Drug regulation

YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.

18p vishanshan 27-06-2024 1 1   Download

Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it is vital to determine the prognostic value and therapy response of PCD-related genes in OC.

17p vishanshan 27-06-2024 1 1   Download

High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism.

12p vishanshan 27-06-2024 1 1   Download

In this study, we investigated the therapeutic potential of bacteriostatic antibiotics in regulating the growth potential of colorectal cancer (CRC) cells, which differ in their metastatic potential and mitochondrial functions.

18p vikoch 27-06-2024 2 1   Download

Gemcitabine is a cornerstone drug for the treatment of all stages of pancreatic cancer and can prolong the survival of patients with pancreatic cancer, but resistance to gemcitabine in pancreatic cancer patients hinders its efficacy.

11p vikoch 27-06-2024 1 1   Download

Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene expression value is impacted by CNAs and leveraged this analysis at the pathway level.

14p vikoch 27-06-2024 2 1   Download

Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic efficacy.

13p vikoch 27-06-2024 3 1   Download

Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/carboplatin+bevacizumab a common chemotherapy regimen for stage IV non-squamous NSCLC; however, primary or acquired resistance to paclitaxel is gradually increasing, leading to treatment failure.

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The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed.

236p vimeyers 29-05-2024 5 2   Download

Ebook Drugs in sport is the most comprehensive and accurate text on the emotive, complex and critical subject of doping and illegal performance enhancement in sport. Thoroughly updated in light of the latest World Anti-Doping Code and taking into account the latest regulations, methods and landmark cases, this seventh edition explores the science behind drug-use in sport, as well as its ethical, social, political and administrative context.

431p vimeyers 29-05-2024 3 2   Download

The book also intervenes in the debate over off-label drug marketing and the proper role of the FDA before and after a drug goes on the market. Dealing honestly and thoroughly with the FDA's successes and failures, these essays rethink the structure, function, and future of the agency and the effect policy innovations may have on regulatory institutions abroad.

568p vimeyers 29-05-2024 3 2   Download

Part 1 book "Basic and clinical pharmacology" includes contents: Introduction - The nature of drugs and drug development and regulation, drug receptors and pharmacodynamics, pharmacokinetics and pharmacodynamics - rational dosing and the time course of drug action, drug biotransformation, pharmacogenomics, introduction to autonomic pharmacology; cholinoceptor activating and cholinesterase inhibiting drugs; cholinoceptor blocking drugs; adrenoceptor agonists and sympathomimetic drugs, adrenoceptor antagonist drugs,... and other contents.

502p dianmotminh01 17-05-2024 3 3   Download

Ebook "Networking of chaperones by co-chaperones" describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets.

152p ladongphongthanh1008 22-04-2024 4 4   Download

Ebook "Biology and regulation of blood-tissue barriers" was written by many outstanding investigators who have spent decades to study different aspects of blood‑tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood‑brain barrier, the blood‑retinal barrier, the gut barrier, the blood‑biliary barrier, the blood‑follicle barrier, the blood‑epididymis barrier, the blood‑testis barrier, the tight junction barrier in general as well as barriers in the female reproductive tract.

380p tracanhphuonghoa1007 22-04-2024 7 3   Download

Ebook "Systems for drug delivery: Safety, animal, and microbial polysaccharides" details current developments in all natural polymers, with a focus on animal and microbial polysaccharides. The book examines, compares, and contrasts the efficiency of plant and algae based natural polymers in inducing immune reactions. Additionally, the book details the safety and toxicity profiles with respective regulations.

205p tracanhphuonghoa1007 22-04-2024 8 2   Download

Part 2 book "Fowler's zoo and wild animal medicine current therapy" includes content: Fish medicine updates, antibiotic resistance in public aquariums, harmful algal blooms, emerging infectious diseases of reptiles, tropical avian diseases, avian hatching assistance, egg necropsies, electrocution of raptors, update on the status of vultures and nonsteroidal antiinflammatory drug regulations,....and other contents.

424p muasambanhan10 03-04-2024 5 1   Download

Medical digital twins are computational disease models for drug discovery and treatment. Unresolved problems include how to organize and prioritize between disease-associated changes in digital twins, on cellulomeand genome-wide scales. We present a dynamic framework that can be used to model such changes and thereby prioritize upstream regulators (URs) for biomarker- and drug discovery.

21p viellison 28-03-2024 5 2   Download

Ebook "Metallocorroles for attenuation of atherosclerosis" shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

101p coduathanh1122 27-03-2024 4 1   Download

Ebook "Programmed cell death in cancer progression and therapy (Advances in experimental medicine and biology, Volume 615)" give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents.

362p duongthandue0501 28-02-2024 1 1   Download

Ebook "Standardization and quality assurance in fluorescence measurements I: Techniques" is still in its infancy as compared to other prominent analytical and bioanalytical methods. Appropriate quality assurance standards are however a prerequisite for applications in highly regulated fields such as medical diagnostics, drug development, or food analysis. For the first time, a team of recognized international experts has documented the present status of quality assurance in fluorescence measurements, and outlines concepts for establishing standards in this field.

499p manmanthanhla0201 27-02-2024 4 1   Download