Enhancer identification
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p vikoch 27-06-2024 3 1 Download
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- Over the years, the issue of talent shortage and undermanage of talent continues to stir challenges to many organizations both large and smaller firms. In most cases, SMEs constantly suffer from the shortage of talent due to various internal constraints, however, SMEs do aware of the importance of getting the right people for the key positions. Many of the respondents do recruit domain experts, although these employees are in the categories of lower-skilled workers.
9p longtimenosee10 26-04-2024 2 1 Download
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Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient populations and improve drug efficacy.
12p vibransone 28-03-2024 5 2 Download
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Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.
22p vibransone 28-03-2024 2 2 Download
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.
14p vioraclene 31-03-2024 3 2 Download
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This study aimed to develop and externally validate contrast-enhanced (CE) T1-weighted MRI-based radiomics for the identification of epidermal growth factor receptor (EGFR) mutation, exon-19 deletion and exon-21 L858R mutation from MR imaging of spinal bone metastasis from primary lung adenocarcinoma.
9p vialfrednobel 23-12-2023 7 4 Download
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High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening platforms used in the field of oncology are based solely on cancer cell populations and do not allow for the identification of immunomodulatory agents.
10p vischultz 20-10-2023 3 1 Download
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Continued part 1, part 2 of ebook "Platform embedded security technology revealed: Safeguarding the future of computing with Intel embedded security and management engine" provides readers with contents including: privacy at the next level: intel’s enhanced privacy identification (EPID) technology; boot with integrity, or don’t boot; trust computing, backed by the intel platform trust technology; unleashing premium entertainment with hardware-based content protection technology; breaking the boundaries with dynamically loaded applications;...
143p tieulangtran 28-09-2023 5 3 Download
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The incidence and prevalence of nontuberculous mycobacterial disease is increasing due to enhanced clinician awareness and improved detection methods. The species identification using molecular microbiology techniques allows a better understanding of the differences in pathogenicity and treatment response.
2p viintuit 26-09-2023 0 0 Download
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This article presents an improved procedure for detecting single damage in beam-like structures. Many damage detection methods are based on the analysis of beam natural frequency shifts in damaged and intact states and its analytical modal curvatures. They identify the damage by constructing curves of damage coefficients along the beam and visually determining the point of their mutual intersection.
15p viberkshire 09-08-2023 4 3 Download
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Using Failure Mode and Effects Analysis (FMEA) as an example quality improvement approach, our objective was to evaluate whether secondary use of orders, forms, and notes recorded by the electronic health record (EHR) during daily practice can enhance the accuracy of process maps used to guide improvement.
7p visteverogers 24-06-2023 4 2 Download
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Identification of genetic variants that are associated with fatty acid composition in beef will enhance our understanding of host genetic influence on the trait and also allow for more effective improvement of beef fatty acid profiles through genomic selection and marker-assisted diet management.
15p vinarcissa 21-03-2023 4 1 Download
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The focus of this study is on threshold concepts in the accounting discipline, in particular, to identify threshold concepts in the undergraduate accounting subject area of financial accounting, and to understand how and why threshold concepts are conceived and construed. An outcome of the identification and understanding of threshold concepts in financial accounting from this study is the potential to inform teaching and learning practices and approaches and in what ways they may contribute to enhancing the teaching and learning of undergraduate accounting students.
252p runthenight04 02-02-2023 2 1 Download
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The exploitation of novel alleles from wild rice that were lost during rice cultivation could be very important for rice breeding and evolutionary studies. Plant height (PH) was a target of artificial selection during rice domestication and is still a target of modern breeding.
12p vihagrid 30-01-2023 7 3 Download
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Hypoxia induced by flooding causes significant losses to crop production almost every year. However, the molecular network of submergence signaling pathway is still poorly understood. According to previous studies, transgenic plants overexpressing the WRKY33 gene showed enhanced resistance to submergence stress.
10p vihagrid 30-01-2023 5 3 Download
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The discovery of selection signatures has enabled the identification of genomics regions under selective pressure, enhancing knowledge of evolutionary genotype-phenotypes. Sex chromosomes play an important role in species formation and evolution. Therefore, the exploration of selection signatures on sex chromosomes has important biological significance.
10p vihagrid 30-01-2023 6 3 Download
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The obtained results confirm the accuracy, effectiveness, and reliability of the proposed approach in (1) alleviating the differences between measurement and simulation and (2) damage identification including damage location and severity, in the tested beam considering noise effects.
15p viaudi 29-08-2022 4 2 Download
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The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable.
11p viangelamerkel 27-07-2022 4 1 Download
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Whether during spontaneous breathing arterial pressure variations (APV) can detect a volume deficit is not established. We hypothesized that amplification of intra-thoracic pressure oscillations by breathing through resistors would enhance APV to allow identification of a reduced cardiac output (CO). This study tested that hypothesis in healthy volunteers exposed to central hypovolemia by head-up tilt.
8p viottohahn 30-03-2022 9 1 Download
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The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-genome sequencing of tumors can allow exhaustive identification of the specific structural variants present in an individual cancer, facilitating both clinical diagnostics and the discovery of novel mutagenic mechanisms.
15p vigalileogalilei 27-02-2022 10 1 Download