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Drug pathway
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YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.
18p
vishanshan
27-06-2024
1
1
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p
vishanshan
27-06-2024
2
1
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A new class of antibody-based drug therapy with the potential for disease modification is now available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of such disease modifying therapies (DMTs) necessitates adopting new treatment and care pathways.
12p
vishanshan
27-06-2024
2
1
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Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With the application of new chemotherapy regimens, finding new and effective anti-OS drugs to coordinate program implementation is urgent for the patients of OS.
11p
vikoch
27-06-2024
2
1
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Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene expression value is impacted by CNAs and leveraged this analysis at the pathway level.
14p
vikoch
27-06-2024
2
1
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Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic efficacy.
13p
vikoch
27-06-2024
3
1
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Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.
14p
vikoch
27-06-2024
1
1
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Ebook "Targeted therapies in cancer: Myth or Reality?" contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures.
200p
ladongphongthanh1008
22-04-2024
7
1
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Ebook "Synthesis and characterization of glycosides (Second edition)" is a short and comprehensive study on the best known approaches for preparing the main types of glycosides. It covers synthetic pathways of challenging glycosides known as antiviral or antineoplastic drugs, and synthetic substrates used for enzymatic detection, including those used for detection of gene markers in plant biotechnology. The author pays special attention to the structural characterization of glycosides and provides the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
432p
tracanhphuonghoa1007
22-04-2024
3
2
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The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered.
3p
vibransone
28-03-2024
5
2
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Precision oncology involves analysis of individual cancer samples to understand the genes and pathways involved in the development and progression of a cancer. To improve patient care, knowledge of diagnostic, prognostic, predisposing, and drug response markers is essential.
16p
vibransone
28-03-2024
4
2
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We present PhenCards (https://phencards.org), a database and web server intended as a one-stop shop for previously disconnected biomedical knowledge related to human clinical phenotypes. Users can query human phenotype terms or clinical notes. PhenCards obtains relevant disease/phenotype prevalence and co-occurrence, drug, procedural, pathway, literature, grant, and collaborator data.
9p
vibransone
28-03-2024
7
1
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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p
viellison
28-03-2024
1
1
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Ebook "Programmed cell death in cancer progression and therapy (Advances in experimental medicine and biology, Volume 615)" give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents.
362p
duongthandue0501
28-02-2024
1
1
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In ebook "Alternative splicing and disease" splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways.
265p
tachieuhoa
28-01-2024
4
2
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Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threat‑ ening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs for colon cancer therapies.
13p
vileonardodavinci
23-12-2023
4
3
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Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and targeting moieties could improve the therapeutic delivery of anti-cancer drugs.
14p
vileonardodavinci
23-12-2023
4
3
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CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in different breast cancer cell lines and explored its functional roles, including migration, invasion, drug resistance and modulation of key proteins associated with cancer progression.
11p
vileonardodavinci
23-12-2023
3
2
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Colorectal cancer is one of the most common cancer and the third leading cause of death worldwide. Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Several studies have reported that an increase in ROS production could affect the expression of proteins involved in ROS-scavenging, detoxification and drug resistance.
16p
vialfrednobel
23-12-2023
6
3
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Colorectal cancer is a common malignant tumour. Invasive growth and distant metastasis are the main characteristics of its malignant biological behaviour, and they are also the primary factors leading to death in colon cancer patients. Atovaquone is an antimalarial drug, and its anticancer effect has recently been demonstrated in several cancer models in vitro and in vivo, but it has not been examined in the treatment of colorectal cancer.
13p
vialfrednobel
23-12-2023
10
2
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