Drug exposure

YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.

18p vishanshan 27-06-2024 1 1   Download

Part 2 book "Physical assessment of the newborn - A comprehensive approach to the art of physical examination" includes content: Abdominal assessment; genitourinary assessment; musculoskeletal system assessment; neurologic assessment; behavioral assessment; assessment of the dysmorphic infant; pain assessment in the newborn; assessment of the newborn with antenatal exposure to drugs.

195p dianmotminh03 17-06-2024 1 0   Download

The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed.

236p vimeyers 29-05-2024 5 2   Download

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.

607p vimeyers 29-05-2024 2 2   Download

Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.

15p vibransone 28-03-2024 4 2   Download

Oxaliplatin-based chemotherapy represents a standard of care in the treatment of metastatic colorectal cancer. We report a rare case of fulminant oxaliplatin-induced thrombotic microangiopathy, clinically suggestive of hemolytic–uremic syndrome, occurring in a female patient with a prolonged history of exposure to oxaliplatin for the treatment of metastatic colon cancer.

6p vitiki 30-01-2024 6 2   Download

Part 2 book "Dr. Kellon's guide to first aid for horses" includes content: Collapse; disorders of balance, coordination, personality; trauma to the head and neck; eyes; frostbite and exposure; lightning and electric shock; disorders of urine urination; reproductive organs; foaling; newborn emergencies; some common drug reactions; reference; procedures; emergency splinting techniques for stabilizing equine fractures; trailer accidents and trapped horses.

278p muasambanhan04 14-01-2024 7 3   Download

Ebook "Neural cell biology" delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text　reviews and　discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development.

348p lucchinguyen 28-12-2023 7 2   Download

Part 1 book "Applied equine nutrition and training" includes content: How to feed sport horses with roughage only; medicinal plants for animals – a current therapeutic option with long tradition; equine immunology and phytogenic drugs - possibilities and limitations; mycotoxicoses in horses - toxins, occurrence in feed, and the search for markers of exposure; the whole horse approach to equine physical rehabilitation - the biomechanical view,... and other contents.

72p oursky10 07-12-2023 5 3   Download

To increase the chances of finding efficacious anticancer drugs, improve development times and reduce costs, it is of interest to rank test compounds based on their potential for human use as early as possible in the drug development process. In this paper, we present a method for ranking radiosensitizers using preclinical data.

19p visharma 20-10-2023 4 2   Download

Part 1 book "Veterinary medicines in the environment" includes content: Assessing the aquatic hazards of veterinary medicines, exposure assessment of veterinary medicines in terrestrial systems, assessing the effects of veterinary medicines on the terrestrial environment, workshop conclusions and recommendations.

103p oursky05 20-09-2023 2 2   Download

Part 1 book "Veterinary medicines in the environment" includes content: Introduction, uses and inputs of veterinary medicines in the environment, environmental risk assessment and management of veterinary medicines, exposure assessment of veterinary medicines in aquatic systems.

123p oursky05 20-09-2023 3 1   Download

Drug-induced lupus erythematosus is a rare condition associated with the exposure to certain drugs capable of triggering an autoimmune disease similar to systemic lupus erythematosus. Although there are no available diagnostic criteria, clinical and serological findings and its temporal association with the initiation of the suspected drug are important to establish the diagnosis.

3p viintuit 26-09-2023 4 0   Download

Henoch-Schonlein purpura (HSP) is known as a leukocytoclastic vasculitis of small vessels, resulting in skin, joint, gastrointestinal (GI) and renal involvement. It is the most common acute vasculitis in children but is relatively uncommon in adults. The pathogenesis of HSP remains unclear, but a wide variety of conditions such as bacterial or viral infections, vaccinations, drugs and other environmental exposures may be responsible for the onset.

6p viintuit 26-09-2023 4 0   Download

Part 1 book "Averys diseases of the newborn" includes content: Neonatal and perinatal epidemiology; biomedical informatics in neonatology; ethics, data, and policy in newborn intensive care; global neonatal health; development, function, and pathology of the placenta; abnormalities of fetal growth; nonimmune hydrops, maternal diabetes; maternal medical disorders of fetal significance; prenatal drug exposure,... and other contents.

566p oursky03 28-08-2023 2 1   Download

Part 1 of ebook "Clarke’s analytical forensic toxicology" presents the following content: introduction to forensic toxicology; pharmacokinetics and metabolism; drugs of abuse; other substances encountered in clinical and forensic toxicology; workplace drug testing; alternative specimens; postmortem toxicology; clinical toxicology, therapeutic drug monitoring, in utero exposure to drugs of abuse;...

323p dieptieuung 14-07-2023 6 1   Download

Acute interstitial nephritis (AIN) classically presents as acute kidney injury most often induced by offending drugs. Less frequently it is secondary to infections, autoimmune disorders, or idiopathic conditions. Development of drug-related AIN is not dose dependent and a recurrence can occur with re-exposure to the drug.

8p viwhitewolf 03-07-2023 4 2   Download

Observational studies analyzing multiple exposures simultaneously have been limited by difficulty distinguishing relevant results from chance associations due to poor specificity. Set-based methods have been successfully used in genomics to improve signal-to-noise ratio.

10p visteverogers 24-06-2023 3 2   Download

Evidence is scarce regarding the safety of long-term drug use, especially for drugs treating chronic diseases. To bridge this knowledge gap, this research investigated the differences in drug exposure between clinical trials and clinical practice.

5p vighostrider 25-05-2023 6 3   Download

Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by certain foods such as fava beans, drugs or infections.

9p vihagrid 30-01-2023 7 3   Download