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Endoprotease activity
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Many small peptides regulate eukaryotic cell biology. In fungi, some of these peptides are produced after KEX2 protease activity on proteins displaying repetitions of identical or nearly identical motifs. Following this endoprotease activity, peptides are released in the extracellular space.
15p
vigiselle2711
30-08-2021
5
1
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Transglutaminase (TGase) fromStreptomyces mobaraensis is secreted as a precursor protein which is completely acti-vated by the endoprotease TAMEP, a member of the M4 protease family [Zotzel, J., Keller, P. & Fuchsbauer, H.-L. (2003) Eur. J. Biochem. 270, 3214–3222]. In contrast with the mature enzyme, TAMEP-activated TGase exhibits an additional N-terminal tetrapeptide (Phe-Arg-Ala-Pro) sug-gesting truncation, at least, by a second protease.
7p
tumor12
20-04-2013
49
1
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