Dynamic protein phosphorylation

β -arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in the field of GPCR-mediated pharmacology. However, impact of these mutations on function of these variants has remained elusive. In this study, structural and dynamical properties of one of β -arrestin2 (arrestin 3) variants, A248T, which has been identified in some cancer tissue samples, were investigated via molecular dynamics simulations.

12p tudichquannguyet 29-11-2021 3 1   Download

Dynamic protein phosphorylation is an essential regulatory mechanism in various organisms. In this capacity, it is involved in a multitude of signal transduction pathways. Kinase-specific phosphorylation data lay the foundation for reconstruction of signal transduction networks.

8p viwyoming2711 16-12-2020 10 1   Download

Phosphorylation is one of the most important post-translational modifications (PTM) employed by cells to regulate several cellular processes. Studying the effects of phosphorylations on protein structures allows to investigate the modulation mechanisms of several proteins including chaperones, like the small HSPs, which display different multimeric structures according to the phosphorylation of a few serine residues.

10p vioklahoma2711 19-11-2020 11 1   Download

Protein kinases are important components of signalling pathways, and kinomes have remarkably expanded in plants. Yet, our knowledge of kinase substrates in plants is scarce, partly because tools to analyse protein phosphorylation dynamically are limited.

13p vihashirama2711 21-05-2020 10 2   Download

Post-translational modifications, such as phosphorylation and acetylation of the tumour suppressor protein p53, elicit important effects on the func-tion and the stability of the resultant protein. However, as phosphorylation and acetylation are dynamic events subject to complex controls, elucidating the relationships between phosphorylation and acetylation is difficult.

7p awards 06-04-2013 31 2   Download

In response to the need for an all encompassing treatment device to deal with trash, debris (organic and non organic) solids, sediment, total suspended solids (“TSS”), metals (dissolved/particulate), nutrients (dissolved/particulate), oils, hydrocarbons, polycyclic aromatic hydrocarbons (“PAH”), and pathogenic bacterium contaminants, the City of Oceanside authorized the installation of the Modular Wetlands Device in April of 2008.

6p tainhacmienphi 19-02-2013 31 3   Download

Phosphorylated derivatives of the membrane lipid phosphatidylinositol (PtdIns), known as phosphoinositides (PIs), regulate membrane-proximal cellular processes by recruiting specific protein effectors involved in cell signalling, membrane trafficking and cytoskeletal dynamics. Two PIs that are generated through the activities of distinct PI 3-kinases (PI3Ks) are of special interest in cancer research.

12p mobifone23 08-01-2013 35 2   Download

The phosphorylation and trafficking ofN-methyl-D-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point of convergence for many signaling pathways that upregulate GluN2B-containing NMDA receptors.

8p cosis54 08-12-2012 41 1   Download