Emerging avenues

Ebook "Models and algorithms for genome evolution" presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data.

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There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential to cost-efficiently accelerate precision medicine trials to improve clinical efficacy and diminish costs and toxicity. However, comprehensive ctDNA profiling in metastatic prostate cancer to date has been limited.

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Targeting deubiquitinases (DUBs) has emerged as a promising avenue for anticancer drug development. However, the effect and mechanism of pan-DUB inhibitor EOAI on non-small cell lung cancer (NSCLC) remains to be studied.

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The development of RNA sequencing (RNAseq) and the corresponding emergence of public datasets have created new avenues of transcriptional marker search. The long non-coding RNAs (lncRNAs) constitute an emerging class of transcripts with a potential for high tissue specificity and function.

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The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC).

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Protein kinases are a large family of druggable proteins that are genomi‑ cally and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the diferential response shown by altered kinases to drug treatment in patients and cell-based assays.

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Nanotechnology has recently emerged as an elementary discipline of science that explores the interaction of synthetic and biological materials. Nanotechnology is currently employed as a tool to exploit the darkest avenues of medical sciences to combat dreadful diseases caused by drug resistant microbes. Silver nanoparticles (Ag NPs) have been well known for its inhibitory and bactericidal effects. Silver Nanoparticles was synthesized by ecofriendly biogenic approach mediated by using the culture supernatant of Bacillus sp. DRI-6.

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In an emerging market, social development is an imperative, brands, consumers and society will benefited by cause-related marketing (CRM) that could provide an avenue to those in need receive more support than can be provided by traditional means. Though considerable work on CRM campaigns and consumer responses to them have been undertaken show ever, not much research has been done in this field in Nepal.

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Plants have evolved with a plethora of microorganisms having important roles for plant growth and health. A considerable amount of information is now available on the structure and dynamics of plant microbiota as well as on the functional capacities of isolated community members. Due to the interesting functional potential of plant microbiota as well as due to current challenges in crop production there is an urgent need to bring microbial innovations into practice. Different approaches for microbiome improvement exist.

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Anti-choice activists already succeeded in changing the legal standards for assessing restrictions on a woman’s right to choose; in Casey (1992), the court abandoned the most exacting standard of legal review applied to fundamental rights, “strict scrutiny,” and instead implemented the less protective standard of asking merely whether a restriction imposes an “undue burden” on a woman’s right to choose. 33 A second avenue of attack on Roe is to restrict or eliminate altogether its protections for women’s health.

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While current environmental challenges may sometimes seem insurmountable, they also represent opportunities for individuals, local communities and businesses and for international cooperation. New and exciting avenues to achieve sustainable development will emerge from the use of economic and regulatory instruments, new and existing technologies and the empowerment of stakeholders to establish enabling environments for innovation and creative solutions.

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The essential role of epidemiology is to improve the health of populations. Advances in epidemiology research are expected to play a central role in medicine and public health in the 21st century by providing information for disease prediction and prevention. This book represents an overview on the diverse threads of epidemiological research in that captures the new and exciting themes that have been emerging over recent years.

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