DNA sequencing and TLR4

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Association between genotypes of TLR4 gene RS2149356 polymorphism and serum level of IL-6 in Vietnamese patients with gout

Gout is an inflammatory type of arthritis caused by the deposition of crystals of monosodium urate monohydrate (MSU) in the joints. The arthritis is mediated by the release of proinflammatory cytokines including IL-1β, TNF-α and IL-6 by leukocytes including macrophages.

6p vicaptainmarvel 21-04-2023 6 2 Download

Expression and significance of HMGB1, TLR4 and NF-κB p65 in human epidermal tumors

High mobility group protein box 1 (HMGB1) is a DNA binding protein located in nucleus. It is released into extracellular fluid where it acts as a novel proinflammatory cytokine which interacts with Toll like receptor 4 (TLR4) to activate nuclear factor-κB (NF-κB). This sequence of events is involved in tumor growth and progression. However, the effects of HMGB1, TLR4 and NF-κB on epidermal tumors remain unclear.

10p vijennie2711 29-09-2020 20 0 Download