Enzyme channels

Hypertension is associated with the risk of prostate cancer (PCa) and its progression, however, it remains unclear whether antihypertensive medicines alter PCa risk or prognosis. This systematic review evaluated the role of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors in the risk and prognosis of PCa. This review was performed in line with PRISMA 2020 guidelines.

11p vishanshan 27-06-2024 2 1   Download

Part 1 book "Cardiac drug therapy" includes content: Beta blockers: The cornerstone of cardiac drug therapy - beta blocker controversies, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, ACE inhibitor ARB controversies, calcium antagonists (calcium channel blockers). calcium antagonist controversies, diuretics, hypertension, hypertension controversies.

336p zizaybay1101 30-04-2024 5 2   Download

Ebook "Marine toxins as research tools (Marine molecular biotechnology, Volume 46)" has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools.

268p manmanthanhla0201 26-02-2024 3 1   Download

Part 1 book "Biochemistry" includes content: Biochemistry - an evolving science, protein composition and structure, exploring proteins and proteomes, DNA, RNA and the flow of genetic information, exploring genes and genomes, exploring evolution and bioinformatics, hemoglobin - portrait of a protein in action, enzymes - basic concepts and kinetics, catalytic strategies, regulatory strategies, carbohydrates, lipids and cell membranes, membrane channels and pumps, signal transduction pathways.

455p oursky07 24-10-2023 10 4   Download

Glucose oxidase was covalently immobilized to a porous electrode, which was developed by using ferrocene functionalized polyethyleneimine, multiwall carbon nanotubes, and carbon cloth for biofuel cell applications in our recent studies. The kinetics parameters (i.e. kM, Vmax) and other parameters required for the modeling study were determined experimentally. Fuel cell flow channel geometry was analyzed by a computational fluid dynamics modeling approach. Substrate flow rate and mass transfer for each proposed channel type were considered in the simulations.

17p tudichquannguyet 29-11-2021 5 1   Download

Enzyme active sites can be connected to the exterior environment by one or more channels passing through the protein. Despite our current knowledge of enzyme structure and function, surprisingly little is known about how often channels are present or about any structural features such channels may have in common.

8p vikentucky2711 26-11-2020 7 1   Download

UDP-glucose pyrophosphorylase (UGPase) is a sugar-metabolizing enzyme (E.C. 2.7.7.9) that catalyzes a reversible reaction of UDP-glucose and pyrophosphate from glucose-1-phosphate and UTP. UDP-glucose is a key intermediate sugar that is channeled to multiple metabolic pathways.

14p viminato2711 22-05-2020 15 2   Download

Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting.

13p trinhthamhodang1 14-11-2019 19 3   Download

It is time to shift the arachidonic acid (ARA) paradigm from a harm-generating molecule to its status of polyunsaturated fatty acid essential for normal health. ARA is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. Arachidonic acid is obtained from food or by desaturation and chain elongation of the plant-rich essential fatty acid, linoleic acid.

9p trinhthamhodang1 14-11-2019 22 0   Download

The active site is located in a channel at the interface region between the H and L subunits, and the electron density in this part of the molecule suggests that the co-factor of this enzyme is not pyrrolo quinoline quinone (PQQ) itself, but might be instead a precursor of PQQ.

8p byphasse043256 12-01-2019 17 2   Download

The increasing awareness of the importance of chirality in the context of biological activity has stimulated a growing demand for efficient methods for industrial synthesis of pure enantiomers including chiral antiinflammatory drugs such as naproxen (Xin et al., 2001) and ibuprofen (Lee et al., 1995; Ducret et al., 1998; Xie et al., 1998; Arroyo et al., 1999; Chen and Tsai, 2000); antihypertensive agents such as angiotensin-converting enzyme (ACE) inhibitors (e.g., captopril, enalapril, ceranopril, zofenapril, and lisinopril); and the calcium channel- blocking drugs such as diltiazem.

109p loixinloi 08-05-2013 53 4   Download

The function of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was studied by labelling critical cysteine residues of the enzyme, either native or inserted by sitedirected mutagenesis, with different thiol-reacting molecules. The access of the substrate to the active centre cavity through a nonpolar channel that contains a narrow constriction harbouring a cysteine residue (C435) was probed by labelling experiments on both a C435S mutant, lacking C435 of the channel constriction, and a C25S/C50S/C455S/C537S mutant, bearing C435 as the only cysteine residue.

9p research12 01-06-2013 41 2   Download

Metabolite channelling, the process in which consecutive enzymes have confined substrate transfer in metabolic pathways, has been proposed as a biochemical mechanism that has evolved because it enhances catalytic rates and protects unstable intermediates. Results from experiments on the synthesis of radioactive urea [Cheung, C., Cohen, N.S. & Raijman, L (1989)J. Biol. Chem.264, 4038–4044] have been interpreted as implying channelling of arginine between argininosuccinate lyase and arginase in permeabi-lized hepatocytes. ...

9p tumor12 20-04-2013 34 1   Download

Pi4 is a38-residue toxincross-linkedby fourdisulfidebridges that has been isolated from the venom of the Chactidae scorpion Pandinus imperator. Together with maurotoxin, Pi1, Pi7 andHsTx1, Pi4belongs to theaKTX6 subfamilyof short four-disulfide-bridged scorpion toxins acting on K + channels. Due to its very low abundance in venom, Pi4 was chemically synthesized in order to better characterize its pharmacology and structural properties.

10p tumor12 20-04-2013 30 1   Download

A pathway intermediate is said to be ‘channeled’ when an intermediate just made in a pathway has a higher probability of being a substrate for the next pathway enzyme compared with a molecule of the same species from the aqueous cytoplasm. Channeling is an important phenomenon because it might play a significant role in the regulation of metabolism.

10p awards 06-04-2013 44 2   Download

The haem-distal pocket of nitric oxide reductase cyto-chrome P450 contains many Arg and Lys residues that are clustered to form a putative access channel for NADH. Asp88 is the sole negatively charged amino acid in this positive charge cluster, and thus it would be interesting to know its functional role.

8p dell39 03-04-2013 36 3   Download

What is ‘biochemical pharmacology’? • A fancy way of saying ‘pharmacology’, and of hiding the fact that we are sneaking a subject of medical interest into the UW biochemistry curriculum. • An indication that we are not going to discuss prescriptions for your grandmother’s aching knee; we will focus on the scientific side of things but not on whether to take the small blue pill before or after the meal. What is it not? • A claim that we accurately understand the mechanism of action of each practically useful drug in biochemical terms.

0p mnemosyne75 02-02-2013 55 2   Download

Thuốc Beta-Blockers Trị Cao Huyết Áp Trong báo Jl Family Practice tháng giêng 2008 có một bài của 2 bác sĩ Srah-Anne Schumann và John Hickner, thuộc Đại Học Y Khoa Chicago, nói về người già dùng thuốc beta-blockers trị cao máu. Trong tường trình có nhắc lại hướng dẫn JNC 7 khuyến cáo bệnh nhân uống thuốc lợi tiểu trước nhất và, nếu cần sau đó, dùng thêm những thuốc trị cao huyết áp beta-blockers, calcium-channel blockers, angiotensinconverting enzyme inhibitors, và angiotensin receptor blockers. Nghiên cứu Cochrane 2007 so sánh dùng thuốc trị cao máu betablockers cho bệnh nhân từ...

3p sinhtobo111 13-04-2011 104 3   Download

Một trong các cơ chế khu trú trao đổi chất phổ biến nhất là sự chia khoang (compartmentation) nghĩa là sự phân bố biệt hoá các enzyme và các chất trao đổi trong các cấu trúc tế bào tách biệt hoặc các bào quan có màng bao bọc. Chẳng hạn, sự oxy hoá acid béo gặp bên trong ti thể nhưng tổng hợp acid béo lại diễn ra trong tế bào chất.

8p heoxinhkute7 21-12-2010 71 2   Download