Essential protein

Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.

17p vikoch 27-06-2024 3 1   Download

Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and BRAF V600E mutations. This makes pLGG an ideal candidate for MAPK pathway-targeted treatments.

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Ebook "Lipids in photosynthesis: Essential and regulatory functions" provides an essential summary of an exciting decade of research on relationships between lipids and photosynthesis. The book brings together extensively cross-referenced and peer-reviewed chapters by prominent researchers. The topics covered include the structure, molecular organization and biosynthesis of fatty acids, glycerolipids and nonglycerolipids in plants, algae, lichens, mosses, and cyanobacteria, as well as in chloroplasts and mitochondria.

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Ebook "Membrane proteins production for structural analysis" updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.

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Ebook "VEGF in development" is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit.

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Ebook "The role of water in ATP hydrolysis energy transduction by protein machinery" introduces recent progress in biological energetics from ATP hydrolysis to molecular machineries. The role of water is now recognized to be essential in biological molecular energetics. Although energetics is a rather distant field to many biologists, any working models for protein machineries such as protein motors, transporters, and other enzymes must be consistent with their energetics.

346p tracanhphuonghoa1007 22-04-2024 7 2   Download

Ebook "Carbohydrate-based interactions at the molecular and the cellular level" offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions.

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Ebook "Dynamic studies through control of relaxation in NMR spectroscopy" offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells.

118p tudohanhtau1006 29-03-2024 4 1   Download

Ebook "Molecular farming in plants: Recent advances and future prospects" with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

284p coduathanh1122 27-03-2024 6 1   Download

Ebook "NMR of proteins and small biomolecules" studying protein-ligand interactions with NMR techniques that have unique powers for the study of weak protein-ligand interactions, as described in chapter 2, followed by the use of residual dipolar coupling approaches, reviewed in chapter 3, may be essential.

255p coduathanh1122 27-03-2024 3 1   Download

Ebook "Protein-Protein interactions (Topics in Medicinal chemistry, Volume 8)" surveys the field of inhibitors of the MDM2/p53 interaction, which essentially began with the high-profile disclosure of Nutlins, and quickly and steadily grew through programs at a number of pharmaceutical companies. The MDM2/p53 interaction constitutes a paradigm example of a relatively large, hydrophobic interaction surface for which lead compounds can easily be found.

276p coduathanh1122 27-03-2024 5 1   Download

Ebook "SUMO regulation of cellular processes (Second edition)" of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

413p cotieubac1004 15-03-2024 1 0   Download

Part 1 book "Essential cell biology" includes content: Cells - The fundamental units of life, chemical components of cells energy, catalysis and biosynthesis, protein structure and function, DNA and chromosomes, DNA replication and repair, from DNA to protein - How cells read the genome, control of gene expression, how genes and genomes evolve, analyzing the structure and function of genes.

398p muasambanhan08 01-03-2024 2 1   Download

Part 2 book "Essential cell biology" includes content: Membrane structure, transport across cell membranes, how cells obtain energy from food, energy generation in mitochondria and chloroplasts, intracellular compartments and protein transport, cell signaling, cytoskeleton, the cell division cycle, sexual reproduction and genetics, cell communities: tissues, stem cells and cancer.

467p muasambanhan08 01-03-2024 3 1   Download

5’ untranslated regions (5’UTRs) are essential modulators of protein translation. Predicting the impact of 5’UTR variants is challenging and rarely performed in routine diagnostics. Here, we present a combined approach of a comprehensive prioritization strategy and functional assays to evaluate 5’UTR variation in two large cohorts of patients with inherited retinal diseases (IRDs).

21p vicwell 29-02-2024 3 1   Download

Ebook "Analytics of Protein–DNA interactions (Advances in biochemical engineering/biotechnology, Volume 104)" focuses on the fascinating possibilities that emerged during the last years to study protein–DNA interactions in vitro. As an essential part of transcriptional activity during development and in tumorgenesis a separate chapter describing the analysis of DNA modification especially methylation of cytosines at their carbon-5 position was included.

212p manmanthanhla0201 27-02-2024 4 2   Download

Ebook "Essentials of food science (Third edition)" is designed with a user-friendly approach to Food Science for the non-major. This text reviews an Introduction to Food Components – quality and water. Next it addresses carbohydrates – including starches, pectines and gums, breads and pasta, vegetables and fruits. Then proteins – meats, poultry, fish, beans, eggs, milk and milk products are presented. Following proteins are fats and emulsions. Then sugars and sweeteners, and baked products, the latter of which builds upon basic food component knowledge.

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Ebook "Sulfur assimilation and abiotic stress in plants" discusses the aspects of sustainable crop production with sulfur, the importance of sulfur metabolites and sulfur metabolizing enzymes in abiotic stress management in plants. Sulfur is one of the four major essential elements necessary for the plant life cycle. Its assimilation in higher plants and its reduction in metabolically important sulfur compounds are crucial factors determining plant growth and vigor and resistance to stresses.

373p tachieuhoa 28-01-2024 3 2   Download

Ebook "Microalgae biotechnology" presents an authoritative and comprehensive overview of the microalgae-based processes and products. Divided into 10 discreet chapters, the book covers topics on applied technology of microalgae. Microalgal Biotechnology provides an insight into future developments in each field and extensive bibliography. It will be an essential resource for researchers and academic and industry professionals in the microalgae biotechnology field.

205p lamquandat 28-12-2023 7 2   Download

Ebook "Cadmium: From toxicity to essentiality" provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area.

589p lucchinguyen 28-12-2023 5 2   Download