genomes evolve; modern recombinant DNA technology.
383p muasambanhan01 13-12-2023 4 2 Download
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Genomic alterations, including loss of function in chromosome band 11q22-23, are frequently observed in neuroblastoma, which is the most common extracranial childhood tumour. In neuroblastoma, ATM, a DNA damage response-associated gene located on 11q22-23, has been linked to tumorigenicity.
13p vischultz 20-10-2023 2 1 Download
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Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC).BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein.
13p vischultz 20-10-2023 1 1 Download
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Part 3 book "Biochemistry" includes content: The biosynthesis of amino acids, nucleotide biosynthesis, the biosynthesis of membrane lipids and steroids, the integration of metabolism, DNA replication, repair, and recombination, RNA synthesis and processing, protein synthesis, the control of gene expression in prokaryotes, the control of gene expression in eukaryotes.
336p oursky07 24-10-2023 9 3 Download
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This study aimed to identify patients with upper urinary tract urothelial carcinoma (UTUC) having potential Lynch syndrome (pLS) by immunohistochemistry (IHC) of DNA mismatch repair gene-related proteins (MMRPs) and Amsterdam criteria II and explore their clinical characteristics.
9p visharma 20-10-2023 4 2 Download
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The association involving mismatch repair (MMR) genes, molecular subtype and specific immune cell group in tumor microenvironment has been focused by more recent studies. Its prognosis value in lung adenocarcinoma (LUAD) neoadjuvant chemotherapy remains elusive.
12p visharma 20-10-2023 3 2 Download
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Endometrial carcinoma (EC) is one of the most commonly diagnosed gynecologic malignancy in China. However, the genetic profile of Chinese EC patients has not been well established yet. In current study, 158 Chinese EC patients were subjected to next-generation sequencing assay (74 took testing of EC-related 20-genes panel, and 84 took the expanded panel).
15p vioracle 29-09-2023 5 2 Download