Drug loading
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The present research was designated to investigate the potential of ZnONP nanocomposites as a cancer chemotherapeutic-based drug delivery system and to assess the anti-tumor and anti-inflammatory effectiveness of ZnONP nanocomposites combination with systemic chemotherapeutic drugs doxorubicin (DOX) and folic acid (FA) in Ehrlich ascites carcinoma (EAC) tumor cell line both in vitro and in vivo.
16p vishanshan 27-06-2024 2 1 Download
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Part 2 book "Recent advances in novel drug carrier systems" includes content: Nanocarrier systems for transdermal drug delivery; oral delivery of insulin - novel approaches; novel mucoadhesive polymers for nasal drug delivery; amphiphilic cyclodextrins, synthesis, utilities and application of molecular modeling in their design; processing and templating of bioactive loaded polymeric neural architectures - challenges and innovative strategies; novel drug delivery systems for modulation of gastrointestinal transit time,... and other contents.
260p muasambanhan09 16-03-2024 7 1 Download
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The study aimed to determine the smoking prevalence and explore the association between smoking and viral load among people living with HIV who are drug users (HIV+ PWID) in Vietnam. We used secondary data from a descriptive cross-sectional study of 280 HIV+ PWID in an open-label, non-inferiority trial from July 2015 to February 2018 at six HIV clinics in Northern Vietnam.
10p vilarry 12-03-2024 4 1 Download
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Mesoporous silica nanoparticles (MSNs) have been demonstrated as a promising candidate in drug delivery applications. With the ambition of enhancing their drug loading capacity and controlled release, in this innovative study, MSNs were tailored with polyamidoamine (PAMAM) dendrimers thereby exerting advantageous properties onto the surface of the nanoplatforms.
7p vimichaelfaraday 28-12-2023 5 3 Download
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In the present study, we report changes in ileal motility after gravity-stress with and without Sansho intake in male and female rats. Ileal movements were activated by topical Acetylcholine (Ach) application, and maximum amplitudes (MA) of the evoked contraction were compared.
4p viisac 23-09-2023 7 1 Download
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Natural polymer-based nanofibers with functions of loading and releasing bioactive cues or drugs have recently gained interest for biomedical applications. Nanotopography and large surface area to volume ratio of hydrophilic polymer fibers promote their use as carriers of hydrophilic drugs.
8p viberbers 09-08-2023 7 4 Download
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Polyphyllin I (PPI) is a naturally active steroidal saponin that has good therapeutic effects in various cancers, such as liver and lung cancers. However, owing to its non-selective distribution in various tissues, it is toxic and has side effects on normal human organs while taking effect.
12p viberbers 09-08-2023 3 2 Download
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In this investigation, a new nanocomposite as a nanocarrier based on functionalized graphene oxide was synthesized by reaction of tetraethylenepentamine and chlorosulfonic acid with functional groups on the surface of GO. The synthesized nanocomposite was characterized by FT-IR, XRD TGA, FE-SEM, EDAX, TEM, and AFM analysis. To explore the potential of nanocomposites in drug delivery, the loading and releases of quercetin as an anticancer drug were investigated.
12p lyhuyenthu 31-01-2023 3 2 Download
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Quercetin, a multifunctional therapeutic agent, is used in various types of cancer. However, its therapeutic effect is limited by virtue of poorly aqueous solubility and instability in the physiological medium. To overcome these limitations, we aimed (i) to design quercetin loaded liposomes with unlinked-PEG4000 with regard to not only surface modification but also solubility enhancement, and (ii) to investigate the antineoplastic effects on HeLa cells.
13p lyhuyenthu 31-01-2023 2 2 Download
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The primary aim of this article was to improve the solubility and bioavailability of the drugs nifedipine, niclosamide, and furosemide due to their poor solubility and dissolution rate. Therefore, these drugs require improvement in solubility and dissolution rate in formulation development, especially in solid dosage forms such as hydrogels and capsules. Hydrogel structures were synthesized by using a biocompatible, nontoxic, and protective pure 2-hydroxy ethyl methacrylate (HEMA) monomer.
13p lyhuyenthu 31-01-2023 7 2 Download
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The species belonging to the Lamiaceae family have been useful tools for many years as a folk remedy. In the present study, a microemulsion system was developed with extract of Scutellaria salviifolia Benth (endemic), Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm (endemic), and Ziziphora clinopodioides Lam. Both and related microemulsion formulations were also investigated for their potential biological activities.
11p lyhuyenthu 31-01-2023 9 2 Download
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SEM and TEM were used to evaluate the surface morphology and microstructure of the fiber membrane. Ultraviolet spectrophotometry was used to detect drug release. A LIVE/DEAD Viability/Cytotoxicity Kit and fluorescence staining were used to detect cell morphology and activity. Alkaline phosphatase and calcium mineralization deposition were used to evaluate the osteoinductive activity of the scaffold. Dynamic mechanical analysis was used to determine the Young’s modulus, maximum load, and maximum elongation of the prepared scaffold.
12p lyhuyenthu 31-01-2023 6 2 Download
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Magnetic microgels with pH- and thermo-responsive properties were developed from the pectin maleate, N-isopropyl acrylamide, and Fe3O4 nanoparticles. The hybrid materials were characterized by infrared spectroscopy, scanning electron microscope coupled with X–ray energy dispersive spectroscopy, wide angle X–ray scattering, Zeta potential, and magnetization hysteresis measurements.
8p vihermione 06-01-2023 8 4 Download
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Oromucosal administration is an attractive non-invasive route. However, drug absorption is challenged by salivary flow and the mucosa being a significant permeability barrier. The aim of this study was to design and investigate a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with unique properties and based on polysaccharides combined as i) mucoadhesive chitosan-based nanofibers, ii) a peptide loaded hydroxypropyl methylcellulose foam, and iii) a saliva-repelling backing film based on ethylcellulose.
10p vihermione 30-12-2022 42 2 Download
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In this study, the ability of different beta-cyclodextrins to facilitate homogeneous dispersion of triamcinolone acetonide (TA) into chitosan membranes is assessed. Drug loading was assessed through atomic force microscopy (AFM), scanning electron microscopy (MEV-FEG), and X-ray diffraction analyses.
11p viginny 30-12-2022 6 3 Download
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Xylan extracted from corn cobs was used to produce mesalamine-loaded xylan microparticles (XMP5-ASA) by cross-linking polymerization using a non-hazardous cross-linking agent. The microparticles were characterized by thermal analysis (DSC/TG), X-ray diffraction (XRD), Infrared spectroscopy (FTIR-ATR) and scanning electron microscopy (SEM).
9p viginny 30-12-2022 8 2 Download
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Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen threedimensional network of synthetic polymers or natural macromolecules such as polysaccharides.
17p viginny 30-12-2022 8 2 Download
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Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application of robust and high quality standard operating procedures (SOPs) is critical for accurate measurements.
12p viginny 23-12-2022 7 3 Download
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The aim of this work was to strengthen the evidence of using micro diatom frustule as a promising candidate for drug loading materials for both hydrophobic and hydrophilic drug models. The morphological, surface elemental composition of diatomite powder, a raw source of micro diatom frustules and purified diatomite to collect micro diatom frustule were investigated.
6p paddington36 04-01-2022 15 1 Download
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There may be great individual variability in the hemodynamic effects of this dexmedetomidine. For this reason, the dose must be carefully adjusted to achieve the desired clinical effect. Whether a loading dose of dexmedetomidine produces hemodynamic side effects during the anesthesia maintenance is unknown. The aim of this study was to compare the effects of a loading dose of dexmedetomidine combined with propofol or sevoflurane on hemodynamics during anesthesia maintenance.
9p vampires36 30-12-2021 11 0 Download