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Drug use
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p
vishanshan
27-06-2024
2
1
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Determination of drug-related problems in the hematology service: A prospective interventional study
Patients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects.
8p
vishanshan
27-06-2024
2
1
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The need for intelligent and effective treatment of diseases and the increase in drug design costs have raised drug repurposing as one of the effective strategies in biomedicine. There are various computational methods for drug repurposing, one of which is using transcription signatures, especially single-cell RNA sequencing (scRNAseq) data, which show us a clear and comprehensive view of the inside of the cell to compare the state of disease and health.
11p
vishanshan
27-06-2024
1
1
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Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a spe‑ cifc protein is a foundation of precision medicine and treatment. High expression of the proto-oncogene Bcl-3 promotes the proliferation and metastasis of cancer cells originating from tissues such as the colon, prostate, breast, and skin.
12p
vishanshan
27-06-2024
1
1
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The etonogestrel contraceptive implant is currently approved by the United States Food and Drug Administration (FDA) for the prevention of pregnancy up to 3 years. However, studies that suggest efficacy up to 5 years. There is little information on the prevalence of extended use and the factors that infuence clinicians in offering extended use.
9p
vishanshan
27-06-2024
1
1
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In 2016, Uganda added Hydroxyurea (HU) to the list of essential drugs to treat sickle cell disease SCD. However, Hydroxyurea utilization has been low for several countries in sub-Saharan Africa. This study examined patient-related barriers to hydroxyurea use among adolescent and adult patients with sickle cell disease in Mulago and Kiruddu hospitals, in Uganda.
18p
vishanshan
27-06-2024
1
1
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This study aimed to examine the reporting quality of existing economic evaluations for negotiated glucose-lowering drugs (GLDs) included in China National Reimbursement Drug List (NRDL) using the Consolidated Health Economic Evaluation Reporting Standards 2013 (CHEERS 2013).
10p
vishanshan
27-06-2024
1
1
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Female gynecological cancers represent a serious public health problem, with 1,398,601 new diagnoses and 671,875 deaths per year worldwide. Antipsychotics are often used in psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. It is estimated that the prescription of these drugs is linked to 1,800 deaths a year in the United States, but their association with cancer remains controversial.
10p
vikoch
27-06-2024
1
1
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Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address this gap, we performed a two-sample Mendelian randomization (MR) analysis to identify potential therapeutic targets for CRC.
14p
vikoch
27-06-2024
1
1
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Drug repurposing provides a cost-effective approach to address the need for lung cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR).
10p
vikoch
27-06-2024
1
1
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For drugs reimbursed with limited evidence of patient benefits, confirmatory evidence of overall survival (OS) and quality of life (QoL) benefits is important. For QoL data to serve as valuable input to patients and decisionmakers, it must be measured and analyzed using appropriate methods. We aimed to assess the measurement and analyses of post-reimbursement QoL data for cancer drugs introduced in Swedish healthcare with limited evidence at the time of reimbursement.
13p
vikoch
27-06-2024
1
1
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Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved.
12p
vikoch
27-06-2024
1
1
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The partitioned survival model (PSM) and the state transition model (STM) are widely used in costeffectiveness analyses of anticancer drugs. Using different modeling approaches with or without consideration of brain metastasis, we compared the quality-adjusted life-year (QALY) estimates of Osimertinib and pemetrexedplatinum in advanced non-small cell lung cancer with epidermal growth factor receptor mutations.
11p
vikoch
27-06-2024
1
1
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Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.
12p
vikoch
27-06-2024
1
1
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In this study, an analytical chemistry practice was established and validated via the quantification of ibuprofen in drugs using the UHPLC-PDA/MS analysis for undergraduate students. These findings demonstrate that the analytical procedure is a promising and effective method for establishing the analytical chemistry practice to meet the general education curriculum 2018 in Vietnam and serve as a valuable reference for students and teachers.
16p
visergeyne
18-06-2024
2
0
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Part 2 book "Small animal cardiovascular medicine" includes content: Feline unclassified and restrictive cardiomyopathy; heartworm infection and disease (dirofilariasis); infective endocarditis (and annuloaortic ectasia); pericardial disease and cardiac neoplasia; pulmonary arterial and systemic arterial hypertension; diagnosis and treatment of arrhythmias (dysrhythmias); syncope; drugs used in treatment of cardiac arrhythmias; interventional antiarrhythmic therapy; thromboembolic disease; the effects of systemic disease on the cardiovascular system.
604p
dianmotminh03
17-06-2024
0
0
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This easy-to-understand, consumer-friendly guide helps you find out whether Part D affects any drug coverage you already have and weigh the consequences of going without coverage. And you’ll learn how to minimize your expenses, use the “right” pharmacies, and troubleshoot any problems with your coverage. Discover how to: Decide whether you need Part D; Understand how Part D works, from costs to coverage; Choose and enroll in the best plan for you;...
386p
zizaybay1104
29-05-2024
4
2
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Our goals in writing this book are to confirm that IBS is real and to show you the many ways you can successfully deal with your symptoms. Because there is no wonder drug to cure IBS, people desperate for help try all sorts of therapies to find relief. We sort through the good, the bad, and the ugly and present you with the best of the best remedies and therapies for IBS. While reading this book from beginning to end would make you an IBS genius, you don’t really have to do that. You can read Chapter 1 and get a great overview of the book.
386p
zizaybay1104
29-05-2024
1036
1
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This book is for readers with some background in science, concerning the search for drugs, starting from molecular diversity in nature or molecular wilderness. Drug molecules may be used as such, or as starting points for improved drugs obtained from the interface of chemistry and biology.
162p
vimeyers
29-05-2024
3
2
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Ebook Drugs in sport is the most comprehensive and accurate text on the emotive, complex and critical subject of doping and illegal performance enhancement in sport. Thoroughly updated in light of the latest World Anti-Doping Code and taking into account the latest regulations, methods and landmark cases, this seventh edition explores the science behind drug-use in sport, as well as its ethical, social, political and administrative context.
431p
vimeyers
29-05-2024
3
2
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