Evaluating clinical research

Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress. In vitro CTC clusters model can help to further understand the biological properties of CTC clusters and their clinical significance.

17p vishanshan 27-06-2024 1 1   Download

Patient education is a vital role of nurses in nurse-led clinics(NLCs). Since 2011, independent NLCs entitled health education Nurse-led clinics(HENLCs) have been established in Iran. In order for this newly developed service to be able to perform perfectly in implementation and evaluation, it should be explained based on one of the quality evaluation models.

12p vishanshan 27-06-2024 1 1   Download

The study emphasizes the importance of telehealth SLP services in meeting the increasing demand for mental health interventions among children and adolescents. It suggests integrating telehealth into clinical practice beyond the pandemic and highlights the need for long-term evaluation and addressing potential barriers to access.

8p vishanshan 27-06-2024 2 1   Download

Over the past few decades, the utilization of Artificial Intelligence (AI) has surged in popularity, and its application in the medical field is witnessing a global increase. Nevertheless, the implementation of AI-based healthcare solutions has been slow in developing nations like Pakistan. This unique study aims to assess the opinion of clinical specialists on the future replacement of AI, its associated benefits, and its drawbacks in form southern region of Pakistan.

11p vishanshan 27-06-2024 1 1   Download

The combination of antifungal drugs for the treatment of dermatophytosis, including oral itraconazole and topical terbinafine, has been shown to be more effective than monotherapy. To describe the clinical characteristics and evaluate the results of patients with dermatophytosis treated with the combination of oral itraconazole and topical terbinafine at Can Tho Hospital of Dermato-Venereology in 2023.

7p vikoch 27-06-2024 1 1   Download

Liver abscess is a common disease in tropical countries, including Vietnam. Nguyen Tri Phuong Hospital has treated many cases of liver abscesses since 2010. However, there has not been a research report summarizing the clinical and subclinical characteristics of liver abscess cases here.

9p vigeorge 06-12-2023 3 1   Download

The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based on patient reported data.

9p vischultz 20-10-2023 6 1   Download

Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are key in evaluating therapeutics prior clinical trials. In this editorial, we invite contributions for a BMC Cancer’s Collection of articles addressing ‘Advances in pre-clinical cancer models’ towards relivable outcomes at the preclinical stage.

3p vischultz 20-10-2023 3 1   Download

This study aims to evaluate the clinical efficacy and side effects of setting up a high-risk clinical target volume (CTV-hr) alongside simultaneous integrated boost intensity-modulated radiotherapy (IMRT-SIB) in patients diagnosed with stage IIB-IVA cervical cancer.

12p visharma 20-10-2023 2 2   Download

Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with platinum based chemotherapy and PD-1/PD-L1 directed immunotherapy.

11p vioracle 29-09-2023 2 2   Download

To create chimeric antigen receptor (CAR) T cells and evaluate the effect on CD19+ B cells in animal models of acute lymphoblastic leukemia. Methods: An experimental research (In vitro and In vivo) was conducted at the Department of Pathophysiology, Military Medical University, from June 2019 to 2022.

11p vipierre 29-09-2023 9 2   Download

To evaluate the analgesic effect of nano Berberin gel in the treatment of superficial burns. Subjective and Method: Study on 32 pediatric burn patients, treated at the Pediatric Burn Department in Le Huu Trac National Burn Hospital from 1 January 2022 to 30 April 2022.

11p vihulk 28-07-2023 3 3   Download

Survey to determine clinical manifestations, correlative factors and evaluate the results of topical treatment of herpes zoster with He-Ne laser combination at Can Tho DermatoVenereology Hospital in 2021. Methods: Cross-sectional descriptive study with 75 Zona patients who were treated according to the usual regimen and combined with local He-Ne laser at Can Tho Dermato-Venereology Hospital.

8p vistarlord 24-06-2023 7 2   Download

Phenotyping algorithms applied to electronic health record (EHR) data enable investigators to identify large cohorts for clinical and genomic research. Algorithm development is often iterative, depends on fallible investigator intuition, and is time- and labor-intensive.

10p visteverogers 24-06-2023 11 4   Download

The repurposing of electronic health records (EHRs) can improve clinical and genetic research for rare diseases. This paper presents a method to detect family history and negation in narrative reports and evaluates its impact on selecting populations from a clinical data warehouse (CDW).

7p visteverogers 24-06-2023 2 2   Download

The study sought to design, pilot, and evaluate a federated data completeness tracking system (CTX) for assessing completeness in research data extracted from electronic health record data across the Accessible Research Commons for Health (ARCH) Clinical Data Research Network.

9p visteverogers 24-06-2023 6 2   Download

To contribute a conceptual framework for evaluating data suitability to satisfy the research needs of observational studies. The suitability framework evaluates a clinical data source’s fitness for research use. Its construction reflects both researchers’ points of view and data custodians’ design features. The feedback from domain experts rated Usability, Relevance, and Quality categories as the most important considerations.

11p visteverogers 24-06-2023 2 2   Download

Randomized controlled trials (RCTs) are the gold standard method for evaluating whether a treatment works in health care but can be difficult to find and make use of. We describe the development and evaluation of a system to automatically find and categorize all new RCT reports.

10p vighostrider 25-05-2023 3 2   Download

To synthesize data quality (DQ) dimensions and assessment methods of real-world data, especially electronic health records, through a systematic scoping review and to assess the practice of DQ assessment in the national Patient-centered Clinical Research Network (PCORnet).

12p vighostrider 25-05-2023 5 2   Download

Accurate extraction of breast cancer patients’ phenotypes is important for clinical decision support and clinical research. This study developed and evaluated cancer domain pretrained CancerBERT models for extracting breast cancer phenotypes from clinical texts.

9p vighostrider 25-05-2023 2 2   Download