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Essential mediator
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Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.
14p
vikoch
27-06-2024
1
1
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Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.
1368p
vimeyers
29-05-2024
5
2
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The study is carried out with an objective to explore the impact of green supply chain management on different performance measures such as environmental performance, operational performance and financial performance. In addition to that, the mediating role of operational performance and the environmental performance in the relationship between green supply chain management and the financial performance is also examined.
11p
longtimenosee10
26-04-2024
2
1
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Ebook "Carbohydrate-based interactions at the molecular and the cellular level" offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions.
216p
tracanhphuonghoa1007
22-04-2024
4
3
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p
vibransone
28-03-2024
6
2
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The financial along with financial, environmental and operational performance is the essential part of organizational success and economic growth while green supply chain management is considered as the essential element for the financial, environmental and operational performance. Thus, the present study has examined the green supply chain management impact on the financial, environmental and operational performance of the manufacturing organization in Indonesia.
8p
longtimenosee06
27-03-2024
4
2
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The work productivity has played an essential role in the success of the organization and also enhance the economic growth and supply chain practices is considered as the essential element to improve the work productivity and also gain the attention of well-known researchers. Thus, the present study has examined that impact of the workplace environment, supply chain performance and supply chain integration on the work productivity of the banks in Indonesia.
8p
longtimenosee06
27-03-2024
2
2
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Common and rare variants contribute to the etiology of complex traits. However, the extent to which the phenotypic effects of common and rare variants involve shared molecular mediators remains poorly understood. The question is essential to the basic and translational goals of the science of genomics, with critical basic-science, methodological, and clinical consequences.
13p
vicwell
29-02-2024
4
2
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Ebook "RNA activation" offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).
238p
lucchinguyen
28-12-2023
4
2
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Liver cancer is the third most deadly malignant tumor in the world with poor prognosis and lacks early diagnostic markers. It is urgent need to explore new biomarkers and prognostic factors. The oxysterol-binding protein-like family proteins (OSBPLs) are essential mediators of lipid transportation and cholesterol balancing which has been reported to participate in cancer progression.
11p
vischultz
20-10-2023
3
1
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Proper phosphate signaling is essential for robust growth of Escherichia coli and many other bacteria. The phosphate signal is mediated by a classic two component signal system composed of PhoR and PhoB.
11p
vinarcissa
21-03-2023
2
1
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Heading time is an important adaptive trait in durum wheat. In hexaploid wheat, Photoperiod-1 (Ppd) loci are essential regulators of heading time, with Ppd-B1 conferring photoperiod insensitivity through copy number variations (CNV).
8p
vihagrid
30-01-2023
6
3
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Myeloproliferative neoplasm is a group of blood cancers, including three main diseases: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera. Several molecular signaling pathways such as JAK/STAT, PI3K or SHP have been demonstrated that play a crucial role in controlling the signaling-mediated immune response related to Myeloproliferative neoplasms.
6p
vimelindagates
18-07-2022
4
2
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Sensory processing is essential for the interaction with the environment and for adequate daily function. Sensory processing may deteriorate with aging and restrict daily activity performance. Aging may also affect Executive functions (EFs) which are critical for daily activity performance.
10p
viisaacnewton
25-04-2022
17
4
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Buffalo milk is rich in various nutritional components and bioactive substances that provide more essential health benefits to human body. Recently, exosome identified in the breast milk has been reported as a neotype nutrient and can mediate intercellular communication with exosomal miRNAs.
5p
vigalileogalilei
28-02-2022
7
1
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Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Here, we characterize the inosinome signature in normal brain and de novo glioblastoma (GBM) using new metrics that re-stratify GBM patients according to their editing profiles and indicate this post-transcriptional event as a possible molecular mechanism for sexual dimorphism in GBM.
18p
vigalileogalilei
27-02-2022
10
1
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Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein recoding is the essential function of ADAR2, but an essential role for recoding by ADAR1 has not been demonstrated.
18p
vialfrednobel
29-01-2022
8
0
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The IL23/Th17 pathway is essential for the onset of inflammatory bowel disease (IBD), yet the specific mechanism by which this pathway initiates the disease remains unknown. In this study, we identify the mechanisms that mediate cross-talk between the IL23 pathway and the intestinal barrier in IBD.
15p
viaristotle
29-01-2022
7
1
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Soluble protein and lipid mediators play essential roles in the tumor environment, but their cellular origins, targets, and clinical relevance are only partially known. We have addressed this question for the most abundant cell types in human ovarian carcinoma ascites, namely tumor cells and tumor-associated macrophages.
22p
viaristotle
29-01-2022
4
0
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Polycomb repressive complex 1 (PRC1) and PRC2 are chromatin regulators maintaining transcriptional repression. The deposition of H3 lysine 27 trimethylation (H3K27me3) by PRC2 is known to be required for transcriptional repression, whereas the contribution of H2A ubiquitination (H2Aub) in the Polycomb repressive system remains unclear in plants.
21p
viarchimedes
26-01-2022
6
0
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