Early infant HIV diagnosis

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Evaluating patient data quality in South Africa’s National Health Laboratory Service Data Warehouse, 2017-2020: Implications for monitoring child health programmes

South Africa’s National Health Laboratory Service (NHLS), the only clinical laboratory service in the country’s public health sector, is an important resource for monitoring public health programmes.

10p viferrari 28-11-2022 8 2 Download

Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: A prospective cohort study

As HIV-infected infants have high mortality, the World Health Organization now recommends initiating antiretroviral therapy as early as possible in the first year of life. However, in many settings, laboratory diagnosis of HIV in infants is not readily available.

7p virubber2711 21-03-2020 13 1 Download

Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting

The aim of this study was to develop an economical ‘in-house’ single round polymerase chain reaction (PCR) assay using filter paper-dried blood spots (FP-DBS) for early infant HIV-1 diagnosis and to evaluate its performance in an African setting.

8p virubber2711 21-03-2020 12 1 Download
Disclosure, stigma of HIV positive child and access to early infant diagnosis in the rural communities of OR Tambo District, South Africa: A qualitative exploration of maternal perspective

Despite the overwhelming evidence confirming the morbidity and mortality benefits of early initiation of highly active anti-retroviral therapy (HAART) in HIV-infected infants, some children are still disadvantaged from gaining access to care.

10p vichengshin2711 26-02-2020 17 1 Download
High mortality in HIV-infected children diagnosed in hospital underscores need for faster diagnostic turnaround time in prevention of mother-to-child transmission of HIV (PMTCT) programs

Despite expanded programs for prevention of mother-to-child HIV transmission (PMTCT), HIV-infected infants may not be diagnosed until they are ill. Comparing HIV prevalence and outcomes in infants diagnosed in PMTCT programs to those in hospital settings may improve pediatric HIV diagnosis strategies.

7p vichengshin2711 26-02-2020 13 0 Download
Prevention and care of paediatric HIV infection in Ouagadougou, Burkina Faso: Knowledge, attitudes and practices of the caregivers

The paediatric Human Immunodeficiency Virus (HIV) epidemic still progresses because of operational challenges in implementing prevention of mother-to-child HIV transmission (PMCT) programs. We assessed the knowledge, attitudes and practices (KAP) of children’s caregivers regarding mother-to-child transmission (MTCT) of HIV, paediatric HIV infection, early infant diagnosis (EID), and paediatric antiretroviral treatment in Ouagadougou, Burkina Faso.

7p vichengna2711 25-02-2020 13 0 Download
Use of mobile phones and text messaging to decrease the turnaround time for early infant HIV diagnosis and notification in rural Zambia: An observational study

Early infant diagnosis of HIV infection is challenging in rural sub-Saharan Africa as blood samples are sent to central laboratories for HIV DNA testing, leading to delays in diagnosis and treatment initiation. Simple technologies to rapidly deliver results to clinics and notify mothers of test results would decrease many of these delays.

9p videshiki2711 19-02-2020 17 1 Download
HIV prevalence and risk factors in infants born to HIV positive mothers, measured by dried blood spot real-time PCR assay in Tigray, Northern Ethiopia

Infants infected during pregnancy or while breastfeeding requires early HIV diagnosis at 6 weeks after birth to identify HIV infection and timely treatment. The objective of this work was to determine the prevalence and associated risk factors of HIV among HIV exposed infants in the Tigray regional state, Northern Ethiopia.

8p virome2711 13-01-2020 8 0 Download
Clinical trials in gynecological cancer

Specific micronutrient deficiencies may affect maternal and foetal health. Iodine deficiency during pregnancy may cause foetal brain damage and mental retardation in infants. Vitamin A deficiency increases the risk in pregnant women of infection and anaemia, may cause blindness during pregnancy and early lactation, and has been associated to an elevated risk of HIV mother-to-child transmission. Folate deficiency may cause severe foetal neural tube defects like anencephaly and spina bifida.

10p connicquy 20-12-2012 62 10 Download