Evidence codes
-
Emerging evidence suggests the dysregulation of long non-coding RNAs (lncRNAs) involved in pancreatic cancer (PC). However, the function of LINC00930 in PC has not been elaborated. In this study, we found that LINC00930 was significantly down-regulated in PC cell lines and tissues, and associated with tumor size, lymphatic metastasis, TNM stage and poor prognosis.
14p vishanshan 27-06-2024 1 1 Download
-
Ebook Incident response: Computer forensics toolkit – Part 1 includes contents: Chapter 1: computer forensics and incident response essentials; chapter 2: addressing law enforcement considerations; chapter 3: forensic preparation and preliminary response; chapter 4: windows registry, recycle bin, and data storage; chapter 5: analyzing and detecting malicious code and intruders; chapter 6: retrieving and analyzing clues; chapter 7: procedures for collecting and preserving evidence.
178p longtimenosee05 31-03-2024 6 0 Download
-
The American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) clinical variant interpretation guidelines established criteria for different types of evidence. This includes the strong evidence codes PS3 and BS3 for “well-established” functional assays demonstrating a variant has abnormal or normal gene/protein function, respectively.
12p vibransone 28-03-2024 3 2 Download
-
Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel liver-specific lncRNA, FAM99A, and examined its clinical significance and biological functions in HCC.
19p vileonardodavinci 23-12-2023 7 3 Download
-
Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease is determined to be the mutations in the ITGB2 gene that codes for CD18, the beta chain of beta-2 integrins, leads to decreased expression or functioning of CD18. This deficiency leads to severe impairment of leukocyte adhesion to the vascular wall and leukocyte migration to sites of infection and inflammation.
7p vimulcahy 18-09-2023 5 3 Download
-
Ebook ACCA Paper F8 (Global): Audit and Assurance - Part 1 presents the following content: Chapter 1 The concept of audit and other assurance engagements, Chapter 2 Statutory audits, Chapter 3 The regulatory environment and corporate governance, Chapter 4 Professional ethics and ACCA's Code of Ethics and Conduct, Chapter 5 Internal audit, Chapter 6 Risk assessment, Chapter 7 Audit planning and documentation, Chapter 8 Introduction to audit evidence, Chapter 9 Internal control.
126p haojiubujain01 06-06-2023 5 1 Download
-
POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p vihagrid 30-01-2023 5 3 Download
-
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The aim of the study is to systematically characterize the lncRNA-associated competing endogenous RNA (ceRNA) network and identify key lncRNAs in the development of stage I lung adenocarcinoma (LUAD).
12p vikolindagrabar 27-07-2022 6 2 Download
-
Accumulating evidence suggests that LINC00511 acts as an oncogenic long non-coding RNA (lncRNA) in various cancers, including lung adenocarcinoma (LUAD). Hence, we attempted to elucidate the potential role of LINC00511 in LUAD.
16p vikolindagrabar 27-07-2022 3 2 Download
-
A growing body of evidence suggests that pyroptosis-related lncRNAs (PRncRNAs) are associated with the prognoses of tumor patients and their tumor immune microenvironments. However, the function of PRlncRNAs in lung squamous cell carcinoma (LUSC) remains unclear.
13p visusanwojcicki 28-06-2022 7 2 Download
-
While the analysis of Bornelöv et al. is informative, they provide evidence for the existence of only 3% of the reported avian missing genes set, and thus do not significantly challenge our main findings that specific groups of syntenic protein-coding genes are missing in birds.
3p vialfrednobel 29-01-2022 8 0 Download
-
The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert important functions.
29p viarchimedes 26-01-2022 11 0 Download
-
Bladder cancer (BLCA) typically has a poor prognosis due to high relapse and metastasis rates. A growing body of evidence indicates that N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) play crucial roles in the progression of BLCA and the treatment response of patients with BLCA.
15p vimahuateng 26-11-2021 14 2 Download
-
There is evidence that long non-coding RNA (lncRNA) is related to genetic stability. However, the complex biological functions of these lncRNAs are unclear. Multivariate Cox proportional hazard regression analysis was applied to conduct lncRNA prognosis model.
13p vimahuateng 26-11-2021 3 0 Download
-
Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in numerous tumors or diseases including glioma.
10p vimahuateng 26-11-2021 7 1 Download
-
New genes are constantly formed, sometimes from non-genic sequences, creating what is referred to as de novo genes. Since the total number of genes remains relatively steady, gene deaths likely balance out new births. In metazoan genomes, microRNAs (miRs) genes, small and non-coding, account for the bulk of functional de novo genes and are particularly suited to the investigation of gene death.
8p vibeauty 23-10-2021 5 1 Download
-
With only 2 % of the human genome consisting of protein coding genes, functionality across the rest of the genome has been the subject of much debate. This has gained further impetus in recent years due to a rapidly growing catalogue of genomic elements, based primarily on biochemical signatures (e.g. the ENCODE project). While the assessment of functionality is a complex task, the presence of selection acting on a genomic region is a strong indicator of importance. In this study, we apply population genetic methods to investigate signals overlaying several classes of regulatory elements.
14p vibeauty 23-10-2021 18 2 Download
-
MicroRNAs (miRNAs) are small non-coding RNAs that bind messenger RNAs and promote their degradation or repress their translation. There is increasing evidence of miRNAs playing an important role in alcohol related disorders. However, the role of miRNAs as mediators of the genetic effect on alcohol phenotypes is not fully understood.
12p vitzuyu2711 29-09-2021 10 1 Download
-
The severity and frequency of drought has increased around the globe, creating challenges in ensuring food security for a growing world population. As a consequence, improving water use efficiency by crops has become an important objective for crop improvement.
16p vijeeni2711 24-07-2021 11 0 Download
-
The gonad is the major factor affecting animal reproduction. The regulatory mechanism of the expression of protein-coding genes involved in reproduction still remains to be elucidated. Increasing evidence has shown that ncRNAs play key regulatory roles in gene expression in many life processes.
11p vijeeni2711 24-07-2021 15 0 Download