Entering clinical trials
-
Ebook "Medical foods from natural sources" fills the gap in the literature by discussing the history of enteral nutrition; interpreting the statistics regarding worldwide need for enteral nutrition support and cost involved; enumerating the processing technology to develop natural ingredients-based enteral foods; and describing the results of prospective clinical trials and case studies conducted to evaluate the effectiveness of enteral foods based on natural ingredients.
224p manmanthanhla0201 26-02-2024 6 1 Download
-
To assess usability and usefulness of a machine learning-based order recommender system applied to simulated clinical cases. Materials and Methods: 43 physicians entered orders for 5 simulated clinical cases using a clinical order entry interface with or without access to a previously developed automated order recommender system.
10p vighostrider 25-05-2023 5 2 Download
-
Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome.
7p viottohahn 30-03-2022 14 1 Download
-
Anti-CD3 immunotherapy was initially approved for clinical use for renal transplantation rejection prevention. Subsequently, new generations of anti-CD3 antibodies have entered clinical trials for a broader spectrum of therapeutic applications, including cancer and autoimmune diseases.
14p visilicon2711 20-08-2021 11 1 Download
-
Gene expression signatures for the prediction of differential survival of patients undergoing anti-cancer therapies are of great interest because they can be used to prospectively stratify patients entering new clinical trials, or to determine optimal treatment for patients in more routine clinical settings.
27p vicolorado2711 22-10-2020 11 0 Download
-
A substantial number of breast cancer patients are identified as being at high risk of developing metastatic disease. With increasing number of targeted therapeutics entering clinical trials, chronic administration of these agents may be a feasible approach for the prevention of metastases within this subgroup of patients.
9p vijisoo2711 29-09-2020 8 1 Download
-
Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy including an open-label, randomized controlled trial (RCT) comparing eLVT to phenobarbital.
12p vidublin2711 13-01-2020 26 1 Download
-
In this work, we further enhance our computational framework for breast cancer drug repurposing by visualizing the prospected dynamic gene expression after the treatment. Practically, the most challenging problem in drug repurposing is to prioritize the list of drugs for further in vivo validation and entering clinical trials.
13p vixyliton2711 17-04-2019 13 1 Download
-
Small molecules that activate the transcriptional function of wild type p53 have proved active as anti-cancer drugs in preclinical models and are now entering clinical trial. The complexity of the upstream p53 signaling pathway offers many targets for the devel-opment of such activators and the action of Mdm2 inhibitors, kinase inhibitors, sirtuin inhibitors and low doses of actinomycin D will be described among other examples.
3p viettel02 22-02-2013 39 2 Download
-
THE ESSENCE OF THE GUIDELINES presented here—start with your reports, enter the data directly into the computer, validate on entry, and monitor your results continuously—first appeared in a newsletter I edited in the mid-1980s.The reactions of readers then ranged from tepid to outwardly hostile:“We can’t afford to give every physician a computer,” raged one data manager, ignoring the $10,000 per patient that is the normal minimal expense for clinical data.
257p ozon_ozon 02-05-2012 61 8 Download