Drug drug interaction

The development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often treated together as a combinatorial therapy. In particular, synergistic drug combinations, which kill cancer cells at a lower concentration, guarantee a better prognosis and fewer side effects in cancer patients.

16p vikoch 27-06-2024 2 1   Download

Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.

14p vikoch 27-06-2024 1 1   Download

Part 2 book "Cardiac drug therapy" includes content: Beta blockers: Angina, myocardial infarction, heart failure, heart failure controversies, arrhythmias, cardiac arrest, infective endocarditis, dyslipidemias, endocrine heart diseases, antiplatelet agents, anticoagulants, factor xa inhibitors, and thrombin inhibitors cardiac drugs during pregnancy and lactation drug interactions, hallmark clinical trials.

470p zizaybay1101 30-04-2024 4 2   Download

Part 1 book "Clinical pharmacy and therapeutics" includes content: Clinical pharmacy process, practical pharmacokinetics, drug interactions, adverse drug reactions, laboratory data, parenteral nutrition, liver disease, cute kidney injury, chronic kidney disease and end-stage renal disease, coronary heart disease.

493p zizaybay1101 30-04-2024 3 2   Download

Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.

323p ladongphongthanh1008 22-04-2024 3 3   Download

Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

325p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Ultrasonic production of nano-emulsions for bioactive delivery in drug and food applications" provides an overview of ultrasonic emulsification and an update on recent advances in developing stable emulsions for the creation of novel drugs and functional foods, with a focus on bioactive delivery in these products. The interaction of ultrasound with the hydrocolloids and biopolymers that are often used to stabilize emulsions can offer advantages such as improved stability or greater control of formed droplet size distributions.

46p tracanhphuonghoa1007 22-04-2024 4 3   Download

Ebook "Targeting protein-protein interactions by small molecules" comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design.

332p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.

327p tracanhphuonghoa1007 22-04-2024 3 3   Download

Ebook "Water stress in biological, chemical, pharmaceutical and food systems" will be particularly useful to professionals and students working on water science mainly dealing with food, chemical, biological, and pharmaceutical systems. It has a total of 61 chapters divided in four sections: (1) Advances in the assessment of water state in food, biological, and pharmaceutical systems; (2) Applied research on thermodynamics and physiochemical concepts on water in pharmaceutical and food products;...

666p tracanhphuonghoa1007 22-04-2024 3 3   Download

Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military Hospital 7.

5p viohoyo 02-04-2024 4 1   Download

A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.

15p vibransone 28-03-2024 3 2   Download

Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.

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Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient populations and improve drug efficacy.

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Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.

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Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

248p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Disruption of protein–protein interfaces: In search of new inhibitors" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs.

166p coduathanh1122 27-03-2024 2 1   Download

Ebook "Prokaryotic systems biology (Advances in experimental medicine and biology, Volume 883)" focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species.

326p duongthandue0501 28-02-2024 3 1   Download

Ebook "Medical geochemistry: Geological materials and health" includes a collection of chapters illustrating the application of geochemical methods to investigate the interactions between geological materials and fluids with humans. Examples include the incorporation and human health effects of inhaling lithogenic materials, the reactivity of biological fluids with geological materials, and the impact on nascent biomineral formation.

199p duongthandue0501 28-02-2024 2 1   Download