Drug susceptibility testing

Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings.

7p vibransone 28-03-2024 3 2   Download

A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret wholegenome sequencing data for genotypic drug susceptibility testing (DST).

8p vibransone 28-03-2024 3 2   Download

Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MDR tuberculosis (MDR-TB) in Eswatini.

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The emergence of resistance to anti-tuberculosis drugs is a serious and growing threat to public health. Next-generation sequencing is rapidly gaining traction as a diagnostic tool for investigating drug resistance in Mycobacterium tuberculosis to aid treatment decisions. However, there are few little data regarding the precision of such sequencing for assigning resistance profiles.

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Whether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the association between BP and risk of AF is causal, (2) whether it varies according to individual’s genetic susceptibility for AF, and (3) the extent to which specific BP-lowering drugs are expected to reduce this risk.

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Multidrug-resistant Mycobacterium tuberculosis (Mtb) is a significant global public health threat. Genotypic resistance prediction from Mtb DNA sequences offers an alternative to laboratory-based drugsusceptibility testing. User-friendly and accurate resistance prediction tools are needed to enable public health and clinical practitioners to rapidly diagnose resistance and inform treatment regimens.

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Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to one-fourth of the global MDR tuberculosis (TB) burden.

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Part 1 book "Concise review of veterinary microbiology" includes content: Structure of bacterial cells; cultivation, preservation and inactivation of bacteria; bacterial genetics and genetic variation; molecular diagnostic methods; laboratory diagnosis of bacterial disease; molecular subtyping of bacteria; antibacterial agents; antimicrobial susceptibility testing; bacterial resistance to antimicrobial drugs,... and other contents.

106p oursky10 04-12-2023 4 3   Download

Part 2 book "Updates on brucellosis" includes content: Blood cultures for the diagnosis of human brucellosis, antibiotic susceptibility testing of brucella species - old and new drugs, recombinant proteins as antigens in serological diagnosis of brucellosis, treatment of brucellosis, treatment of human brucellosis — review of evidence from clinical trials, control of animal brucellosis — the most effective tool to prevent human brucellosis.

144p oursky09 08-11-2023 4 2   Download

Part 1 book "Antimicrobial resistance - In bacteria from livestock and companion animals" includes content: History and current use of antimicrobial drugs in veterinary medicine, antimicrobial susceptibility testing of bacteria of veterinary origin, molecular methods for the detection of antimicrobial resistance, mechanisms of bacterial resistance to antimicrobial agents, resistance to metals used in agricultural production,.... and other contents.

347p oursky04 14-09-2023 4 2   Download

Part 1 of ebook "Antimicrobial therapy in veterinary medicine (Fifth edition)" presents the following content: general principles of antimicrobial therapy; classes of antimicrobial agents; antimicrobial susceptibility testing methods and interpretation of results; principles of antimicrobial drug selection and use; other beta-lactam antibiotics - beta-lactamase inhibitors, carbapenems, and monobactams;...

358p dieptieuung 14-07-2023 2 1   Download

Drug resistant tuberculosis (DR-TB) remains a global health problem. The diagnosis, treatment, and management of DR-TB are the major challenges to Vietnam National Tuberculosis Control Program. One of the most important solutions for overcoming this problem is developing reliable and low-cost methods, which have been proposed to Drug Susceptibility Testing (DST) to detect drug resistant tuberculosis. The methods have to be reasonably simple so that they can be widely used in provincial Lung hospitals.

6p cothumenhmong11 06-05-2021 22 2   Download

Hospital acquired Candida infection is a major cause of morbidity and mortality especially in critically ill and immunocompromised patients. Therefore, an accurate and early identification is necessary for the management of patients. The aim of our study was rapid identification of Candida species and their antifungal susceptibility testing (AST) by VITEK 2 system in hospital acquired fungal infections.

9p cothumenhmong9 18-01-2021 16 1   Download

Hence this study was undertaken to understand the drug susceptibility pattern of Mycobacterium tuberculosis isolated from EPTB specimens in this region of South India.

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Tuberculosis remains as one of the leading cause of morbidity and mortality globally. Estimated cases of around 9.6 million are affected by all forms of TB worldwide, out of which 2.2 billion are affected in India. India also has the second highest burden of MDR TB after China. Information on MDR TB is sparse in Raichur District. We undertook this study to detect MDR TB among MDR suspected cases and its common mutation using Genotype MTBDR plus. All presumptive MDR sputum samples were sent to DST LAB RIMS, Raichur from various part of Raichur district.

7p gaocaolon9 22-12-2020 13 1   Download

The objectives of this study was identification and detection of biofilm production in Candida species isolated from catheterized and Non-catheterized candiduria patients hospitalized in NRI general hospital and their antifungal susceptibility patterns.

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The present study was undertaken from 30/6/11 – 14/8/12 to know the Bacterial, and Mycological profile profile and drug susceptibility patterns in children suffering from pneumonias. Sputa (expectorated and induced) and Pleural fluid were collected from 113 cases and processed by conventional methods. Antibiotic sensitivity testing of these isolates was done as per CLSI guidelines.

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Blood infection due to Candida species are major cause of morbidity and mortality in hospitalised patients. The spectrum of candidemia has changed to Non albicans Candida species and also shows resistance to commonly used azoles drugs. To study prevalence of Candida species isolated from blood culture samples and to isolate and identify different Candida species with their antifungal susceptibility testing. Blood samples were collected and incubated in automated blood culture system.

9p trinhthamhodang1215 23-09-2020 15 1   Download

Klebsiella pneumonia is a gram negative bacilli and it produce pneumonia in sheep. In present study isolation of klebsiella pneumonia from sheep die due to pneumonia. Klebsiella pneumonia produces large dome shape, mucoid colony on BHI agar and Lactose fermenting pink colony on Mac conkey agar. It conform by biochemical test like indole negative, MR negative, VP positive, Citrate positive, Oxidase negative and catalase positive. In Antibiotic Sensitivity Test higher susceptible drug was Chloramphenicol against Klebsiella pneumoniae.

4p trinhthamhodang7 31-08-2020 20 1   Download

The study was aimed to determine the prevalence and drug resistance pattern of P. aeruginosa in SSI. Over a 2-year period, specimens were received as postoperative wound swabs in Microbiology department and processed for isolation and identification of bacterial pathogens, according to the standard microbiological techniques.

5p trinhthamhodang6 09-07-2020 15 2   Download