Evaluation on the efficacy

PPOS (Progestin-Primed Ovarian Stimulation) has shown efficacy in preventing early luteinization and improving outcomes in infertile women. However, data among those with poor ovarian response (POR) are limited. This study aimed to evaluate the effect of PPOS protocol on the chance of success throughout the IVF process in patients with POR (POSEIDON group III & IV) undergoing IVF/ICSI in Vietnam.

11p vikoch 27-06-2024 3 1   Download

The numbers of registered clinical trials show an upward trend. Age disparities between trial participants and diagnosed disease population are present in BPCRL cancer trials and appear to be increasing over time. Equitable participation in clinical trials on the basis of age is crucial for advancing medical knowledge and evaluating the safety and efficacy of new treatments that are generalizable to aging populations.

8p vishanshan 27-06-2024 2 1   Download

To explore challenges of liquid-based cytology (LBC) specimens for next-generation sequencing (NGS) in lung adenocarcinoma and evaluate the efficacy of targeted therapy. Methods A retrospective analysis was conducted on the NGS test of 357 cases of advanced lung adenocarcinoma LBC specimens and compared with results of histological specimens to assess the consistency. The impact of tumor cellularity on NGS test results was evaluated.

8p vikoch 27-06-2024 1 1   Download

Novel antibody-drug conjugates (ADCs) drugs present a promising anti-cancer treatment, although survival benefits for HER2-positive advanced breast cancer (BC) remain controversial. The aim of this meta-analysis was to evaluate the comparative effect of ADCs and other anti-HER2 therapy on progression-free survival (PFS) and overall survival (OS) for treatment of HER2-positive locally advanced or metastatic BC.

10p vikoch 27-06-2024 1 1   Download

The occurrence of surgical site infection (SSI) after pancreaticoduodenectomy (PD) is still relatively high. The aim of this retrospective study is to evaluate the efficacy of piperacillin-tazobactam as perioperative prophylactic antibiotic on organ/space SSI for patients underwent PD.

10p vikoch 27-06-2024 1 1   Download

As such, the current pilot study was conducted with two aims: Evaluating the safety and improving sleep efficiency of WBLX ear seeds acupressure followed NADA protocol in treating primary insomnia; Evaluating the efficiency in improving other self-reported symptoms caused by insomnia, including fatigue, decreased concentration, anxiety, decreased memory, and dizziness.

10p vilarry 12-03-2024 3 2   Download

Ebook "Retinal gene therapy: Methods and protocols" describes a spectrum of methods and protocols that can be used for the bench-to-bedside development and evaluation of retinal gene therapy. Methods for the successful delivery of these gene therapy vector systems to the retina are examined, as well as assays to test the efficacy in vitro in cell cultures, for gene augmentation and gene editing in vivo on rodents, pigs, and monkey retinas, and on human retinal explants as well as in human clinical studies.

373p lucchinguyen 28-12-2023 9 2   Download

Ebook "Characterization of nanoparticles intended for drug delivery (Second edition)" expands on the first edition by providing up-to-date protocols to characterize nanomaterials used as drug delivery agents. The chapters in this book are divided into 5 parts and cover topics such as: advances and obstacles in nanomedicine research; methods to test sterility and endotoxin, physicochemical features, immunological effects, drug release, and in vivo efficacy.

250p lucchinguyen 28-12-2023 3 2   Download

Nutritional support, including nutritional counseling and oral nutritional supplements (ONS), has been recommended as a first-line strategy in patients with non-small cell lung cancer (NSCLC). Evidence on the efficacy of immunonutrition during immunotherapy in these patients is positive, but still limited some secondary endpoints, such as treatment toxicity and tolerance.

10p vileonardodavinci 23-12-2023 4 2   Download

This study aimed to explore the efficiency and safety of the new generation antibody-drug conjugate Trastuzumab deruxtecan (DS-8201a) in treating HER2-positive solid cancers. By searching PubMed, Medline and Ovid for all clinical trials related to the safety and efficacy of DS-8201a. Event rates were calculated for all adverse events (AEs) to evaluate the safety of DS-8201a. Objective response rate (ORR) and progression-free survival (PFS) were summarized to assess the potency of DS-8201a.

9p vialfrednobel 23-12-2023 5 3   Download

Chemotherapy-induced peripheral neuropathy (CIPN) is a painful, dose-limiting adverse effect of commonly used chemotherapeutic agents. The purpose of this exploratory study was to evaluate the efficacy and safety of mirogabalin in patients with moderate to severe CIPN during chemotherapy and the effects of 12 weeks’ intervention on chemotherapy completion and CIPN severity.

11p vialfrednobel 23-12-2023 2 2   Download

Knee osteoarthritis (KOA) is one of the most common causes of chronic pain and disability. In addition, many studies have shown that laser acupuncture (LA) has a great analgesic effect and minimal side effects. This study aims to evaluate the efficacy and safety of LA combined with knee exercises (KE) in patients with KOA.

8p vikissinger 21-12-2023 2 2   Download

To evaluate the efficacy of botulinum toxin type A (BTA) injection in combination with rehabilitation on improving the dynamic spastic equinus foot in children with spastic cerebral palsy.

8p visoros 01-11-2023 3 1   Download

PRECONNECT was an international, phase IIIb trial evaluating the safety and efficacy of trifluridine/tipiracil (FTD/TPI) for metastatic colorectal cancer (mCRC). Patients with mCRC received FTD/TPI 35mg/m2 twice-daily on days 1–5 and 8–12 of each 28-day cycle for third- or later-line treatment.

11p vischultz 20-10-2023 7 1   Download

Programmed death-1 (PD-1) and its ligand (PD-L1) inhibitors have been reported in several clinical trials for gastric cancer and gastroesophageal junction cancer (GC/GEJC). We presently carried out a meta-analysis to evaluate the potency of PD-1/PD-L1 inhibitors in advanced GC/GEJC individuals with different clinical features and to determine patients more probably benefitting from the treatment.

16p vischultz 20-10-2023 3 2   Download

In this study we aimed to evaluate the efficacy and safety of the PD-L1 inhibitor durvalumab across various mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) tumours in the Drug Rediscovery Protocol (DRUP). This is a clinical study in which patients are treated with drugs outside their labeled indication, based on their tumour molecular profile.

14p vischultz 20-10-2023 3 1   Download

There is limited information of radical radiotherapy (RT) on lymphoepithelial carcinoma of salivary gland (LECSG) regarding to the rarity of the disease. We conducted this retrospective study that evaluated the feasibility and efficacy of radical RT with/without surgery in LECSG.

7p visharma 20-10-2023 3 2   Download

This study aims to evaluate the clinical efficacy and side effects of setting up a high-risk clinical target volume (CTV-hr) alongside simultaneous integrated boost intensity-modulated radiotherapy (IMRT-SIB) in patients diagnosed with stage IIB-IVA cervical cancer.

12p visharma 20-10-2023 2 2   Download

To evaluate the efficacy and safety of Neoretin Discrom Control Serum for the treatment of melasma. Methods: A clinical trial in 36 melasma patients treated with Neoretin Discrom Control Serum for 4 months. Patients were re-examined at weeks 4, 8, 12, 16; Facial pictures by digital camera were taken and were evaluated the improvement of melasma on the MASI scale, on dermoscopy, the change in Melanin index through the Mexameter, clinical side effects and patient satisfaction during and after treatment was noted.

7p viberbers 09-08-2023 5 2   Download

To evaluate the efficacy of the combination of fractional laser CO2 and narrowband ultraviolet B (NB-UVB) in the treatment of non-segmental vitiligo. Materials and methods: An prospective half-body comparative clinical study, was conducted on 31 lesions of vitiligo in 17 patients with non-segmental vitiligo.

8p viberbers 09-08-2023 5 2   Download