Drug combination

In this study, we explore the potential of graph neural networks (GNNs), in combination with transfer learning, for the prediction of molecular solubility, a crucial property in drug discovery and materials science. Our approach begins with the development of a GNN-based model to predict the dipole moment of molecules.

8p viwalton 02-07-2024 1 0   Download

Glioblastoma is the most common and most aggressive malignant primary brain tumor in adults. Glioblastoma cells synthesize and secrete large quantities of the excitatory neurotransmitter glutamate, driving epilepsy, neuronal death, tumor growth and invasion.

7p vishanshan 27-06-2024 2 1   Download

Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.

16p vishanshan 27-06-2024 1 1   Download

For chronic pain after thoracic surgery, optimal timing of its diagnosis and effective treatment remains unresolved, although several treatment options are currently available. We examined the efficacy and safety of mirogabalin, in combination with conventional pain therapy (nonsteroidal anti-infammatory drugs and/or acetaminophen), for treating peripheral neuropathic pain (NeP) after thoracic surgery.

15p vishanshan 27-06-2024 1 1   Download

The present research was designated to investigate the potential of ZnONP nanocomposites as a cancer chemotherapeutic-based drug delivery system and to assess the anti-tumor and anti-inflammatory effectiveness of ZnONP nanocomposites combination with systemic chemotherapeutic drugs doxorubicin (DOX) and folic acid (FA) in Ehrlich ascites carcinoma (EAC) tumor cell line both in vitro and in vivo.

16p vishanshan 27-06-2024 1 1   Download

The combination of antifungal drugs for the treatment of dermatophytosis, including oral itraconazole and topical terbinafine, has been shown to be more effective than monotherapy. To describe the clinical characteristics and evaluate the results of patients with dermatophytosis treated with the combination of oral itraconazole and topical terbinafine at Can Tho Hospital of Dermato-Venereology in 2023.

7p vikoch 27-06-2024 1 1   Download

The development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often treated together as a combinatorial therapy. In particular, synergistic drug combinations, which kill cancer cells at a lower concentration, guarantee a better prognosis and fewer side effects in cancer patients.

16p vikoch 27-06-2024 2 1   Download

Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to assess the outcome of temozolomide, alone or in combination with other anticancer medications in patients with advanced pNET.

15p vikoch 27-06-2024 1 1   Download

While immunotherapy combined with chemotherapy (Chemo-IO) is generally recognized for providing superior outcomes compared to monotherapy (mono-IO), it is associated with a higher incidence of treatmentrelated adverse events (TRAEs), which may lead to treatment discontinuation. In this study, we compared the rates of treatment discontinuation between mono-IO and Chemo-IO as first-line treatments for various solid tumors.

12p vikoch 27-06-2024 2 1   Download

This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.

509p vimeyers 29-05-2024 5 2   Download

Terpenoid indole alkaloids (TIAs) vincristine and vinblastine are two essential anticancer drugs used in cancer treatments. These compounds are naturally available only in Catharanthus roseus in low accumulation, leading to efforts to upregulate TIAs substances through other expression organisms. The combination of vindoline and catharanthine into α-3∼,4∼- anhydrovinblastine (AVLB) is an important step for the biosynthesis of vinca alkaloids, which serves as a precursor to vinblastine and vincristine.

10p dianmotminh02 03-05-2024 4 2   Download

The aim of the study was to explore how the logistics, micro, market and macro coordination dimensions affect the availability of artemisinin-based combination therapies (ACTs) in general hospitals in Uganda. Following a qualitative approach, a multiple case study strategy was used. Specifically, four focus group discussions, each consisting of 8 respondents were conducted from four purposively selected hospitals.

18p longtimenosee10 26-04-2024 2 1   Download

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Low back pain in lumbar spondylosis remains one of the most prevalent conditions, imposing a significant socio-economical burden. Objectives: To compare the effectiveness of low back pain treatment between NSAIDS and electro-acupuncture combined with infrared light (TCM) in patients with lumbar spondylosis.

5p vioraclene 31-03-2024 3 1   Download

Recent advances in genomic sequencing and omics-based capabilities are uncovering tremendous therapeutic opportunities and rapidly transforming the field of cancer medicine. Molecularly targeted agents aim to exploit key tumor-specific vulnerabilities such as oncogenic or non-oncogenic addiction and synthetic lethality.

14p vioraclene 31-03-2024 2 2   Download

Ebook "Fluorine in heterocyclic chemistry - Volume 2: 6-membered heterocycles" combines data connected with the chemistry of fluorine containing 6-membered heterocycles. The main part of modern marketed drugs are heterocyclic compounds of various types. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture.

769p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Prokaryotic systems biology (Advances in experimental medicine and biology, Volume 883)" focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species.

326p duongthandue0501 28-02-2024 3 1   Download

Ebook "Artemisia annua - Pharmacology and biotechnology" is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs.

288p manmanthanhla0201 26-02-2024 7 1   Download

Ebook "Fragment-based drug discovery and X-ray crystallography (Topics in current chemistry, Volume 317)" bring together chapters by a number of practitioners in the field, drawn from both the pharmaceutical industry and academia. Our aim has been to highlight the important roles that X-ray crystallography plays in the fragmentapproach: as a sensitive technique for primary screening, its use in combination with other biophysical techniques to allow robust hit validation, and its importance in providing structural information to guide progression from hit to clinical candidate.

235p manmanthanhla0201 26-02-2024 5 1   Download

Immune checkpoint inhibitors are new immunotherapy drugs globally used for many malignancies, including renal cell carcinoma. Myocarditis as an immune-related adverse event is rare but highly fatal, suggesting that its frequency may be higher than reported. This paper describes a case of myocarditis that developed asymptomatically following ipilimumab and nivolumab combination therapy for renal cell carcinoma.

8p vilazada 31-01-2024 5 2   Download