Drug resistance Pseudomonas aeruginosa
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This paper analyses a surveillance system dataset in order to describe the epidemiology of HAIs (MDROs and nonMDROs) in the intensive care unit (ICU), King Fahad Hofuf Hospital (KFHH), Saudi Arabia. The three year period (2010 to 2012) of KFHH surveillance system data (both sporadic and outbreak) were analysed.
19p vikissinger 21-12-2023 3 2 Download
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PhzM and PhzS aUe WZR ³cRUe´ eQ]\PeV WhaW aUe QeceVVaU\ fRU cRQYeUViRQ Rf SheQa]iQe-1- carboxylic acid (PCA) into pyocyanin (PYO) phenazine in Gram (-) bacterium Pseudomonas aeruginosa. Apparently, the raise in copy number of their genes could increase the amount of pyocyanin phenazine in the microbe.
8p vimulcahy 18-09-2023 4 3 Download
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Gram-negative bacteria are increasingly responsible for nosocomial infections, including ICU-acquired infections. Due to high virulence, rate of multi-drug resistance and limited availability of new agents, these infections create cumbersome clinical burdens, making it important to reduce the risk of their occurrence.
7p viisaacnewton 25-04-2022 14 2 Download
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Understanding the RNA processing of an organism’s transcriptome is an essential but challenging step in understanding its biology. Here we investigate with unprecedented detail the transcriptome of Pseudomonas aeruginosa PAO1, a medically important and innately multi-drug resistant bacterium. We systematically mapped RNA cleavage and dephosphorylation sites that result in 5′-monophosphate terminated RNA (pRNA) using monophosphate RNA-Seq (pRNA-Seq).
20p vibeauty 23-10-2021 10 0 Download
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A critical goal in biology is to relate the phenotype to the genotype, that is, to find the genetic determinants of various traits. However, while simple monofactorial determinants are relatively easy to identify, the underpinnings of complex phenotypes are harder to predict.
17p visilicon2711 20-08-2021 11 1 Download
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The study was carried out on 160 Pseudomonas aeruginosa isolates. Samples had been cultured, identified and tested for sensitivity. A phenotypic test (Double disc synergy test) was applied on the collected MDR isolates for detection of MBL enzyme production. Conventional PCR was performed for the detection of the resistance gene(blaVIM). 100 isolates were multi-drug resistant according to (Modified Kirby Bauer disc diffusion method), with sensitivity to some drugs specially Amikacin (20%). Phenotypic test for MBL resulted in (38%) positive isolates and (62%) were negative ones.
9p trinhthamhodang11 27-04-2021 13 2 Download
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Furthermore, infections with multi-drug resistant pathogens whether in hospitals or in the community increase morbidity, decrease treatment success, reduce hospital turn-over rate and increase cost of patient care (Alebachew et al., 2012).
9p caygaocaolon11 21-04-2021 22 1 Download
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The present study was carried out to detect bacteria commonly associated in causation of VAP. Also to determine their antibiotic susceptibility patterns as well as to detect the presence of ESBL, AmpC β-lactamases, carbapenemases and MBL in these VAP pathogens.
8p cothumenhmong9 18-01-2021 8 0 Download
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Pseudomonas aeruginosa is a gram negative bacillus that colonizes in moist environment of the hospital settings with occurrence of antimicrobial resistance. Increasing resistance to beta-lactam drugs, especially the 3rd-generation cephalosporins, in Pseudomonas aeruginosa is predominantly due to the production of extended spectrum beta-lactamases (ESBLs). This was a laboratory based observational study carried out over a period of 7 months from April 2019 to December 2019.
10p nguaconbaynhay7 15-08-2020 14 1 Download
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The study was aimed to determine the prevalence and drug resistance pattern of P. aeruginosa in SSI. Over a 2-year period, specimens were received as postoperative wound swabs in Microbiology department and processed for isolation and identification of bacterial pathogens, according to the standard microbiological techniques.
5p trinhthamhodang6 09-07-2020 15 2 Download
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The present study was conducted to evaluate antimicrobial and cytotoxicactivity of Sisymbrium irio L extract against MDRB (Staphylococcus aureus, Enterococcus faecium, Klebsiella pneumoniae, Acinetobacter baumanni, Enterobacter cloacae and Pseudomonas aeruginosa) and Candida albicans. Antibiotic sensitivity profile was performed using disc diffusion method. Cytotoxicity was measured against African Green Monkey Kidney (VERO) cell line using the colorimetric MTT assay.
13p kethamoi6 29-06-2020 10 1 Download
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Now-a-days, many antibiotics are being used to control infectious diseases. Inappropriate use of antibiotics leads to emergence of highly resistant bacteria. The increasing resistance of microorganism to conventional chemicals and drugs is a serious global problem that has opened up the promotion research into the identification of new biocides with broad activity.
7p chauchaungayxua6 26-06-2020 15 1 Download
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Resistance to carbapenems are because of various mechanisms like mutations in the outer membrane proteins like Opr D causing decreased permeability of the drugs, the carbapenem hydrolyzing enzymes–carbapenemases and the efflux mechanisms. Carbapenem resistance was studied in 140 non-repeat clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital. Imipenem resistance was detected using Kirby Bauer’s standard disc diffusion method. MIC for Imipenem was detected in all resistant isolates using E-test strips.
7p chauchaungayxua6 26-06-2020 14 2 Download
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Pseudomonas aeruginosa is an important cause of hospital acquired infection especially in patients admitted in critical care units such as intensive care units and burn care units. In recent times, it has emerged as a widespread Multi Drug Resistant (MDR) pathogen which requires antibiotic susceptibility testing on a regular as well as a periodic basis. This study was carried with an aim to determine the antimicrobial resistance pattern and prevalence of MDR P. aeruginosa infection among burns patients at a tertiary care center.
6p nguaconbaynhay6 24-06-2020 10 2 Download
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Objective of the research was to validate the potential of Syzygium aromaticum and Kaempheria galanga against biofilm formation and plasmid borne drug resistance exhibited by Pseudomonas spp. Antimicrobial property of S.aromaticum and K.galanga on P.aeruginosa culture was assessed using the agar well diffusion method. Crystal violet assay was employed to determine the percentage inhibition of P.aeruginosa biofilm by the extracts following generation of biofilm on multiwell plates.
7p nguaconbaynhay6 23-06-2020 31 0 Download
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Evolution of multi drug resistant isolates has become rampant in today’s world. The credit of this goes to the incomplete dosage and irrational use of antibiotics. The human brains are now in search of alternate methods. Use of Silver nanoparticles is one amongst them. In the following study, 50 multi-drug resistant clinical isolates of P. aeruginosa acquired from the intensive care units were tested with antibiotics, AgNps and AgNp-antibiotic conjugates. The conjugates were prepared by impregnating 30 µl of AgNps in sterile plain disks and the antibiotic disks separately.
6p angicungduoc5 14-06-2020 28 1 Download
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The severity and extent of disease caused by multidrug-resistant organisms (MDROs) varies by the population(s) affected and the institution(s) at which these organisms are found; therefore, preventing and controlling MDROs are extremely important.
11p angicungduoc5 12-06-2020 6 0 Download
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The aim of this study was to analyze the extended spectrum of β lactamase (ESBL), metallo β lactamase (MBL) and AmpC production in Pseudomonas aeruginosa in various clinical samples. A Total of 100 clinical isolates of P. aeruginosa were collected from different clinical specimen and confirmed by standard tests. Antibiotic susceptibility was determined by the Kirby-Bauer disc diffusion method. ESBL screening was done using 3rd generation cephalosporins and confirmatory combined double disc test, imipenem-EDTA double disc synergy test for MBL enzyme and AmpC test using Cefoxitin disc.
9p trinhthamhodang1213 30-05-2020 11 1 Download
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Pseudomonas aeruginosa is an opportunistic pathogen and is the leading cause of nosocomial infections especially among patients admitted to ICU and burn units. It has natural resistance as well as acquired multi drug resistance to various antibiotics leading to increased morbidity and mortality. Aim of the study is to isolate P. aeruginosa from burn and ICU patients and to evaluate multidrug resistance. Samples were collected from 100 patients from both ICUs and burn unit for a period of 15 months. Samples were processed in the Microbiology laboratory by standard bacteriological methods.
8p caygaocaolon4 01-04-2020 10 1 Download
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Most common bacterial agents of Lower Respiratory Tract Infection in the Intensive Care Units are Pseudomonas, Acinetobacter, Klebsiella, Citrobacter; which are multi drug resistant, and with limiting the therapeutic options.Nonfermenting Gram-negative bacilli are known to produce Extended spectrum β-lactamases (ESBLs) and metallo β-lactamases. Pseudomonas aeruginosa and Acinetobacter spp. in particular are most often associated with carbapenem resistance.
9p chauchaungayxua4 18-03-2020 16 2 Download