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Enhancer regulation
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Acute myeloid leukaemia (AML) is a fatal haematopoietic malignancy and is treated with the conventional combination of cytarabine (Ara-C) and daunorubicin (Dau). The survival rate of AML patients is lower due to the cardiotoxicity of daunorubicin.
12p
vishanshan
27-06-2024
1
1
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Emerging data suggested a favorable outcome in advanced non-small cell lung cancer (NSCLC) with chronic obstructive pulmonary disease (COPD) patients treated by immunotherapy. The objective of this study was to investigate the effectiveness of neoadjuvant immunotherapy among NSCLC with COPD versus NSCLC without COPD and explore the potential mechanistic links.
13p
vishanshan
27-06-2024
2
1
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Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation.
12p
vikoch
27-06-2024
1
1
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This article explores the evolving landscape of data protection law in Vietnam, focusing specifically on the responsibilities of data controllers under Vietnam's new Personal Data Protection Decree (Decree No. 13/2023/ND-CP - hereinafter referred to as Decree 13) and compares it with the European Union's General Data Protection Regulation (GDPR).
12p
viambani
18-06-2024
2
1
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Ebook Drugs in sport is the most comprehensive and accurate text on the emotive, complex and critical subject of doping and illegal performance enhancement in sport. Thoroughly updated in light of the latest World Anti-Doping Code and taking into account the latest regulations, methods and landmark cases, this seventh edition explores the science behind drug-use in sport, as well as its ethical, social, political and administrative context.
431p
vimeyers
29-05-2024
3
2
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The article "Legal framework enhancement for fintech development in Vietnam" is divided into four part including (i) The potential for Fintech development in Vietnam; (ii) The state of Fintech development in Vietnam; (iii) The current legal framework for the advancement of Fintech in Vietnam; (iv) Some proposals to improve the legal framework for Fintech development in Vietnam.
13p
dathienlang1012
03-05-2024
2
0
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The relevance is due to the variability and incompleteness of modern tax legislation, which results in increased attention to the problems of applying tax rules with the use of analogy as a key technique for overcoming legal lacunae. The objective is to enhance the development of the doctrinal frameworks for the practice of applying the analogy of law and to identify the peculiarities of the implementation of this tool in the area of tax.
10p
longtimenosee10
26-04-2024
3
1
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This study investigates the emotional responses of EFL student teachers to various affective situations during practicum and their coping strategies to enhance positive emotions and reduce negative emotions. Seventy female EFL student teachers participated in this study.
15p
viarnault
25-04-2024
1
1
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The light-emitting diodes (LEDs) have emerged as a sustainable illumination solution in the lighting industry. However, the commercial LEDs suffer from low chromatic rendition performance. This work proposes a feasible approach to enhance the quality of commercial LED packages via regulating scattering factors.
5p
viohoyo
25-04-2024
4
2
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The 2023 series of bank collapses has underscored the vital importance of effective liquidity risk management in the banking industry. Liquidity risk in bank, with its potential to trigger bank runs and destabilize the global financial system, requires a comprehensive approach that considers market volatility, regulatory changes, and evolving business models. Collaboration among banks, regulators, and stakeholders is crucial at the system level.
12p
longtimenosee09
08-04-2024
4
1
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The content of the article introduces the data protection regulations of some countries in the context of increasing cyberattacks and strengthening control and dominating information areas managed by those countries' laws. The article also reviews legal documents related to data protection in Vietnam and offers solutions for data protection that need to be enhanced in the process of developing digital libraries into smart digital libraries in Vietnam at present time.
13p
longtimenosee09
08-04-2024
0
0
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Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.
22p
vibransone
28-03-2024
2
2
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.
14p
vioraclene
31-03-2024
3
2
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Non-coding regulatory elements (NCREs), such as enhancers, play a crucial role in gene regulation, and genetic aberrations in NCREs can lead to human disease, including brain disorders. The human brain is a complex organ that is susceptible to numerous disorders.
27p
vibransone
28-03-2024
7
2
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The research "The impact of organizational culture, compensation on job satisfaction, and work motivation on school principal performance in Indonesia: Mediating role of supply chain practices" gives insight to the regulators that they expand their focus on the organizational culture along with the work motivation and job satisfaction that enhance the performance of the principal in the school.
9p
longtimenosee04
06-03-2024
3
0
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Part 1 book "Nursing leadership and management - Theories, processes and practice" includes contents: Leadership and followership, management theory, motivating yourself and others for a satisfying career, understanding organizational structures, legal and ethical knowledge for nurses, regulating nursing, economic influences, organizational communication, informatics, enhancing your critical thinking, decision making, and problem solving, nurses leading change.
205p
muasambanhan08
04-03-2024
3
1
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Ebook "Managing the prenatal environment to enhance livestock productivity" reviews phenotypic consequences of prenatal development, and provides details of mechanisms that underpin these effects in ruminants, pigs and poultry. The chapters have been divided into three parts: Quantification of prenatal effects on postnatal productivity, mechanistic bases of postnatal consequences of prenatal development and regulators of fetal and neonatal nutrient supply.
303p
tachieuhoa
28-01-2024
3
2
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Ebook "RNA activation" offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).
238p
lucchinguyen
28-12-2023
4
2
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Macrophage infiltration in the tumor microenvironment participates in the regulation of tumor progression. Previous studies have found that Notch signaling pathway is involved in regulating the progression of colorectal cancer (CRC), however, the specific mechanism is still unclear.
11p
vileonardodavinci
23-12-2023
6
3
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Despite today’s advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective targeted therapies against breast tumor types that do not respond to standard treatments. Therefore, identifying additional breast cancer molecular targets is urgently needed. Super-enhancers are large regions of open chromatin involved in the overactivation of oncogenes.
16p
vileonardodavinci
23-12-2023
8
3
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