Estimation of the model parameters

The estimation of the model parameters is performed by maximum likelihood method. We hope that the new distribution proposed here will serve as an alternative model to the other models which are available in the literature for modeling positive real data in many areas.

11p guineverehuynh 22-06-2020 12 0   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 13 1   Download

Construction of bounds on the elastic moduli of isotropic multicomponent materials which involve three-point correlation parameters. We use numerical methods to study several representative material models. Construction of three-point correlation bounds on the effective elastic shear modulus of composite materials and applications of the bounds are given to some composites.

31p change04 08-06-2016 39 4   Download

The glyoxalase pathway ofLeishmania infantumwas kinetically character-ized as a trypanothione-dependent system. Using time course analysis based on parameter fitting with a genetic algorithm, kinetic parameters were estimated for both enzymes, with trypanothione derived substrates. A Kmof 0.253 mmand aVof 0.21lmolÆmin )1 Æmg )1 for glyoxalase I, and a Kmof 0.098 mmand aVof 0.18lmolÆmin )1 Æmg )1 for glyoxalase II, were obtained.

11p awards 06-04-2013 46 2   Download

Experimental design has a long tradition in statistics, engineering and life sciences, dating back to the beginning of the last century when optimal designs for industrial and agricultural trials were considered. In cell biol-ogy, the use of mathematical modeling approaches raises new demands on experimental planning.

17p vinaphone15 27-02-2013 40 3   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects

0p toshiba19 15-11-2011 52 4   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis

0p toshiba19 15-11-2011 68 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Key transmission parameters of an institutional outbreak during the 1918 influenza pandemic estimated by mathematical modelling

7p toshiba17 28-10-2011 41 3   Download

1) Introduction The estimates of the regression parameters are influenced by a few extreme observations. The residual plot may let us pick out, which the individual data points are high or low. We may use the residual plot to find the outlier, which are inadequately captured by the regression model itself.

8p truongdoan 10-11-2009 103 7   Download