Epidemiology of Stone Formation

(BQ) How does this matter relate to the thirteenth edition of Williams Textbook of Endocrinology? Elsevier is the publisher of both The Lancet and Williams. The events described above were playing out in the summer and fall of 2014 at a time when preparations for the thirteenth edition were at an advanced stage, with commitments from editors and authors to complete this comprehensive endocrine text in a timely manner.

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An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia.

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