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Epitope prediction
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Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, generated in vitro and therefore lacking information about antigen processing.
15p
vibransone
28-03-2024
4
1
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p
vicwell
29-02-2024
2
1
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Part 1 book "Vaccine design, methods and protocols (Vol 2 - Vaccines for veterinary diseases)" includes content: Challenges in veterinary vaccine development and immunization, development of mycoplasma hyopneumoniae recombinant vaccines, computational prediction of immunodominant epitopes on outer membrane protein (OPM) H of pasteurella multocida toward designing of a peptide vaccine; DNA vaccines against maedi–visna virus, detection of avian antigen specific T-cells induced by viral vaccines,.... and other contents.
445p
oursky05
20-09-2023
0
0
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To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic drugs (DMARDs) in early RA, which is an unmet need in developing countries.
9p
vioregon2711
22-02-2021
8
1
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CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by MHC class II proteins. The ability to account for MHC class II polymorphism is critical for epitope-based vaccine design tools, as different allelic variants can have different peptide repertoires.
11p
viwyoming2711
16-12-2020
20
1
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We previously introduced PCPS (Proteasome Cleavage Prediction Server), a web-based tool to predict proteasome cleavage sites using n-grams. Here, we evaluated the ability of PCPS immunoproteasome cleavage model to discriminate CD8+ T cell epitopes.
11p
viwyoming2711
16-12-2020
6
1
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Recent efforts in HIV-1 vaccine design have focused on immunogens that evoke potent neutralizing antibody responses to a broad spectrum of viruses circulating worldwide. However, the development of effective vaccines will depend on the identification and characterization of the neutralizing antibodies and their epitopes.
15p
vikentucky2711
26-11-2020
13
1
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It is important to accurately determine the performance of peptide:MHC binding predictions, as this enables users to compare and choose between different prediction methods and provides estimates of the expected error rate.
9p
vikentucky2711
26-11-2020
7
0
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One of the major challenges in the field of vaccine design is identifying B-cell epitopes in continuously evolving viruses. Various tools have been developed to predict linear or conformational epitopes, each relying on different physicochemical properties and adopting distinct search strategies.
15p
vikentucky2711
26-11-2020
16
1
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B-cell epitopes have been studied extensively due to their immunological applications, such as peptide-based vaccine development, antibody production, and disease diagnosis and therapy. Despite several decades of research, the accurate prediction of linear B-cell epitopes has remained a challenging task.
6p
vikentucky2711
26-11-2020
5
0
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T cell epitope prediction tools and associated vaccine design algorithms have accelerated the development of vaccines for humans. Predictive tools for swine and other food animals are not as well developed, primarily because the data required to develop the tools are lacking.
11p
vikentucky2711
24-11-2020
9
3
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Predictions of MHC binding affinity are commonly used in immunoinformatics for T cell epitope prediction. There are multiple available methods, some of which provide web access. However there is currently no convenient way to access the results from multiple methods at the same time or to execute predictions for an entire proteome at once.
6p
vikentucky2711
24-11-2020
7
1
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The identification of immunogenic regions on the surface of antigens, which are able to be recognized by antibodies and to trigger an immune response, is a major challenge for the design of new and effective vaccines. The prediction of such regions through computational immunology techniques is a challenging goal, which will ultimately lead to a drastic limitation of the experimental tests required to validate their efficiency.
12p
vioklahoma2711
19-11-2020
12
2
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Computational scanning of peptide candidates that bind to a specific major histocompatibility complex (MHC) can speed up the peptide-based vaccine development process and therefore various methods are being actively developed.
9p
viconnecticut2711
29-10-2020
42
0
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Computational methods provide approaches to identify epitopes in protein Ags to help characterizing potential biomarkers identified by high-throughput genomic or proteomic experiments. PEPOP version 1.0 was developed as an antigenic or immunogenic peptide prediction tool.
17p
vicolorado2711
23-10-2020
10
0
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Leptospirosis, a zoonosis caused by Leptospira, is recognized as an emergent infectious disease. In currently, the lack of adequate diagnostic tools, vaccines are an attractive intervention strategy. In this experiment, a 550 bp fragment of large ribosomal RNA gene (16S rRNA) was sequenced and constructed phylogenetic tree from a panel of six Vietnamese pathogenic strains of Leptospira spirochetes (e.g., Pomona, Canicola, Mitis, Ictero haemohagiae, Bataviae, and Grippotyphosa).
12p
nguyenxuankha_bevandan
14-08-2020
10
1
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Canine parvovirus is the major cause of haemorrhagic gastroenteritis in canines worldwide. There is a high morbidity and mortality in the young puppies. The currently available CPV vaccine is protecting from all antigenic strains but still there is vaccination failure as the strains are emerging at higher rate.
6p
angicungduoc6
22-07-2020
7
1
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Cancer immunotherapy with immune checkpoint blockade (CKB) is now standard of care for multiple cancers. The clinical response to CKB is associated with T cell immunity targeting cancer-induced mutations that generate novel HLA-binding epitopes (neoepitopes).
10p
viputrajaya2711
22-06-2020
9
0
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Edwardsiella tarda is a Gram negative bacterium with a wide host range, mainly affecting fishes. It is a dreaded pathogen of cat fish culture. The presence of large number of serotypes of the pathogen makes the vaccine production against the pathogen a difficult task. Here in this study the suitability of outer membrane protein W (OMP W) as a vaccine candidate against E. tarda was investigated.
12p
trinhthamhodang1212
06-04-2020
10
1
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Peste-des-petits Ruminants (PPR) is a disease of small ruminants especially goat and its control and eradication till 2030 wants an extensive research to develop a potent vaccine. The role of surface HN protein in the attachment of the virus to cellular receptors makes it an appropriate target to develop a theranostics against the virus. In this study, cytotoxic T cells epitopes that will bind to MHC class I alleles were predicted out using bioinformatic tools.
8p
trinhthamhodang1212
06-04-2020
11
0
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