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Enrichment scores
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Disagreements over genetic signatures associated with disease have been particularly prominent in the field of psychiatric genetics, creating a sharp divide between disease burdens attributed to common and rare variation, with study designs independently targeting each.
14p
vioraclene
31-03-2024
2
2
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We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations.
15p
vibransone
28-03-2024
2
1
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Biochemical recurrence (BCR) after initial treatment, such as radical prostatectomy, is the most frequently adopted prognostic factor for patients who suffer from prostate cancer (PCa). In this study, we aimed to construct a prognostic model consisting of gene expression profiles to predict BCR-free survival.
11p
viangelamerkel
27-07-2022
6
3
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Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372 heritable phenotypes measured in 361,194 UK Biobank individuals. Horizontal pleiotropy is pervasive throughout the human genome, prominent among highly polygenic phenotypes, and enriched in active regulatory regions.
18p
vielonmusk
30-01-2022
7
0
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The candy prepared from Ginger extract (10 ml/lit) treatment retained maximum amount of ascorbic acid, and non-reducing sugar and appreciable amount of acidity, reducing sugars, total sugars, and total phenol and observed minimum changes in total soluble solids than rest of the treatments and their increasing trend with advancement of storage period upto 180 days was recorded under ambient condition. On the other hand, candy prepared from Ginger extract (10 ml/lit) had low browning (0.11 OD) and highest organoleptic (8.
15p
chauchaungayxua10
19-03-2021
14
1
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New technologies for analyzing biological samples, like next generation sequencing, are producing a growing amount of data together with quality scores. Moreover, software tools (e.g., for mapping sequence reads), calculating transcription factor binding probabilities, estimating epigenetic modification enriched regions or determining single nucleotide polymorphism increase this amount of position-specific DNA-related data even further.
9p
vikentucky2711
26-11-2020
12
1
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Handling the vast amount of gene expression data generated by genome-wide transcriptional profiling techniques is a challenging task, demanding an informed combination of pre-processing, filtering and analysis methods if meaningful biological conclusions are to be drawn.
10p
vikentucky2711
26-11-2020
13
3
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The statistical evaluation of pathway enrichment, i.e. of gene profiles' confluence to the pathway level, allows exploring molecular landscapes using functionally annotated gene sets. However, pathway scores can also be used as predictive features in machine learning.
10p
vioklahoma2711
19-11-2020
10
1
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Gene set scoring provides a useful approach for quantifying concordance between sample transcriptomes and selected molecular signatures. Most methods use information from all samples to score an individual sample, leading to unstable scores in small data sets and introducing biases from sample composition (e.g. varying numbers of samples for different cancer subtypes).
10p
vicoachella2711
27-10-2020
8
1
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Current methods for gene-set or pathway analysis are usually designed to test the enrichment of a single gene-set. Once the analysis is carried out for each of the sets under study, a list of significant sets can be obtained.
10p
viconnecticut2711
28-10-2020
11
1
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Gene Set Enrichment Analysis (GSEA) is a powerful tool to identify enriched functional categories of informative biomarkers. Canonical GSEA takes one-dimensional feature scores derived from the data of one platform as inputs.
22p
vicoachella2711
27-10-2020
31
1
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Set enrichment methods are commonly used to analyze high-dimensional molecular data and gain biological insight into molecular or clinical phenotypes. One important category of analysis methods employs an enrichment score, which is created from ranked univariate correlations between phenotype and each molecular attribute.
13p
vijisoo2711
27-10-2020
12
1
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NanoString’s Prosigna™ Breast Cancer Prognostic Gene Signature Assay is based on the PAM50 gene expression signature. The test outputs a risk of recurrence (ROR) score, risk category, and intrinsic subtype (Luminal A/B, HER2-enriched, Basal-like).
14p
virose2711
25-09-2020
17
1
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Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its spread. Diagnostic strategies that comprehensively assess the functional complexity of tumor immune infiltrates could have wide-reaching clinical value.
17p
vimale2711
25-08-2020
11
2
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Fit and fine health is an asset in modern world. A diet sufficient in quantity as well as quality is required for a good health. Macro and micronutrient deficiencies, inadequate nutritional awareness affect the lives of western nation less dramatically than those are the citizen of developing countries. The grave situation by overpopulation and underproduction of food on international level is well documented.
5p
nguaconbaynhay6
23-06-2020
8
3
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Enriched shrikhand was prepared by blending WPC at 3, 4, 5 and 6 per cent levels and Maximum overall acceptability score of 8.20 was awarded to the sample prepared by using WPC at 5 per cent level and the sample was subjected to microwave treatment. There was a significant decrease in the per cent of moisture content of T3 sample (38.73%) compared to control (41.53%).
12p
nguathienthan4
21-04-2020
16
1
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This study aimed at standardization of plain and probiotic fruit yoghurt by blending with fruits such as banana, papaya, sapota at a ratio of 5%, 10% and 15%. Among the different fruits used banana, sapota incorporated fruit pulp secured higher sensory scores whereas papaya Plain probiotic yoghurt was prepared using three different probiotic cultures such as Lactobacillus plantarum NCDC 25, Lactobacillus casei NCDC 298, Lactobacillus rhamnosus, NCDC 19 along with yoghurt culture.
11p
quenchua4
06-04-2020
17
0
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The dynamism of fashion industry has forced retailers to desire low cost, versatility, flexibility and quality in design and speed to market. Highly competitive fashion market constantly needs to „refresh‟ product ranges which led to the appearance of small collections of merchandise. The rich traditional heritage, across the length and width of our country, offers diverse inspiration to the textile designers today.
10p
cothumenhmong3
22-02-2020
13
0
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Wheatgrass at young green stage is a powerhouse of nutrients and phytochemicals. With an aim to develop wheatgrass enriched health foods, Wheatgrass juice (WGJ) and wheatgrass powder (WGP) were incorporated in milk and meat products, respectively. WGJ (1:2 ratio of wheatgrass: water) was incorporated at 3, 6 and 9% in milk to formulate green milk, green paneer and enrobe paneer. WGP was incorporated at 1, 2 and 3% for chicken balls and nuggets. Overall acceptability score of green milk and green paneer with 9% WGJ was 8.15, 7.93 and 8.
10p
nguaconbaynhay3
07-02-2020
11
1
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This paper presents the first probabilistic parsing results for French, using the recently released French Treebank. We start with an unlexicalized PCFG as a baseline model, which is enriched to the level of Collins’ Model 2 by adding lexicalization and subcategorization. The lexicalized sister-head model and a bigram model are also tested, to deal with the flatness of the French Treebank. The bigram model achieves the best performance: 81% constituency F-score and 84% dependency accuracy.
8p
bunbo_1
17-04-2013
40
2
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