Drug disposition

A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications.

235p vimeyers 29-05-2024 7 2   Download

Part 1 book "Concepts and applications in veterinary toxicology - an interactive guide" includes content: General principles of toxicology; disposition and fate of toxicants; mechanism of toxicity; toxic effects of pesticides and agrochemicals; toxic effects of metals and micronutrients; toxicologic hazards of solvents, gases, vapors, and other chemicals; toxicities from human drugs

178p muasambanhan04 11-01-2024 3 1   Download

Part 1 book "Equine anesthesia" includes content: Acknowledgments, history of equine anesthesia, the respiratory system, the cardiovascular system, stress associated with anesthesia and surgery, physical restraint, preoperative evaluation - general considerations, venous and arterial catheterization and fluid therapy, monitoring anesthesia, principles of drug disposition and drug interaction in horses,.... and other contents.

282p oursky09 12-11-2023 5 3   Download

Part 1 book "The physiological basis of veterinary clinical pharmacology" includes content: The pharmacokinetic basis of species variations in drug disposition, the concept of bioavailability and applications to veterinary dosage forms, interpretation of changes in drug disposition and interspecies scaling.

149p oursky05 20-09-2023 2 1   Download

Part 2 book "The physiological basis of veterinary clinical pharmacology" includes content: Some aspects of dosage, clinical selectivity and stereoisomerism, drug permeation through the skin and topical preparations, antimicrobial disposition, selection, administration and dosage, the bioavailability and disposition of antimicrobial agents in neonatal animals.

149p oursky05 20-09-2023 5 2   Download

Part 1 book "Handbook of veterinary pharmacology" includes content: Principles of drug absorption, drug disposition, and drug action; principles of drug absorption, drug disposition, and drug action; autacoids and their pharmacological modulators autacoids and their pharmacological modulators, behavior modifying drugs, anesthetics, nonsteroidal anti inflammatory drugs, drugs acting on the cardiovascular system, diuretics.

234p oursky05 20-09-2023 10 2   Download

Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made in the past 50 years. The field of pharmacogenomics seeks to elucidate inherited differences in drug disposition and effects.

9p vinarcissa 21-03-2023 2 1   Download

Varying the rate of continuous intravenous infusions of 5-fluorouracil (5FU) chemotherapy over a 24-hour period has been reported to improve patient outcomes. It has been hypothesized that circadian variation in drug disposition is a contributing factor. We analyzed 5-FU concentrations during a 24-hour continuous 5-FU infusion

8p vialabama2711 21-09-2020 12 1   Download

Cutaneous adverse reactions (CARs) from antiepileptic drugs (AEDs) are common, ranging from mild to life-threatening, including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The identification of subjects carrying the HLA-B*15:02, an inherited allelic variant of the HLAB gene, and the avoidance of carbamazepine (CBZ) therapy in these subjects are strongly associated with a decrease in the incidence of carbamazepine-induced SJS/TEN. In spite of the strong genetic associations, the initiation of hypersensitivity for AEDs is still not very well characterized.

10p caothientrangnguyen 09-05-2020 10 1   Download

Bio-enhancers such as piperine, curcumine, ginger and cow urine distillate are being seen as important adjuvant drugs to combat antimicrobial resistance and to increase efficiency of antimicrobial agents. Cow urine distillate is one of the important bio-enhancer easily available with farmer. The disposition kinetics was aimed to assess the pharmacokinetic alteration in profile of moxifloxacin, a third generation fluoroquinolone anti-microbial agent. Moxifloxacin was administered at the dose rate of 5 mg.

9p chauchaungayxua3 07-02-2020 12 1   Download

Marbofloxacin is a third generation quinolone developed exclusively for veterinary use. The disposition kinetic profile of marbofloxacin was generated after a single intravenous bolus injection in male Sahiwal calves (n = 5) at the dose level of 2 mg.kg-1 body weight. Marbofloxacin concentrations in plasma were determined by microbiological assay using Escherichia coli MTCC 443 as the test organism. The plasma concentration–time profile following intravenous administration was best described by a two-compartment open model. The plasma drug concentration ≥ 0.12 μg.ml-1 was detected at 24 h.

8p chauchaungayxua3 07-02-2020 13 1   Download

Due to this very detrimental environmental hazard experienced during this period by Zanzibar islands, with very sensitive and fragile ecosystem the Ministry of Health and Social Welfare in collaboration with WHO decided to develop these official and very comprehensive guidelines based on the National Drug Policy, WHO guidelines and the Zanzibar Food, Drugs and Cosmetics Act No 2/2006. Therefore these guidelines give appropriate measures of safe disposal to minimize the risks that could happen due to pharmaceutical waste. ...

25p dacotaikhoan 25-04-2013 88 6   Download

Navigant  reconstructed  the  historical  costs  of  the  WTC  program  using  the  chronology  of  periodic  Port  Authority  presentations  by  prior  Executive  Directors  and  management  to  the  Board  of Commissioners,  project  cost  reports  current  as  of October  2011,  related  documents,  and  the  findings  of  interviews  to  provide  the  Special  Committee  with  the  analysis  of  past  spending  at  the WTC  site.  Furthermore, Navigant  preliminarily  and  independently  analyzed  the Port Authority’s estimated cost to complete for its reasonableness.   ...

200p tay_thi_le 19-02-2013 45 5   Download

In a certain sense, the field of drug metabolism (DM) is standing still. More specifically, the basic experiment of drug metabolism (i.e., administering a new drug to an animal or human and determining the structures, amounts, and disposition of the metabolites) has changed very little over a period of decades. Remarkably, the experimental design and resulting data set from a typical absorption, distribution, metabolism, and excretion (ADME) study conducted today would be instantly recognized and understood by DM scientists from 50 years ago.

785p thienbinh1311 13-12-2012 60 6   Download

Drug Interactions Not Mediated by Changes in Drug Disposition Drugs may act on separate components of a common process to generate effects greater than either has alone. Antithrombotic therapy with combinations of antiplatelet agents (glycoprotein IIb/IIIa inhibitors, aspirin, clopidogrel) and anticoagulants (warfarin, heparins) are often used in the treatment of vascular disease, although such combinations carry an increased risk of bleeding.

5p tubreakdance 26-11-2010 82 4   Download

Multiple Variants Modulating Drug Effects As this discussion makes clear, for each drug with a defined mechanism of action and disposition pathways, a set of "candidate genes," in which polymorphisms may mediate variable clinical responses, can be identified. Indeed, polymorphisms in multiple genes have been associated with variability in the effect of a single drug. CYP2C9 loss-of-function variants are associated with a requirement for lower maintenance doses of the vitamin K antagonist anticoagulant warfarin. In rarer (...

8p tubreakdance 26-11-2010 92 4   Download

Principles of Pharmacokinetics The processes of absorption, distribution, metabolism, and excretion— collectively termed drug disposition—determine the concentration of drug delivered to target effector molecules. Absorption Bioavailability When a drug is administered orally, subcutaneously, intramuscularly, rectally, sublingually, or directly into desired sites of action, the amount of drug actually entering the systemic circulation may be less than with the intravenous route (Fig. 5-2A ).

8p tubreakdance 26-11-2010 107 6   Download