![](images/graphics/blank.gif)
Durable disease
-
Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive disease and poor outcome.
3p
vibransone
28-03-2024
2
2
Download
-
Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.
322p
duongthandue0501
28-02-2024
3
1
Download
-
The gut microbiome plays an important role in immune modulation. Specifically, presence or absence of certain gut bacterial taxa has been associated with better antitumor immune responses. Furthermore, in trials using fecal microbiota transplantation (FMT) to treat melanoma patients unresponsive to immune checkpoint inhibitors (ICI), complete responses (CR), partial responses (PR), and durable stable disease (SD) have been observed.
11p
vileonardodavinci
23-12-2023
7
2
Download
-
Despite a global decrease in malaria burden worldwide, malaria remains a major public health concern, especially in Benin children, the most vulnerable group. A better understanding of malaria’s spatial and agedependent characteristics can help provide durable disease control and elimination.
15p
viferrari
29-10-2022
2
2
Download
-
Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. Alltrans retinoic acid (ATRA) and/or arsenic trioxide (ATO) have resulted in durable cytogenetic and molecular remissions in most APL patients and have altered the natural history of the disease.
9p
vimahuateng
26-11-2021
9
1
Download
-
Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with a variety of advanced solid tumors. However, we not infrequently encounter patients with hyperprogressive disease (HPD) exhibiting paradoxically accelerated tumor growth with poor clinical outcomes.
11p
vianrose2711
27-04-2021
7
1
Download
-
The study evaluates the most important quality criteria of shoe material for patients with foot disease (durability, water vapor permeability, absorption, antibacterial activity) as a basis. The basis for selecting materials and processing high quality shoes is the necessary work.
6p
chauchaungayxua11
23-03-2021
15
2
Download
-
Rice is staple food for more than half of the world’s population. The fast growth of the world population demands an increase of 26 % in rice production to fulfill the requirement. The rice blast caused by Magnaporthe oryzae is considered to be the most significant and potentially damaging rice disease in the world and has been responsible for 35 to 50 % global loss in rice yield causing serious constraint in global food supply.
7p
nguathienthan8
20-10-2020
5
1
Download
-
In this study, we examined patients who had non-progressive disease for at least 2 years after diagnosis of inoperable locoregional recurrent or metastatic breast cancer under continuous trastuzumab treatment. Our primary goal was to assess the long-term outcome of patients with durable response to trastuzumab.
7p
vilisa271
22-09-2020
12
0
Download
-
Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the efficacy and tolerability of olaparib, a PARP inhibitor, in patients with advanced Ewing sarcoma (EWS) progressing after prior chemotherapy.
6p
vilisa271
22-09-2020
12
0
Download
-
Treatment of pulmonary recurrence from colorectal cancer involving the main bronchus usually entails palliation using interventional bronchoscopy, because the prognosis is generally very poor. Surgical experience has clarified that in this setting pneumonectomy should only be performed in carefully selected patients showing favorable prognostic profiles (defined by low carcinoembryonic antigen serum levels pre-thoracotomy), solitary and completely resectable pulmonary metastasis, and long disease-free intervals.
6p
viamsterdam
18-09-2020
14
0
Download
-
Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement. The standard of care is surgical resection. Observations suggest that low dose chemotherapy is beneficial. The treatment of resistant or relapsed patients with multifocal disease remains challenging.
7p
vimale2711
21-08-2020
7
1
Download
-
Stem rust is one of the most prevailing diseases of wheat crop severely affecting yield. The disease constrains wheat production and henceforth lags the demand. Identifying genes providing resistance from stem rust has been quite important in present scenario. One such gene providing resistance to stem rust is Sr2 which has provided durable, broad-spectrum, adult plant resistance and has been used as a potential control measure against wheat stem rust in modern wheat breeding programs worldwide.
6p
angicungduoc6
22-07-2020
8
1
Download
-
Papaya is major tropical fruit gaining importance throughout the tropics and subtropics but there is a severe restriction in its production due to the serious disease known as Papaya Ring Spot Virus (PRSV-P). No papaya variety till date was identified as having durable resistance to PRSV-P; whereas several species of Vasconcellea, a close relative of papaya was reported to have heritable resistance to Papaya Ring Spot Virus.
7p
kethamoi5
03-06-2020
12
0
Download
-
Crown rust, caused by Puccinia coronata f. sp. avenae, is the most important disease of oat worldwide. Adult plant resistance (APR), based upon partial resistance, has proven to be a durable rust management strategy in other cereal rust pathosystems.
11p
viminato2711
22-05-2020
10
0
Download
-
Despite the fact that rising global population requires increased crop production, the rate of increase in crop yields is currently declining. The traits related to yield, stability and sustainability should be a major focus of plant breeding efforts. These traits include durable disease resistance, abiotic stress tolerance along with nutrient and water use efficiency. The use of DNA markers in plant breeding is called marker assisted selection (MAS).
6p
nguaconbaynhay5
11-05-2020
11
1
Download
-
Powdery mildew (PM) is a widespread fungal disease of plants in temperate climates, causing significant economic losses in agricultural settings. Specific homologs of the MLO gene family are PM susceptibility factors, as their loss-of function results in durable PM resistance (mlo resistance) in several plant species.
11p
vishikamaru2711
25-04-2020
10
1
Download
-
Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a major threat to wheat production and food security worldwide. Breeding stably and durably resistant cultivars is the most effective approach for managing and controlling the disease.
13p
viharuno2711
21-04-2020
5
1
Download
-
Pinellia ternata is a Chinese traditional medicinal herb, used to cure diseases including insomnia, eclampsia and cervical carcinoma, for hundreds of years. Non-self-recognition in multicellular organisms can initiate the innate immunity to avoid the invasion of pathogens
14p
viharuno2711
24-04-2020
10
1
Download
-
Witches’ broom disease (WBD) of cacao (Theobroma cacao L.), caused by Moniliophthora perniciosa, is the most important limiting factor for the cacao production in Brazil. Hence, the development of cacao genotypes with durable resistance is the key challenge for control the disease.
21p
viharuno2711
21-04-2020
7
1
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)