Early and late apoptosis
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To determine whether ceramide is responsible for the induction of p53-independent early or late apoptosis in response to high- and low-Linear-Energy-Transfer (LET) irradiation. Methods: Four cell lines displaying different radiosensitivities and p53-protein status were irradiated with photons or 33.4 or 184 keV/μm carbon ions.
11p vijisoo2711 29-09-2020 11 1 Download
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Cancer remains one of the leading causes of death around the world, where incidence and mortality rates are at a constant increase. Tumourigenic cells are characteristically seen to over-express the 37 kDa/67 kDa laminin receptor (LRP/LR) compared to their normal cell counterparts.
11p vibaku2711 22-07-2020 25 2 Download
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The effect increased significantly at the concentration of 50 µM, the homoisoflavanone generated apoptosis in 83.8% of cells (23.5% early apoptosis and 60.3% late apoptosis). Treatment with homoisopogon A for 48h also resulted in typical apoptotic morphological changes in A549 cells under microscopic observation. The results strongly suggested that homoisopogon A induces apoptosis in EGFR and TKI-resistant-A549 cells, thus resulting in the cytotoxicity.
5p nguyenhong1235 28-11-2018 24 1 Download