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Drug plasma concentrations
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p
vikoch
27-06-2024
1
1
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Due to the increasing number of therapeutic monoclonal antibodies (mAbs) used in the clinic, there is an increasing need for robust analytical methods to quantify total mAb concentrations in human plasma for clinical studies and therapeutic drug monitoring. We developed an easy, rapid, and robust sample preparation method for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.
10p
viginny
23-12-2022
8
3
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Midazolam is commonly used as a pre-anesthesia anxiolytic. Its elimination may not be fast enough for short procedures. In orally premedicated patients we obtained midazolam plasma concentrations at the end of surgical procedures and compared those to concentrations at anesthesia induction.
6p
viottohahn
30-03-2022
6
1
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The objective of this study was to determine the renal clearance of flunixin and meloxicam in pigs and compare plasma and urine concentrations and tissue residues. Urine clearance is important for livestock show animals where urine is routinely tested for these drugs.
10p
vigandhi
23-02-2022
12
2
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The pharmacokinetics and anti-inflammatory activity of andrographolide (50 mg/kg) were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC).
6p
angicungduoc8
07-11-2020
7
1
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In the present experiment the depletion profile study of Albendazole and its metabolites (ABZSO and ABZSO2) were carried out in the plasma of Pangasianodon hypophthalmus. The experiment consists of three treatment groups and control. A 20mg/kg body weight dose of ABZ was given through intraperitoneal, intramuscular and orally respectively to the three treatment groups while no drug was given to control group.
9p
nguathienthan8
20-10-2020
12
1
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Varying the rate of continuous intravenous infusions of 5-fluorouracil (5FU) chemotherapy over a 24-hour period has been reported to improve patient outcomes. It has been hypothesized that circadian variation in drug disposition is a contributing factor. We analyzed 5-FU concentrations during a 24-hour continuous 5-FU infusion
8p
vialabama2711
21-09-2020
12
1
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Tamoxifen, the most frequently used drug for treating estrogen receptor-positive breast cancer, must be converted into active metabolites to exert its therapeutic efficacy, mainly through CYP2D6 enzymes.
12p
viamsterdam
18-09-2020
12
1
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The pharmacokinetics of proton pump inhibitors (PPIs) may be affected by food intake. We aimed to evaluate the effect of food on the pharmacokinetics of omeprazole, rabeprazole, and pantoprazole.
9p
vidhaka2711
31-07-2020
37
1
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Poor compliance to highly active antiretroviral therapy (HAART) can result in the poor quality of life in children living with Human immunodeficiency virus/Acquired immunodeficiency syndrome (HIV/AIDS) because of low plasma drug concentration and the possibility of drug resistance.
10p
vimanama2711
28-07-2020
13
2
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Present study was conducted for pharmacokinetic interaction of long acting moxofloxacin (LA moxifloxacin) with meloxicam at the dose rate of 7.5 mg.kg-1 and 0.5 mg.kg-1 respectively following intramuscular (IM) administration. Peak plasma concentrations of drug were estimated by using HPLC florescence detector
5p
chauchaungayxua6
26-06-2020
11
0
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Pharmacokinetic activity of Quercetin (100 mg/kg) was studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC) following intramuscular administration of Quercetin (100 mg/kg) in rats.
5p
nguathienthan5
04-06-2020
13
1
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The pharmacokinetics, antibacterial and anti-inflammatory activities of Chrysin (100 mg/kg) were studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC).
10p
trinhthamhodang1213
30-05-2020
13
1
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Rivaroxaban, a novel oral anticoagulant drug, is widely used in clinical practice. There is no standardized laboratory monitoring for rivaroxaban, and its plasma concentration in Chinese patients with deep vein thrombosis is unclear.
8p
viorochimaru2711
30-05-2020
14
1
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The physiologically based pharmacokinetic (PBPK) model for liver transporter substrates has been established previously and used for predicting drug–drug interactions (DDI) and for clinical practice guidance. So far, nearly all the published PBPK models for liver transporter substrates have one or more hepatic clearance processes (i.e., active uptake, passive diffusion, metabolism, and biliary excretion) estimated by fitting observed systemic data.
11p
caothientrangnguyen
09-05-2020
18
0
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Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes especially for drugs like efavirenz whose plasma concentrations are directly related to treatment outcomes.
9p
vimax2711
30-03-2020
9
1
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The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicrobial action.
7p
vimax2711
27-03-2020
12
1
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Bio-enhancers such as piperine, curcumine, ginger and cow urine distillate are being seen as important adjuvant drugs to combat antimicrobial resistance and to increase efficiency of antimicrobial agents. Cow urine distillate is one of the important bio-enhancer easily available with farmer. The disposition kinetics was aimed to assess the pharmacokinetic alteration in profile of moxifloxacin, a third generation fluoroquinolone anti-microbial agent. Moxifloxacin was administered at the dose rate of 5 mg.
9p
chauchaungayxua3
07-02-2020
12
1
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Marbofloxacin is a third generation quinolone developed exclusively for veterinary use. The disposition kinetic profile of marbofloxacin was generated after a single intravenous bolus injection in male Sahiwal calves (n = 5) at the dose level of 2 mg.kg-1 body weight. Marbofloxacin concentrations in plasma were determined by microbiological assay using Escherichia coli MTCC 443 as the test organism. The plasma concentration–time profile following intravenous administration was best described by a two-compartment open model. The plasma drug concentration ≥ 0.12 μg.ml-1 was detected at 24 h.
8p
chauchaungayxua3
07-02-2020
13
1
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part 2 book “general and molecular pharmacology” has contents: control of drug plasma concentration, drug–receptor interactions- quantitative and qualitative aspects, receptors and modulation of their response, adaptation to drug response and drug dependence, pharmacological modulation of posttranslational modifications, calcium homeostasis within the cells,… and other contents.
425p
tieu_vu13
06-08-2018
23
2
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