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Dose tolerance
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Life expectancy of patients with metastatic castration-resistant prostate cancer (mCRPC) is still limited despite several systemic treatments. Within five years after diagnosis of primary prostate cancer, 10–20% of the patients have mCRPC and curation is not an option.
8p
vikoch
27-06-2024
1
1
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Heart failure (HF) with reduced ejection fraction (HFrEF) is a complex clinical syndrome associated with high mortality, long hospital length of stay, high readmission rates, reduced exercise tolerance, and decreased quality of life, as well as requiring significant resources to support treatment and care.
7p
vicwell
06-03-2024
14
1
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Conquering acquired resistance to osimertinib remains a major challenge in treating patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Thus, we aimed to determine the safety and efcacy of combination treatment with osimertinib and afatinib for patients with acquired resistance to osimertinib.
9p
vileonardodavinci
23-12-2023
7
2
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Previous randomized studies have shown a survival benefit of using regorafenib but a high rate of adverse events in unresectable colorectal cancer patients. To reduce these adverse events and improve the tolerability, we examined the appropriate dose of regorafenib based on body weight.
9p
vileonardodavinci
23-12-2023
3
2
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The objective of this study was to investigate the tolerance of capecitabine, an example of oral chemotherapy, among older adults with cancer and explore factors associated with capecitabine-related side effects and treatment changes, to enhance supportive care.
14p
vialfrednobel
23-12-2023
5
4
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Part 2 book "A guide to sample size for animal-based studies" includes content: Prediction intervals, tolerance intervals, reference intervals, sample size and hypothesis testing, a bestiary of effect sizes, comparing two groups - continuous outcomes, comparing two groups - proportions, time‐to‐event (survival) data; comparing multiple factors; hierarchical or nested data; ordinal data; dose‐response studies.
154p
muasambanhan01
11-12-2023
7
2
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The Maillard reaction products (MRPs) were synthesized during the gamma irradiation of mixtures of chitosan (CT) and/or oligochitosan (OC) with glucosamine (GA) at the dose of 25 kGy and investigated their some characteristics. The formations of MRPs were determined by UV-vis spectromectric analyses at the wavelength of 284 nm and 420 nm.
8p
vicedric
08-02-2023
6
4
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The study "Biochar mitigates salt stress by regulating nutrient uptake and antioxidant activity, alleviating the oxidative stress and abscisic acid content in cabbage seedlings" was conducted as factorial completely randomized design with two factors; salinity levels (0 and 150 mM NaCl) and biochar doses (weighed at the rate of 0%, 2.5%, and 5% by soil weight). Growth parameters such as stem diameter, leaf area, shoot fresh weight, root fresh weight, shoot dry weight, and root dry weight of cabbage seedlings treated with 150 mM NaCl were lower than the control.
10p
lyhuyenthu
31-01-2023
6
2
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To investigate the maximum tolerated dose (MTD) of apatinib delivered during and after intensitymodulated radiotherapy (IMRT) for unresectable hepatocellular carcinoma (HCC).
7p
vikolindagrabar
27-07-2022
4
1
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Acquired resistance to approved tyrosine kinase inhibitors limits their clinical use in patients with gastrointestinal stromal tumor (GIST). This study investigated the safety, tolerability and efficacy of alpelisib, a phosphatidylinositol 3-kinase inhibitor, used in combination with imatinib in patients with advanced GIST who had failed prior therapy with both imatinib and sunitinib.
8p
vikolindagrabar
27-07-2022
5
1
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Radiation-induced brainstem necrosis (RIBN) is a late life-threatening complication that can appear after treatment in patients with nasopharyngeal carcinoma (NPC). However, the relationship between RIBN and radiation dose is not still well-defined.
8p
vipriyankagandhi
27-07-2022
2
1
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To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection. A premedication with oral paracetamol can dose-dependently reduce pain at propofol intravenous injection. To avoid this common uncomfortable concern for the patients, this well-tolerated, available and cheap treatment appears as an option to be implemented in the current practice.
7p
vizhangzhidong
29-12-2021
12
0
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Thirty-five of them, who presented with systolic HF and were not eligible for HTx due to RFPH, were included in the study (31 men aged 55.1 ± 7.4 years). In all the patients sildenafil was introduced and uptitrated to a maximal tolerated dose in addition to optimal medical therapy. Patients were assessed at 3–6 months intervals.
6p
lazzaro
30-12-2021
7
0
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The overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods assume that the incidences of efficacy and toxicity always increase as dose is increased.
18p
vimahuateng
26-11-2021
11
1
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This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with relapsed / refractory lymphoma or advanced solid organ cancers and to assess HR23B protein expression by immunohistochemistry as a biomarker of HDAC inhibitor sensitivity.
10p
vimahuateng
26-11-2021
6
0
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Classical phase 1 dose-finding designs based on a single toxicity endpoint to assess the maximum tolerated dose were initially developed in the context of cytotoxic drugs. With the emergence of molecular targeted agents and immunotherapies, the concept of optimal biological dose (OBD) was subsequently introduced to account for efficacy in addition to toxicity.
10p
vianrose2711
27-04-2021
13
1
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The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initial estimate of the dose-toxicity relationship (prior skeleton) is required, and there is limited guidance on how to select this.
10p
vichaeng2711
29-04-2021
24
1
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Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains unclear. Current guidelines recommend treating beyond 4 cycles -up to 6-, in patients that respond to and tolerate systemic treatment.
8p
vimichigan2711
26-03-2021
12
2
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Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability and pharmacokinetics of abediterol in patients with moderate to severe COPD.
13p
vimaine2711
26-03-2021
10
2
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Batefenterol (BAT) is a bi-functional molecule with both muscarinic antagonist and β2-adrenoceptor agonist pharmacology. This Phase II, randomized, placebo-controlled, double-blind study evaluated the safety and tolerability of BAT 300 μg with fluticasone furoate (FF) 100 μg administered via the ELLIPTA inhaler (BAT/FF 300/ 100).
10p
vimaine2711
26-03-2021
10
2
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