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Essential therapy
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Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it is vital to determine the prognostic value and therapy response of PCD-related genes in OC.
17p
vishanshan
27-06-2024
1
1
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KRAS is the undisputed champion of oncogenes, and despite its prominent role in oncogenesis as mutated gene, KRAS mutation appears infrequent in gliomas. Nevertheless, gliomas are considered KRAS-driven cancers due to its essential role in mouse malignant gliomagenesis. Glioblastoma is the most lethal primary brain tumor, often associated with disturbed RAS signaling.
11p
vishanshan
27-06-2024
1
1
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Evaluation of human epidermal growth factor receptor 2 (HER2) overexpression caused by erbb2 receptor tyrosine kinase 2 (ERBB2) amplification (AMP) by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) is essential for treating unresectable metastatic gastric cancer (GC).
13p
vikoch
27-06-2024
1
1
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Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.
14p
vikoch
27-06-2024
1
1
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p
vikoch
27-06-2024
3
1
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Ebook Pharmacotherapy handbook, tenth edition delivers the essential information students and practitioners need to quickly and confidently make drug therapy decisions for more than 140 of the diseases and disorders most commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.
1304p
vimeyers
29-05-2024
3
2
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Part 2 book "Essentials of nuclear medicine and molecular imaging" includes contents: Skeletal system, genitourinary system and adrenal glands, Non-PET neoplasm imaging and radionuclide therapy, hybrid PET/CT neoplasm imaging, inflammation and infection imaging, authorized user and radioisotope safety issues.
301p
dianmotminh01
14-05-2024
4
0
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p
vibransone
28-03-2024
6
2
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Colorectal cancer is the 2nd leading cause of cancer-related deaths with few patients benefiting from biomarker-guided therapy. Mutation expression is essential for accurate interpretation of mutations as biomarkers, but surprisingly, little has been done to analyze somatic cancer mutations on the expression level. We report a large-scale analysis of allele-specific mutation expression.
18p
vibransone
28-03-2024
2
2
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Using BRCA1 and BRCA2 variants, which have consequences on PARP inhibitor sensitivity, and POLE variants, potential biomarkers of immunotherapy response, we developed a rapid functional assay based on CRISPR-Cas9 genome editing to determine the functional consequences of these variants having potentially direct implications on patients’ access to targeted therapies.
14p
vibransone
28-03-2024
2
2
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Ebook "Stem cell therapy for diabetes" provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes. Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.
294p
cotieubac1004
15-03-2024
0
0
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Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen dep‑ rivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include evolution as an essential feature.
15p
vicwell
29-02-2024
2
2
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The BRCA2 gene is a well-known tumor suppressor gene implicated in breast and ovarian cancers. BRCA1/2 mutations can be sensitive to poly ADP-ribose polymerase (PARP) inhibitors such as olaparib. However, some of these patients develop resistance to this treatment and an essential factor contributing to acquired insensitivity is the occurrence of reversion mutations in the BRCA1/2 genes.
5p
vitiki
30-01-2024
4
2
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LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA m6A modification in hepatocellular carcinoma (HCC) and identify relative prognostic predictors to guide therapy and explore potential therapeutic targets. Pearson correlation analysis was performed to identify m6A-related lncRNAs in 374 patients with HCC.
18p
vimichaelfaraday
28-12-2023
3
3
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Brain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the treatment of these tumours, although the optimal radiation strategy remains controversial. The present study aimed to assess whether whole brain radiation therapy with a simultaneous integrated boost (WBRT + SIB) provides any therapeutic beneft over WBRT alone.
12p
vileonardodavinci
23-12-2023
6
3
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Carpal Tunnel Syndrome (CTS) is a common pathology that affects the quality of human life. It is essential to promote clinical intervention studies. Our initial step in this study focused on the cure for CTS and the safety of Laser Acupuncture (LA), which is a type of acupuncture uses low-level laser instead of metal acupuncture needles.
9p
vikissinger
21-12-2023
7
2
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Part 1 book "Essentials of small animal anesthesia and analgesia" includes content: Patient evaluation and risk management; anesthetic physiology and pharmacology; pain physiology, pharmacology, and management; chronic pain management; anesthesia equipment; patient monitoring; acid–base balance and fluid therapy; anesthesia management of dogs and cats; anesthesia and immobilization of small mammals.
355p
oursky10
04-12-2023
8
3
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Ebook Phytogenics in animal nutrition, natural concepts to optimize gut health and performance" includes content: Enhancing feed intake by the sow during lactation using biomin P.E.P.; phytogenic compounds in broiler nutrition; essential oils as feed additives in ruminant nutrition; the potential of phytogenic compounds in aquaculture; application and benefits of phytogenics in egg production.
96p
oursky07
24-10-2023
4
1
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Part 1 book "Phytogenics in animal nutrition - Natural concepts to optimize gut health and performance" includes content: Essential oils - biochemistry, production and utilisation; phytogenic feed additives to young piglets and poultry - mechanisms and application; influence of phytogenics on the immunity of livestock and poultry, phytobased products for the control of intestinal diseases in chickens in the post antibiotic era.
95p
oursky07
24-10-2023
4
1
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Colorectal cancer survivors often experience decline in physical performance and poor quality of life after surgery and during adjuvant therapies. In these patients, preserving skeletal muscle mass and high-quality nourishment are essential to reduce postoperative complications and improve quality of life and cancer-specific survival.
9p
vischultz
20-10-2023
2
1
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