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Effect modification
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International guidelines recommend ivosidenib followed by modifed FOLFOX (mFOLFOX) for advanced intrahepatic cholangiocarcinoma (ICC) with isocitrate dehydrogenase 1 (IDH1) mutations. Taiwan National Health Insurance covers only fluorouracil/leucovorin (5-FU/LV) chemotherapy for this ICC group, and there has been no prior economic evaluation of ivosidenib.
12p
vishanshan
27-06-2024
2
1
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Ovarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all gynecological cancers. Glycosylation is a specific post-translational modification that plays an important role in tumor progression, immune escape and metastatic spread. The aim of this work was to identify the major glycosylation-related genes (GRGs) in OC and construct an effective GRGs signature to predict prognosis and immunotherapy.
16p
vikoch
27-06-2024
1
1
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In this work, the dispersion properties and nonlinear properties of circular photonic crystal fibers were improved by a combination of carbon tetrachloride infiltration into the core and modification of the air hole diameters d1 and d2 of rings in the cladding.
16p
viamancio
04-06-2024
1
0
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In recent years, the fourth industrial revolution has been progressing strongly, resulting in numerous accomplishments that have profound implications for various industries and sectors of the economy, including the banking sector. In the context of the digital transformation boom, traditional banking models have undergone modifications and advancements with the aim of boosting competitiveness and efficiency, leading to the emergence of the Open banking .
3p
zizaybay1101
09-05-2024
2
2
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Ebook "Fiber plants: Biology, biotechnology and applications" assesses the potential effects of biotechnological approaches, particularly genetic modification, on the present state of fiber crop cultivation and sustainable production. Leading international researchers discuss and explain how biotechnology can affect and solve problems in connection with fiber crops. The topics covered include biology, biotechnology, genomics and applications of fiber crops like cotton, flax, jute and bamboo.
263p
ladongphongthanh1008
22-04-2024
2
2
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Ebook "Ultrasound technology in dairy processing" provides an overview of the use of ultrasound in various dairy applications, highlighting their significant benefits for the dairy industry, including energy savings and product improvement. It describes in detail the physical and chemical effects of high- and low-frequency power ultrasound in specific applications such as emulsification, ultrafiltration, crystallisation, inactivation of microbes, functionality modifications of secondary dairy products and fat separation.
46p
tracanhphuonghoa1007
22-04-2024
7
3
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In the current paper, the effect of central and edge cracks, therefore, has been studied in jointed plates at mid-height of SPSW. Results indicated that the central crack is more destructive than the edge crack.
12p
viohoyo
25-04-2024
2
2
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In this study, the factors related to the veneer material and adhesive properties were fixed; however, working conditions and process parameters (impregnation, pre-drying, curing, gluing, hot press) could affect the performance of plywood. Therefore, the objective of this work is to investigate the influence of two different processes (with and without curing before gluing) on bonding quality of the treated beech plywood.
8p
vilarry
01-04-2024
9
1
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Previous studies have linked the Mediterranean diet (MED) with improved cardiometabolic health, showing preliminary evidence for a mediating role of the gut microbiome. We recently suggested the Green-Mediterranean (Green-MED) diet as an improved version of the healthy MED diet, with increased consumption of plant-based foods and reduced meat intake.
15p
viellison
28-03-2024
3
2
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Ebook "Tetramer stability and functional regulation of tumor suppressor protein p53" presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis.
82p
coduathanh1122
27-03-2024
1
1
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Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.
176p
cotieubac1004
15-03-2024
3
0
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The empirical literature on the effects of International Financial Reporting Standards (IFRS) adoption strategies on supply chain management and accounting quality focuses on more IFRS enforcement strategy. Limited studies have, in particular, examined IFRS modification strategy in relationship with accounting quality. In this regard, this paper investigates the impacts of different IFRS adoption strategies on accounting quality. The mediating effect of control of corruption on the relation between different IFRS adoption strategies on accounting quality is also examined.
9p
longtimenosee04
06-03-2024
2
0
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Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. Methods To capture existing knowledge on suppression relationships between human genes, we examined 2,400 published papers for potential interactions identified through either genetic modification of cultured human cells or through association studies in patients.
19p
vicwell
29-02-2024
4
1
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Ebook "Plant stress tolerance: Methods and protocols (Second edition)" provides up-to-date and new chapters covering the most important widely-used techniques in plant stress tolerance, including cutting-edge strategies, in a manner that ensures effective results. Plant Stress Tolerance: Methods and Protocols, Second Edition guides readers through reviews on epigenetics, long noncoding RNAs, and the influence of microbiome on drought tolerance.
354p
lucchinguyen
28-12-2023
6
2
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Many patients treated for breast cancer (BC) complain about cognitive difficulties affecting their daily lives. Recently, sleep disturbances and circadian rhythm disruptions have been brought to the fore as potential contributors to cognitive difficulties in patients with BC. Yet, studies on these factors as well as their neural correlates are scarce.
12p
vileonardodavinci
23-12-2023
4
3
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S-1 adjuvant chemotherapy is the standard treatment in Asia for resectable pancreatic ductal adenocarcinoma. The relative dose intensity of adjuvant chemotherapy influences survival in pancreatic cancer but does not precisely reflect treatment schedule modifications. We investigated the effects of total dose intensity of S-1 adjuvant chemotherapy on the survival of patients with pancreatic cancer and the permissible dose reduction.
9p
vialfrednobel
23-12-2023
7
3
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Part 2 book "Disease in wild animals, investigation and management" includes content: Disease management through manipulation of the host population, disease management through treatment and immunization, disease management through environmental modification, disease management through influencing human activities, emergency and integrated management programs, assessing the effectiveness of a disease-management program.
173p
oursky10
04-12-2023
7
2
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Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells. Specifically, a significant effect of histone acetylation modifications on the abnormal progression and microenvironment of diffuse large B-cell lymphoma (DLBCL) has been observed.
15p
visharma
20-10-2023
3
2
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This paper presents a solution to mitigate the influences of oscillations without the modification of the electric drives based on the utilization of the nonlinear control technique known as feedback linearization. The advantages of the proposed control method are low cost and straightforward to implement with the microcontroller unit. The effectiveness and robustness of this proposed control are verified through the analysis of simulation results and the comparison with PI control.
7p
giangnhanly
02-10-2023
5
3
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It is an established fact that the cause of Polycystic Ovarian Disease (PCOD) has a significant hereditary component. Various researchers have also revealed that PCOD is associated with obesity and successful weight reduction is the most effective method of restoring normal ovulation and menstruation. In the present study, an attempt is made to assess the general, anthropometric, biochemical and clinical observation along with lifestyle and dietary pattern of the patients.
6p
viisac
23-09-2023
5
1
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